Results 61 to 70 of about 178,982 (291)
Programmatically selected multidrug-resistant strains drive the emergence of extensively drug-resistant tuberculosis in South Africa [PDF]
, 2013 South Africa shows one of the highest global burdens of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). Since 2002, MDR-TB in South Africa has been treated by a standardized combination therapy, which until 2010 included
Pillay, Manormoney +41 more
core +2 more sources
Advanced Science, EarlyView.Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung +39 more
wiley +1 more source
Advanced Science, EarlyView.This study presents a computational tunnel engineering strategy in Fe(II)/α‐ketoglutarate‐dependent dioxygenases (αKGDs) to enhance oxygen (O2) transport, an essential molecule for αKGDs, and limit hydrogen peroxide (H2O2) entry, an inhibitor from the αKG supply system.
Huan Liu +10 more
wiley +1 more source
Aminoglycoside-induced hearing deficits – a review of cochlear ototoxicity
South African Family Practice, 2015 This article aims to inform the reader about current knowledge of the effects of aminoglycosides on hearing. The hearing loss caused by aminoglycosides is permanent and can negatively affect the individual’s quality of life.
Lucretia Petersen, Christine Rogers
doaj +1 more source
Factors affecting gene transformation in mangosteen [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2003 Factors affecting gene transformation in mangosteen (Garcinia mangostana L.) were investigated. Types of explants, strains and densities of Agrobacterium tumefaciens, and co-culture methods were examined to optimize gene transformation.
Sompong Te-chato, Vitoon Chaipakdee
doaj
Modified Aminoglycosides Bind Nucleic Acids in High-Molecular-Weight Complexes
Antibiotics, 2020 Aminoglycosides represent a large group of antibiotics well known for their ability to target the bacterial ribosome. In studying 6”-substituted variants of the aminoglycoside tobramycin, we serendipitously found that compounds with C12 or C14 ...
Lanqing Ying +4 more
doaj +1 more source
Single‐Molecule Characterization of Bacterial Factor‐Dependent Transcription Activation by Rob
Advanced Science, EarlyView.Factor‐dependent transcription activation is crucial and involves complex interactions between transcription factors, RNA polymerase, and promoter DNA. Using single‐molecule assays, we show that Rob prebinds RNAP to facilitate promoter search and enhances DNA unwinding and promoter escape.
Yuqiong Zhang +7 more
wiley +1 more source
Divergent Synthesis of Three Classes of Antifungal Amphiphilic Kanamycin Derivatives
, 2016 A concise and novel method for site-selective alkylation of 1,3,6′,3″-tetraazidokanamycin has been developed that leads to the divergent synthesis of three classes of kanamycin A derivatives.
Jaya P. Shrestha (3223335) +23 more
core +1 more source
Advanced Science, EarlyView.A graphene‐based electrical biosensor enables rapid and highly sensitive detection of GHB at 100 fm in both standard solutions and artificial urine, providing reliable point‐of‐need screening for drug‐facilitated sexual assault. The platform demonstrates strong selectivity, fast response, and a wide dynamic range, supporting accurate detection in ...
Jai Eun An +8 more
wiley +1 more source
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source