Results 11 to 20 of about 6,513 (167)

Genome-wide identification of the jumonji C domain- containing histone demethylase gene family in wheat and their expression analysis under drought stress

Frontiers in Plant Science, 2022
Methylation and demethylation of histone play a crucial role in regulating chromatin formation and gene expression. The jumonji C (JmjC) domain-containing proteins are demethylases that are involved in regulating epigenetic modification in plants. In our
Xinhua Wang, Xinhua Wang, Cuili Pan, Jiaohui Long, Shuangyu Bai, Mingming Yao, Jiajing Chen, Gang Sun, Yalei Fan, Zhangjun Wang, Fenglou Liu, Caixia Liu, Qingfeng Li   +12 more
doaj   +3 more sources

Lysine demethylase 4A: from chromatin to centrosomes. [PDF]

FEBS J
The lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome.
Sharma A, Kearney RM, Morrison CG.
europepmc   +2 more sources

Profiling Inhibitor Scaffolds for the Cancer Target Jumonji-C Domain-Containing Protein 6. [PDF]

ChemMedChem
High‐throughput mass spectrometry assays identify scaffolds for the development of inhibitors of the anticancer target Jumonji‐C domain‐containing protein 6 (JMJD6). Molecular docking studies suggest strategies for structure‐guided inhibitor optimization.
Corner TP, Salah E, Tumber A, Holt-Martyn JP, Brewitz L, Schofield CJ.   +5 more
europepmc   +2 more sources

Arabidopsis TRB Proteins Form Two Closely Related Complexes to Mediate H3K4me3 Demethylation and Transcriptional Repression. [PDF]

Adv Sci (Weinh)
This study reveals that Arabidopsis telomere repeat binding proteins (TRBs) form two closely related complexes. These complexes mediate H3K4me3 demethylation and transcriptional repression through a positive feedback loop and cooperate with PEAT and PRC2 complexes to regulate multiple histone modifications and gene expression across the genome ...
Wang Q, Yuan DY, Lu YJ, Wang X, Zheng H, Li L, Chen S, He XJ.   +7 more
europepmc   +2 more sources

The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
The small GTPase RHOJ is a key regulator of breast cancer metastasis by promoting cell migration and invasion. The prometastatic stimulus TGF-β activates RHOJ transcription via megakaryocytic leukemia 1 (MKL1). The underlying epigenetic mechanism is not clear.
Ziyu Zhang, Baoyu Chen, Yuwen Zhu, Tianyi Zhang, Xiaoling Zhang, Xiaoling Zhang, Yibiao Yuan, Yong Xu, Yong Xu   +8 more
openaire   +3 more sources

Corrigendum: The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells [PDF]

Frontiers in Cell and Developmental Biology, 2021
[This corrects the article DOI: 10.3389/fcell.2021.664375.].
Ziyu Zhang, Baoyu Chen, Yuwen Zhu, Tianyi Zhang, Xiaoling Zhang, Xiaoling Zhang, Yibiao Yuan, Yong Xu, Yong Xu   +8 more
openaire   +3 more sources

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α [PDF]

Biochemical Journal, 2008
The transcription factor HIF (hypoxia-inducible factor) mediates a highly pleiotrophic response to hypoxia. Many recent studies have focused on defining the extent of this transcriptional response. In the present study we have analysed regulation by hypoxia among transcripts encoding human Fe(II)- and 2-oxoglutarate-dependent oxygenases.
Pollard, Patrick J, Loenarz, Christoph, Mole, David R, McDonough, Michael A, Gleadle, Jonathan, Schofield, Christopher J, Ratcliffe, Peter J   +6 more
openaire   +4 more sources

Nitric Oxide Modifies Global Histone Methylation by Inhibiting Jumonji C Domain-containing Demethylases [PDF]

Journal of Biological Chemistry, 2013
Methylation of lysine residues on histone tails is an important epigenetic modification that is dynamically regulated through the combined effects of methyltransferases and demethylases. The Jumonji C domain Fe(II) α-ketoglutarate family of proteins performs the majority of histone demethylation.
Jason R, Hickok, Divya, Vasudevan, William E, Antholine, Douglas D, Thomas   +3 more
openaire   +2 more sources

Inhibitors of Jumonji C domain-containing histone lysine demethylases overcome cisplatin and paclitaxel resistance in non-small cell lung cancer through APC/Cdh1-dependent degradation of CtIP and PAF15 [PDF]

Cancer Biology & Therapy, 2022
The Jumonji C domain-containing family of histone lysine demethylases (Jumonji KDMs) have emerged as promising cancer therapy targets. These enzymes remove methyl groups from various histone lysines and, in turn, regulate processes including chromatin compaction, gene transcription, and DNA repair.
Duan, Lei, Perez, Ricardo E., Calhoun, Sarah, Maki, Carl G.   +3 more
openaire   +2 more sources

The histone demethylase Jumonji domain-containing protein 3 (JMJD3) regulates fibroblast activation in systemic sclerosis [PDF]

Annals of the Rheumatic Diseases, 2018
Systemic sclerosis (SSc) fibroblasts remain activated even in the absence of exogenous stimuli. Epigenetic alterations are thought to play a role for this endogenous activation. Trimethylation of histone H3 on lysine 27 (H3K27me3) is regulated by Jumonji domain-containing protein 3 (JMJD3) and ubiquitously transcribed tetratricopeptide repeat on ...
Bergmann, Christina, Brandt, Amelie, Merlevede, Benita, Hallenberger, Ludwig, Dees, Clara, Wohlfahrt, Thomas, Pötter, Sebastian, Zhang, Yun, Chen, Chih-Wei, Mallano, Tatiana, Liang, Ruifang, Kagwiria, Rosebeth, Kreuter, Alexander, Pantelaki, Ioanna, Bozec, Aline, Abraham, David, Rieker, Ralf, Ramming, Andreas, Distler, Oliver, Schett, Georg, Distler, Jörg H W   +20 more
openaire   +4 more sources