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The Kallikrein/Kinin System in Ocular Function
Journal of Ocular Pharmacology and Therapeutics, 2011The kallikrein/kinin system uses two distinct serine proteases, plasma kallikrein and tissue kallikrein, to yield bradykinin and Lys-bradykinin (kallidin) from specific substrate kininogens. The kallikrein/kinin system is known to have a role in contact-activated coagulation mechanisms and in inflammatory responses, and recently has been shown to ...
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The renin–angiotensin and the kallikrein–kinin systems
The International Journal of Biochemistry & Cell Biology, 2003The renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS) each encompasses a large number of molecules, with several participating in both systems. The RAS generates a family of bioactive angiotensin peptides with varying biological activities.
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Pulmonary Anaphylaxis and the Kallikrein-Kinin System
1979The kallikrein-kinin system has been thought to participate in the pathogenesis of anaphylaxis. Kallikrein, released from lungs, has been postulated to contribute to cardiovascular collapse. Further to test the hypothesis, we examined for the occurrence of a kallikrein-like enzyme in guinea pig lungs and examined for release of such an enzyme by ...
N B, Oza +4 more
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The Kallikrein-Kinin System in Essential Hypertension
Clinical and Experimental Hypertension, 1980The kallikrein-kinin system is a potent vasodilator system with components in plasma and in exocrine glands, including the kidney. Kinins function as local hormones and exert effects on blood vessels and on water and electrolyte balance. The most frequently studied component of this system, urinary kallikrein, has been shown to respond to changes in ...
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Regulation of Angiogenesis by the Kallikrein-Kinin System
Current Pharmaceutical Design, 2006High molecular weight kininogen (HK) is a plasma protein that is cleaved by plasma kallikrein in the clinical settings of sepsis and chronic inflammatory diseases such as rheumatoid arthritis and Crohn's disease. This proteolytic event results in a nonapeptide, bradykinin (BK), and a kinin-free derivative of HK, namely HKa.
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The Kallikrein-Kinin System and Hypertension
2007Tissue (glandular or renal) kallikrein (E.C. 3.4.21.35) belongs to a subgroup of serine proteinases and processes low molecular weight kininogen substrate to release vasoactive kinin peptides (1). The well-recognized function of tissue kallikrein is mediated by lysyl-bradykinin (Lys-BK or kallidin) and bradykinin (BK), which consist of 10 and 9 amino ...
Julie Chao, Lee Chao
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Antisense Inhibition of the Brain Kallikrein-Kinin System
Hypertension, 1996We used antisense oligodeoxynucleotide (ODN) strategy, based on interference of information flow from gene to protein, to determine the role of kininogen and bradykinin B2receptor genes in the pathogenesis of genetic hypertension in rats. Mean blood pressure of 9-week-old spontaneously hypertensive rats (SHR) increased 4 hours after acute ...
MADEDDU P +4 more
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Kallikrein-Kinin System in Infectious Diseases
1989Infectious disease including those caused by viruses, rickettsia, fungi, parasites and bacteria are known to be associated with hemostatic disorders1 including disseminated intravascular coagulation (DIC). This paper will concentrate on the pathogenesis of the coagulation abnormalities in particular changes in surface mediated events of plasma ...
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[Prostaglandin and kallikrein-kinin systems].
Nihon rinsho. Japanese journal of clinical medicine, 1997We reviewed the recent advances in the molecular characterization of prostanoid and bradykinin receptors. Prostanoids and bradykinin exert versatile actions in diverse tissues and cells through specific cell surface receptors. Molecular biological studies revealed the primary structure of eight types and subtypes of prostanoid receptors from various ...
H, Yoshida, N, Ura, K, Shimamoto
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