Results 11 to 20 of about 60 (59)

Stage-dependent and locus-specific role of histone demethylase Jumonji D3 (JMJD3) in the embryonic stages of lung development. [PDF]

PLoS Genetics, 2014
Histone demethylases have emerged as important players in developmental processes. Jumonji domain containing-3 (Jmjd3) has been identified as a key histone demethylase that plays a critical role in the regulation of gene expression; however, the in vivo ...
Qingtian Li, Helen Y Wang, Iouri Chepelev, Qingyuan Zhu, Gang Wei, Keji Zhao, Rong-Fu Wang   +6 more
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JMJD5 attenuates oxygen–glucose deprivation and reperfusion‐induced injury in cardiomyocytes through regulation of HIF‐1α‐BNIP3

Kaohsiung Journal of Medical Sciences, 2022
Proteins in Jumonji family function as histone demethylases and participate in cardiac development. Jumonji domain containing 5 (JMJD5) is responsible for the embryonic development through removing methyl moieties from H3K36me2 histone, and has pro ...
Ya‐Nan Zhang, Ya‐Xiang Pang, Da‐Wei Liu, Hai‐Juan Hu, Rui‐Qin Xie, Wei Cui   +5 more
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Hepatic lipid accumulation alters global histone h3 lysine 9 and 4 trimethylation in the peroxisome proliferator-activated receptor alpha network. [PDF]

PLoS ONE, 2012
Recent data suggest that the etiology of several metabolic diseases is closely associated with transcriptome alteration by aberrant histone methylation.
Hee-Jin Jun, Jinyoung Kim, Minh-Hien Hoang, Sung-Joon Lee   +3 more
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The Arabidopsis H3K27me3 demethylase JUMONJI 13 is a temperature and photoperiod dependent flowering repressor

Nature Communications, 2019
Jumonji domain-containing histone demethylases regulate flowering in plants. Here Zheng et al. show that Arabidopsis JMJ13 is an H3K27me3 demethylase that recognizes H3K27me3 via hydrogen bonding and hydrophobic interactions and affects both photoperiod ...
Shuzhi Zheng, Hongmiao Hu, Huimin Ren, Zhenlin Yang, Qi Qiu, Weiwei Qi, Xinye Liu, Xiaomei Chen, Xiekui Cui, Sisi Li, Bing Zhou, Daye Sun, Xiaofeng Cao, Jiamu Du   +13 more
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Genome-wide analysis of soybean JmjC domain-containing proteins suggests evolutionary conservation following whole-genome duplication

Frontiers in Plant Science, 2016
Histone modifications, such as methylation and demethylation, play an important role in regulating chromatin structure and gene expression. The JmjC domain-containing proteins, an important family of histone lysine demethylases (KDMs), play a key role in
Yapeng Han, Xiangyong Li, Lin Cheng, Yanchun Liu, Hui Wang, Danxia Ke, Hongyu Yuan, Liangsheng Zhang, Lei Wang   +8 more
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Reprogramming the Epigenome With Vitamin C

Frontiers in Cell and Developmental Biology, 2019
The erasure of epigenetic modifications across the genome of somatic cells is an essential requirement during their reprogramming into induced pluripotent stem cells (iPSCs).
Taylor Lee Chong, Emily L. Ahearn, Luisa Cimmino, Luisa Cimmino   +3 more
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Therapeutic Potentials of Inhibition of Jumonji C Domaincontaining Demethylases in Acute Myeloid Leukemia

Turkish Journal of Hematology, 2020
Objective: Acute myeloid leukemia (AML) is a complex disease affected by both genetic and epigenetic factors. Histone methylation and demethylation are types of epigenetic modification in chromatin remodeling and gene expression.
Duygu Koca, Nurcan Haştar, Selin Engür, Yağmur Kiraz, Gizem Tuğçe Ulu, Demet Çekdemir, Yusuf Baran   +6 more
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HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury

Cellular & Molecular Biology Letters, 2021
Background Endothelial cell (EC) injury accelerates the progression of diabetic macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible factor-1 alpha (HIF-1α) is an important hypoxia regulatory protein.
Min Zhao, Shaoting Wang, Anna Zuo, Jiaxing Zhang, Weiheng Wen, Weiqiang Jiang, Hong Chen, Donghui Liang, Jia Sun, Ming Wang   +9 more
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Prohexadione, a plant growth regulator, inhibits histone lysine demethylases and modulates epigenetics

Toxicology Reports, 2014
Background: Epigenetic modifications, particularly DNA methylation and posttranslational histone modifications regulate heritable changes in transcription without changes in the DNA sequence.
Divya Teja Vavilala, Sujatha Reddy, Sachchidanand, Swami Prakash, V.K. Chaithanya Ponnaluri, Arvind Kumar, Mridul Mukherji   +6 more
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A convenient research strategy for functional verification of epigenetic regulators during spermatogenesis

Asian Journal of Andrology
Spermatogenesis is a fundamental process that requires a tightly controlled epigenetic event in spermatogonial stem cells (SSCs). The mechanisms underlying the transition from SSCs to sperm are largely unknown.
Shan Li, Ying Yuan, Ke-Yu Zhang, Yi-Dan Guo, Lu-Tong Wang, Xiao-Yuan Zhang, Shu Zhang, Qi Yan, Rong Zhang, Jie Chen, Feng-Tang Yang, Jing-Rui Li   +11 more
doaj   +1 more source