Results 81 to 90 of about 25,211,180 (156)

Serum Proteomics of Multiple Menstrual Symptoms in Female Athletes: A Pilot Study

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
The graphical abstract illustrates the proteomic workflow. Serum samples and menstrual symptom questionnaire scores from female volunteers were collected at each sampling point. Two‐dimensional gel electrophoresis (2DE) images were generated from the serum, and statistical analyses that combined the questionnaire scores with the 2DE images were ...
Kai Fushimi, Tasuku Kondo, Nodoka Ikegami, Mizuki Yamada, Sing Ying Wong, Mikako Sakamaki‐Sunaga, Nobuhiro Hayashi   +6 more
wiley   +1 more source

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, Volume 12, Issue 1, Page 96-122, Spring 2026.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Proteomic Analysis of Cerebrospinal Fluid from Severe COVID‐19 Patients Reveals Prognostic Biomarkers Associated with Disease Outcome

PROTEOMICS – Clinical Applications, Volume 20, Issue 2, March 2026.
ABSTRACT Purpose Coronavirus disease 2019 (COVID‐19) has highlighted significant neurological complications in severe cases. Cerebrospinal fluid (CSF) proteomics could reveal biomarkers related to clinical outcome among critically ill patients. Experimental Design We performed high‐resolution proteomic analyses of CSF samples from 29 intensive care ...
Harry Alexopoulos, Martina Samiotaki, Eirini Gkogkou, Sofia Mavromati, Kleopatra Bitzogli, Georgios Panagiotou, Athanasios Tzioufas, Eleni Magira, Αnastasia Kotanidou, Ioannis Trougakos   +9 more
wiley   +1 more source

EL ROL DEL SISTEMA CALICREÍNA-CININAS EN UN MODELO EXPERIMENTAL DE DIABETES. ESTUDIO DE LA PATOLOGÍA AÓRTICA

Revistas Argentina de Medicina, 2017
La hiperglucemia progresiva en la diabetes mellitus está asociada con daño significativo y disfunción del sistema endotelial vascular, así como con alteraciones micro y macrovasculares, permeabilidad vascular, ateroesclerosis y modificaciones del estrés
Orlando Catanzaro, Irene Di Martino, Jorgelina Aira Capponi   +2 more
doaj   +2 more sources

Imbalance of kallikrein-kinin system in chronic pancreatitis combined with obesity and results of its comprehensive correction

Gastroenterologìa, 2017
Background. Chronic pancreatitis is one of the most common diseases in general therapeutic practice. Significant role in the onset and progression of chronic pancreatitis is played by the activation of the kallikrein-kinin system (KKS), which is involved
L.S. Babinets, K.Yu. Kytsai
doaj   +1 more source

Population Pharmacokinetic/Pharmacodynamic Modeling of Donidalorsen, an Antisense Oligonucleotide in Development for Prophylaxis of Hereditary Angioedema

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Hereditary angioedema (HAE) is a rare disorder linked to kallikrein‐kinin system dysregulation, which leads to uncontrolled activation of plasma prekallikrein. Donidalorsen is an antisense oligonucleotide designed to selectively degrade prekallikrein messenger RNA and thereby reduce prekallikrein production.
John K. Diep, Miao Liu, Pratap Singh, Steve Dorow, Danny M. Cohn, Laura Bordone, Kenneth B. Newman, Xiang Gao   +7 more
wiley   +1 more source

Chronic Overexpression of Bradykinin in Kidney Causes Polyuria and Cardiac Hypertrophy

Frontiers in Medicine, 2018
Acute intra-renal infusion of bradykinin increases diuresis and natriuresis via inhibition of vasopressin activity. However, the consequences of chronically increased bradykinin in the kidneys have not yet been studied.
Carlos C. Barros, Ines Schadock, Ines Schadock, Gabin Sihn, Franziska Rother, Ping Xu, Elena Popova, Irina Lapidus, Ralph Plehm, Arnd Heuser, Mihail Todiras, Sebastian Bachmann, Natalia Alenina, Natalia Alenina, Ronaldo C. Araujo, Joao B. Pesquero, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Michael Bader   +21 more
doaj   +1 more source

Antagonism of Kinin Receptors B1 and B2 Attenuates Folic Acid‐Induced Tubulointerstitial Fibrosis in Mice

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 2, February 2026.
ABSTRACT Chronic kidney disease (CKD) remains a significant global health burden despite recent advances in pharmacotherapy, including sodium‐glucose cotransporter 2 (SGLT2) inhibitors and mineralocorticoid receptor antagonists. Renal fibrosis, a central pathological hallmark of CKD progression, is mediated by persistent inflammation and macrophage ...
Gabriel Rufino Estrela, Alexandre Budu, Juliene Silva, Raisa Brito, Frederick Wasinski, Jonatan Barrera‐Chimal, Ronaldo Carvalho Araujo   +6 more
wiley   +1 more source

Activity of kallikrein-kinin system in children in norm and at some pathological states

Бюллетень сибирской медицины, 2009
Proteolytic systems of tissue and blood plasma take part in the processes of adaptation and protection of an organism, as well as in development of pathological reactions.
Ye. I. Kondratiyeva, T. Ye. Tropova, G. A. Sukhanova, A. A. Terentiyeva, T. S. Krivonogova, V. V. Gorev, N. P. Stepanenko, Ye. Yu. Tyuteva   +7 more
doaj   +1 more source

Renin-angiotensin and kallikrein-kinin systems in diabetic retinopathy [PDF]

Scripta Medica, 2019
This brief review describes how two complex systems, the renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS), affect the retina.
Igić Rajko
doaj