Results 71 to 80 of about 5,170 (128)

Pharmacological suppression of the kallikrein kinin system with KVD900: An orally available plasma kallikrein inhibitor for the on-demand treatment of hereditary angioedema. [PDF]

Clin Exp Allergy, 2022
Duckworth EJ, Murugesan N, Li L, Rushbrooke LJ, Lee DK, De Donatis GM, Maetzel A, Yea CM, Hampton SL, Feener EP.   +9 more
europepmc   +1 more source

Molecular mechanisms for subtype selectivity of kinin receptors’ antagonists

Nature Communications
The kinin receptors B1R and B2R act as key regulators within the kallikrein–kinin system, mediating vasodilation, inflammation, and pain. Antagonists targeting these receptors have shown therapeutic potential in the treatment of angioedema, pancreatitis,
Meng Xia, Aleksey Raskovalov, My V. T. Nguyen, Shiliu Mei, Donggyun Kim, Jayden Salve, Vsevolod Katritch, Vadim Cherezov, Haitao Zhang   +8 more
doaj   +1 more source

Targeted LC-MS/MS platform for the comprehensive determination of peptides in the kallikrein-kinin system. [PDF]

Anal Bioanal Chem, 2021
Gangnus T, Burckhardt BB.
europepmc   +1 more source

The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System. [PDF]

Front Immunol, 2021
Lipcsey M, Persson B, Eriksson O, Blom AM, Fromell K, Hultström M, Huber-Lang M, Ekdahl KN, Frithiof R, Nilsson B.   +9 more
europepmc   +1 more source

Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitors

Brazilian Journal of Medical and Biological Research, 2003
Human plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrinolysis. The proteolytic enzymes involved in these processes are usually controlled by specific inhibitors and may be ...
Gozzo A.J., Nunes V.A., Nader H.B., Dietrich C.P., Carmona A.K., Sampaio M.U., Sampaio C.A.M., Araújo M.S.   +7 more
doaj  

The evolution of factor XI and the kallikrein-kinin system. [PDF]

Blood Adv, 2020
Ponczek MB, Shamanaev A, LaPlace A, Dickeson SK, Srivastava P, Sun MF, Gruber A, Kastrup C, Emsley J, Gailani D.   +9 more
europepmc   +1 more source

The Kallikrein-Kinin System: Proteolytic Orchestrators of Tissue Barrier Disruption in Inflammation and Cancer. [PDF]

Int J Mol Sci
Cárdenas-Oyarzo A, Figueroa CD, Huilcamán R, Turones L, Martínez-Huenchullán S, Ehrenfeld P.   +5 more
europepmc   +1 more source

A systematic review of the measurement of the renin-angiotensin and kallikrein-kinin system peptides in normotension and hypertension. [PDF]

J Hum Hypertens
Gyedu EJ, Jenkins S, Lane D, Akram A, Salim F, Ng LL, Jones DJL, Bernieh D, Gupta P.   +8 more
europepmc   +1 more source

Treatment of COVID-19 With Conestat Alfa, a Regulator of the Complement, Contact Activation and Kallikrein-Kinin System. [PDF]

Front Immunol, 2020
Urwyler P, Moser S, Charitos P, Heijnen IAFM, Rudin M, Sommer G, Giannetti BM, Bassetti S, Sendi P, Trendelenburg M, Osthoff M.   +10 more
europepmc   +1 more source

The kallikrein-kinin system modulates CD4⁺ T cell function and contributes to T cell migration into the brain after stroke. [PDF]

J Neuroinflammation
Gausmann N, Haupeltshofer S, Szepanowski RD, Luppus S, Dzyubenko E, Bahr J, Mencl S, Gronewold J, Hermann DM, Forsting M, Deuschl C, Buer J, Westendorf AM, Kleinschnitz C, Casas AI, Hansen W.   +15 more
europepmc   +1 more source