Results 91 to 100 of about 25,211,180 (156)

Kinin B1 and B2 receptor deficiency protects against obesity induced by a high-fat diet and improves glucose tolerance in mice

Diabetes, Metabolic Syndrome and Obesity, 2015
Rafael L Morais,1 Elton D Silva,1 Vicência M Sales,1 Rafael Filippelli-Silva,1 Marcelo A Mori,1 Michael Bader,2 João B Pesquero1 1Department of Biophysics, Universidade Federal de São Paulo, São Paulo, Brazil; 2Max-Delbrü ...
Morais RL, Silva ED, Sales VM, Filippelli-Silva R, Mori MA, Bader M, Pesquero JB   +6 more
doaj  

Molecular mechanisms for subtype selectivity of kinin receptors’ antagonists

Nature Communications
The kinin receptors B1R and B2R act as key regulators within the kallikrein–kinin system, mediating vasodilation, inflammation, and pain. Antagonists targeting these receptors have shown therapeutic potential in the treatment of angioedema, pancreatitis,
Meng Xia, Aleksey Raskovalov, My V. T. Nguyen, Shiliu Mei, Donggyun Kim, Jayden Salve, Vsevolod Katritch, Vadim Cherezov, Haitao Zhang   +8 more
doaj   +1 more source

Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitors

Brazilian Journal of Medical and Biological Research, 2003
Human plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrinolysis. The proteolytic enzymes involved in these processes are usually controlled by specific inhibitors and may be ...
Gozzo A.J., Nunes V.A., Nader H.B., Dietrich C.P., Carmona A.K., Sampaio M.U., Sampaio C.A.M., Araújo M.S.   +7 more
doaj  

Kallikrein-kinin system as a potential target for the treatment of intervertebral disc degeneration. [PDF]

Eur J Med Res
Lu T, Zhu W, Yang F, Zhu K, Ren J, Zhu H, Ye B, Sun F, Zhang W, Qiu X.   +9 more
europepmc   +1 more source

Erratum: A novel assay of excess plasma kallikrein-kinin system activation in hereditary angioedema. [PDF]

Front Allergy
Frontiers Production Office.
europepmc   +1 more source

Corrigendum: A novel assay of excess plasma kallikrein-kinin system activation in hereditary angioedema. [PDF]

Front Allergy
Sexton D, Faucette R, Rivera-Hernandez M, Kenniston JA, Papaioannou N, Cosic J, Kopacz K, Salmon G, Beauchemin C, Juethner S, Yeung D.   +10 more
europepmc   +1 more source

Kallikrein-kinin system as the dominant mechanism to counteract hyperactive renin-angiotensin system.

Canadian Journal of Physiology and Pharmacology, 2017
D. Regoli, F. Gobeil
semanticscholar   +1 more source

Novel Insights into the Kallikrein-Kinin System in Fulminant Myocarditis: Physiological Basis and Potential Therapeutic Advances. [PDF]

J Inflamm Res
Ji M, Ran X, Zuo H, Zhang Q.
europepmc   +1 more source

Differences in the expression of the renin angiotensin system and the kallikrein-kinin system during the course of myocardial infarction in male and female Wistar rats. [PDF]

J Renin Angiotensin Aldosterone Syst, 2020
Flores-Monroy J, Lezama-Martínez D, Fonseca-Coronado S, Martínez-Aguilar L.   +3 more
europepmc   +1 more source

A mechanistic model of in vitro plasma activation to evaluate therapeutic kallikrein-kinin system inhibitors. [PDF]

PLoS Comput Biol
Rezvani-Sharif A, Lioe H, Dower SK, Pelzing M, Panousis C, Harvie DJE, Muir IL.   +6 more
europepmc   +1 more source