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Donidalorsen for the Treatment of Hereditary Angioedema: A Review of Clinical Studies. [PDF]
Drug Des Devel TherRiedl MA +7 more
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The bradykinin B2 receptor as a context-dependent modulator of neural circuit function. [PDF]
Front Cell NeurosciSilva JLS +3 more
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Endothelial triple-pathway vasorelaxation as an adjunctive strategy in resistant hypertension. [PDF]
J HypertensMadeddu P +3 more
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Cardiovascular Properties of the Kallikrein-Kinin System
Current Medical Research and Opinion, 2002All the components of the kallikrein-kinin system are located in the vascular smooth muscle as well as in the heart. In recent years, numerous observations obtained from clinical and experimental models of diabetes, hypertension, cardiac failure, ischaemia, myocardial infarction and left ventricular hypertrophy, have suggested that the reduced activity
Jagdish N Sharma
exaly +3 more sources
PHARMACOLOGY OF THE KALLIKREIN–KININ SYSTEM
Pharmacological Research, 1997---
REGOLI, Domenico +2 more
openaire +3 more sources
2011
Emerging evidence suggests a role of the kallikrein-kinin system (KKS) in the pathogenesis of diabetic nephropathy (DN). Tissue kallikrein 1 is a member of the tissue kallikrein family that is mainly responsible for the generation of kinins, and bradykinin (BK) is the principal kinin responsible for the biologic actions of the KKS that acts through the
Leung, JCK, Lai, KN, Tang, SCW
openaire +4 more sources
Emerging evidence suggests a role of the kallikrein-kinin system (KKS) in the pathogenesis of diabetic nephropathy (DN). Tissue kallikrein 1 is a member of the tissue kallikrein family that is mainly responsible for the generation of kinins, and bradykinin (BK) is the principal kinin responsible for the biologic actions of the KKS that acts through the
Leung, JCK, Lai, KN, Tang, SCW
openaire +4 more sources
Tonin and Kallikrein-Kinin System
1989The kininogenase activity of tonin has been demonstrated by Ikeda and Arakawa, 1984. Tonin of the rat submandibular gland contracts the rat uterus independent of addition of the substrate. On repetition, the same dose of enzyme elicited desensitization. When a double dose was used the contraction again occurred.
M H, Feitosa +5 more
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The Kallikrein-Kinin System in Inflammation
1989The kallikrein kinin system is shown diagrammatically in Figure 1 and indicates the various pathways by which kinin (bradykinin or lysyl bradykinin) can be formed. The intrinsic coagulation-kinin system is depicted on the left, and the tissue kallikrein-kinin pathway on the right.
A P, Kaplan +4 more
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