Results 1 to 10 of about 48,573 (291)

Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor

Cell Reports, 2016
Synaptic communication between neurons requires the precise localization of neurotransmitter receptors to the correct synapse type. Kainate-type glutamate receptors restrict synaptic localization that is determined by the afferent presynaptic connection.
Christoph Straub, Yoav Noam, Toshihiro Nomura, Miwako Yamasaki, Dan Yan, Herman B. Fernandes, Ping Zhang, James R. Howe, Masahiko Watanabe, Anis Contractor, Susumu Tomita   +10 more
doaj   +2 more sources

Oligodendrocyte precursor cell AMPA receptors differ with age and brain region while kainate receptors remain stable [PDF]

iScience
Summary: Oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life. Many cues modulate OPC proliferation and differentiation, including neuronal activity, which OPCs sense through voltage-gated
Yasmine Kamen, Kimberley Anne Evans, Yan Ting Ng, Sabine Dietmann, Ragnhildur Thóra Káradóttir   +4 more
doaj   +2 more sources

AMPA Receptors in NG2 Glia Differently Affect Signal Transduction in the Hippocampus and Cerebellum. [PDF]

Glia
Stronger expression of Ca2+ permeable AMPA receptors in cerebellar versus hippocampal NG2 glia. Different expression patterns of glial AMPA receptors and auxiliary subunits in both regions. Higher efficacy of neuron‐NG2 glia synapses in the cerebellum.
Tascio D, Gebril N, Jabs R, Henneberger C, Steinhäuser C, Seifert G.   +5 more
europepmc   +2 more sources

GluK2 kainate receptor subunit-selective, potentiating RNA aptamer [PDF]

Scientific Reports
Kainate receptors are a subtype of ionotropic glutamate receptors. Potent and selective modulatory agents of kainate receptors are potential drug candidates for treatment of various neurological diseases involving receptor dysregulation.
Samantha R. Ingenito, Noah Saunders, Kyle J. Lininger, Li Niu   +3 more
doaj   +2 more sources

Ethanolic and aqueous extracts of Lantana camara show antiepileptic and anxiolytic effects by inhibiting the ferroptosis pathway in kainate-treated mice [PDF]

IBRO Neuroscience Reports
In Cameroon, epilepsy is one of the most common neurological diseases. Available anti-epileptic medication, on the other hand, have been associated with pharmacological toxicity and emotional impairment. The identification of a more efficient replacement
Mabou Symphorien Talom, Kandeda Antoine Kavaye, Bilanda Danielle Claude, Nkengne Steve Melton, Soffo Gildas Moffo, Edzoa Xavier Francois   +5 more
doaj   +2 more sources

Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey. [PDF]

Hippocampus
ABSTRACT I describe my progress in understanding synaptic plasticity in the hippocampus. Over the decades my lab has focused on the roles of glutamate receptors (AMPARs, NMDARs, mGluRs and KARs) and associated signaling molecules in LTP and LTD. Most of our studies have been conducted in area CA1 (Schaffer collateral—commissural pathway) with some ...
Collingridge GL.
europepmc   +2 more sources

Mitochondrial superoxide production and MnSOD activity following exposure to an agonist and antagonists of ionotropic receptors in rat brain [PDF]

Archives of Biological Sciences, 2005
The involvement of NMDA and AMPA/kainate receptors in the induction of superoxide production in the rat brain was examined after intrahippocampal injection of kainate, a non-NMDA receptor agonist; kainate plus CNQX, a selective AMPA/kainate receptor ...
Radenović Lidija Lj., Selaković Vesna
doaj   +1 more source

Structural Arrangement Produced by Concanavalin A Binding to Homomeric GluK2 Receptors

Membranes, 2021
Kainate receptors are members of the ionotropic glutamate receptor family. They form cation-specific transmembrane channels upon binding glutamate that desensitize in the continued presence of agonists.
Cuauhtemoc U. Gonzalez, Elisa Carrillo, Vladimir Berka, Vasanthi Jayaraman   +3 more
doaj   +1 more source

Effect of glutamate antagonists on nitric oxide production in rat brain following intrahippocampal injection [PDF]

Archives of Biological Sciences, 2007
Stimulation of glutamate receptors induces neuronal nitric oxide (NO) release, which in turn modulates glutamate transmission. The involvement of ionotropic glutamate NMDA and AMPA/kainate receptors in induction of NO production in the rat brain was ...
Radenović Lidija, Selaković Vesna, Janać Branka, Todorović Dajana   +3 more
doaj   +1 more source

Resilient Hippocampal Gamma Rhythmogenesis and Parvalbumin-Expressing Interneuron Function Before and After Plaque Burden in 5xFAD Alzheimer’s Disease Model

Frontiers in Synaptic Neuroscience, 2022
Recent studies have implicated impaired Parvalbumin Fast-Spiking Interneuron (PVIN) function as a precipitating factor underlying abnormalities in network synchrony, oscillatory rhythms, and cognition associated with Alzheimer’s disease (AD).
Connie A. Mackenzie-Gray Scott, Connie A. Mackenzie-Gray Scott, Kenneth A. Pelkey, Adam P. Caccavano, Daniel Abebe, Mandy Lai, Khayla N. Black, Nicolette D. Brown, Andrew J. Trevelyan, Chris J. McBain   +9 more
doaj   +1 more source