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Components of the Kallikrein-Kinin System in Urine
1979The excretion of kallikrein in urine varies, but the pathophysiologic implications are not clear. To help clarify the role of the urinary kallikrein-kinin system, we have begun to define components of the system as they occur in urine. To minimize artifacts which may arise through extensive purification procedures, we studied urinary protein ...
J W, Ryan +3 more
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The Kallikrein-Kinin System in Essential Hypertension
Clinical and Experimental Hypertension, 1980The kallikrein-kinin system is a potent vasodilator system with components in plasma and in exocrine glands, including the kidney. Kinins function as local hormones and exert effects on blood vessels and on water and electrolyte balance. The most frequently studied component of this system, urinary kallikrein, has been shown to respond to changes in ...
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Regulation of Angiogenesis by the Kallikrein-Kinin System
Current Pharmaceutical Design, 2006High molecular weight kininogen (HK) is a plasma protein that is cleaved by plasma kallikrein in the clinical settings of sepsis and chronic inflammatory diseases such as rheumatoid arthritis and Crohn's disease. This proteolytic event results in a nonapeptide, bradykinin (BK), and a kinin-free derivative of HK, namely HKa.
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Antisense Inhibition of the Brain Kallikrein-Kinin System
Hypertension, 1996We used antisense oligodeoxynucleotide (ODN) strategy, based on interference of information flow from gene to protein, to determine the role of kininogen and bradykinin B2receptor genes in the pathogenesis of genetic hypertension in rats. Mean blood pressure of 9-week-old spontaneously hypertensive rats (SHR) increased 4 hours after acute ...
MADEDDU P +4 more
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The Kallikrein-Kinin System and Hypertension
2007Tissue (glandular or renal) kallikrein (E.C. 3.4.21.35) belongs to a subgroup of serine proteinases and processes low molecular weight kininogen substrate to release vasoactive kinin peptides (1). The well-recognized function of tissue kallikrein is mediated by lysyl-bradykinin (Lys-BK or kallidin) and bradykinin (BK), which consist of 10 and 9 amino ...
Julie Chao, Lee Chao
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Kallikrein-Kinin System in Infectious Diseases
1989Infectious disease including those caused by viruses, rickettsia, fungi, parasites and bacteria are known to be associated with hemostatic disorders1 including disseminated intravascular coagulation (DIC). This paper will concentrate on the pathogenesis of the coagulation abnormalities in particular changes in surface mediated events of plasma ...
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Tissue Kallikrein–Kinin System
Comprehensive Physiology, 1999Abstract The sections in this article are: Historical Perspectives Kallikrein–Kinin Systems Plasma Kallikrein–Kinin System Tissue ...
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[Prostaglandin and kallikrein-kinin systems].
Nihon rinsho. Japanese journal of clinical medicine, 1997We reviewed the recent advances in the molecular characterization of prostanoid and bradykinin receptors. Prostanoids and bradykinin exert versatile actions in diverse tissues and cells through specific cell surface receptors. Molecular biological studies revealed the primary structure of eight types and subtypes of prostanoid receptors from various ...
H, Yoshida, N, Ura, K, Shimamoto
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The renal kallikrein-kinin system
American Journal of Physiology-Renal Physiology, 1980O A, Carretero, A G, Scicli
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