The roles of XJ13 and XJ44-specific mutations within the Candid #1 GPC in Junin virus attenuation [PDF]
Frontiers in Immunology, 2023 Junin virus (JUNV) is a member of the Arenaviridae family of viruses and is the pathogen responsible for causing Argentine hemorrhagic fever, a potentially lethal disease endemic to Argentina.
John Tyler Manning +8 more
doaj +2 more sources
Junin Virus Activates p38 MAPK and HSP27 Upon Entry [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Junín virus (JUNV), a New World arenavirus, is a rodent-borne virus and the causative agent of Argentine hemorrhagic fever. Humans become infected through exposure to rodent host secreta and excreta and the resulting infection can lead to an acute ...
Collin J. Fitzpatrick +11 more
doaj +2 more sources
Type I interferon underlies severe disease associated with Junín virus infection in mice [PDF]
eLife, 2020 Junín virus (JUNV) is one of five New World mammarenaviruses (NWMs) that causes fatal hemorrhagic disease in humans and is the etiological agent of Argentine hemorrhagic fever (AHF).
Brady T Hickerson +5 more
doaj +2 more sources
Nuclease Activity of the Junín Virus Nucleoprotein C-Terminal Domain [PDF]
Viruses, 2023 The mammarenavirus Junín (JUNV) is the causative agent of Argentine hemorrhagic fever, a severe disease of public health concern. The most abundant viral protein is the nucleoprotein (NP), a multifunctional, two-domain protein with the primary role as ...
Alicia Armella Sierra +6 more
doaj +2 more sources
Potential and action mechanism of favipiravir as an antiviral against Junin virus. [PDF]
PLoS Pathogens, 2022 Favipiravir is a nucleoside analogue that inhibits the replication and transcription of a broad spectrum of RNA viruses, including pathogenic arenaviruses.
Vahid Rajabali Zadeh +4 more
doaj +2 more sources
Junín Virus Pathogenesis and Virus Replication [PDF]
Viruses, 2012 Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina.
Olga Kolokoltsova +6 more
doaj +2 more sources
Single dose rVSVΔG-JUNVGP vaccine protects guinea pigs against lethal Junin virus challenge [PDF]
npj Vaccines, 2021 Junin virus (JUNV) is a pathogen of biodefense importance due to its potential for aerosol transmission and mortality rates reaching 30%. Currently, there are no JUNV vaccines licensed by the United States Food and Drug Administration (FDA) for at-risk ...
Teresa E. Sorvillo +6 more
doaj +2 more sources
Junin Virus Triggers Macrophage Activation and Modulates Polarization According to Viral Strain Pathogenicity [PDF]
Frontiers in Immunology, 2019 The New World arenavirus Junin (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF). Previous studies of human macrophage infection by the Old-World arenaviruses Mopeia and Lassa showed that while the non-pathogenic Mopeia virus ...
María F. Ferrer +12 more
doaj +2 more sources
Junín virus induces autophagy in human A549 cells. [PDF]
PLoS ONE, 2019 Autophagy, a highly regulated degradative process that promotes cellular homeostasis, is increasingly recognised as a fundamental component of the cellular response against viral infection.
Maria Laura A Perez Vidakovics +4 more
doaj +2 more sources
Monoclonal antibody therapy for Junin virus infection. [PDF]
Proc Natl Acad Sci U S A, 2016 Significance There are no Food and Drug Administration approved drugs available for preventing or treating Argentine hemorrhagic fever (AHF), and the current treatment option is limited to administration of immune plasma. With the expanding clinical use of monoclonal antibodies (mAbs) for acute and chronic conditions, it has become ...
Zeitlin L +22 more
europepmc +4 more sources