A 3D Physical Model of Karyopherin‐β2
The FASEB Journal, 2012 Karyopherin beta 2 (Kapβ2) is an importin that transports various cargo proteins into the nucleus through interactions with nucleoporins, which are proteins of the nuclear pore complex (NPC). One might overlook the significance of this protein but it actually plays a crucial role in the human body.
Mary Acheampong +12 more
openaire +1 more source
Nuclear Import of Yeast Proteasomes
Cells, 2015 Proteasomes are highly conserved protease complexes responsible for the degradation of aberrant and short-lived proteins. In highly proliferating yeast and mammalian cells, proteasomes are predominantly nuclear.
Julianne Burcoglu +2 more
doaj +1 more source
MERS-CoV 4b protein interferes with the NF-κB-dependent innate immune response during infection. [PDF]
PLoS Pathogens, 2018 Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel human coronavirus that emerged in 2012, causing severe pneumonia and acute respiratory distress syndrome (ARDS), with a case fatality rate of ~36%.
Javier Canton +8 more
doaj +1 more source
Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport
Cells, 2018 Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology.
Friederike K. Kosyna, Reinhard Depping
doaj +1 more source
Advanced Science, Volume 12, Issue 23, June 20, 2025.Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong +15 more
wiley +1 more source
KPNA2 protein expression in invasive breast carcinoma and matched peritumoral ductal carcinoma in situ [PDF]
, 2018 The aim of this study was to evaluate protein expression of Karyopherin alpha 2 (KPNA2) in invasive breast cancer and matched ductal carcinoma in situ (DCIS) and to correlate it with clinicopathological data, including patient survival.
Dahl, Edgar +7 more
core
Cell Host-Microbe Interactions: Turning Pathogen Mechanisms Into Cell's Advantages [PDF]
, 2013 Host-Pathogen Interaction is a very vast field of biological sciences, indeed every year many un- known pathogens are uncovered leading to an exponential growth of this field.
Avanzi, Simone <1982>
core +1 more source
Advanced Science, Volume 12, Issue 20, May 29, 2025.Lactylation of UDP‐glucose dehydrogenase (UGDH) represses its enzymatic activity and causes glycosaminoglycans loss. In addition, UGDH lactylation facilitates its interaction with chromosome region maintenance 1 (CRM1) and promotes the nucleocytoplasmic transport.
Weiren Lan +8 more
wiley +1 more source
Pleomorphic adenoma gene 1 mediates the role of Karyopherin alpha 2 and has prognostic significance in hepatocellular carcinoma [PDF]
, 2014 Zhe-yuan Hu +4 more
openalex +2 more sources
Identifizierung von Gbp2p und Hrb1p als am nukleären mRNA-Export beteiligte Proteine und Analyse der zytoplasmatischen Umstrukturierungen exportierter mRNA-Proteinkomplexe [PDF]
, 2005 Der nukleäre mRNA-Export ist ein komplexer Vorgang, an dem zahlreiche Proteinfaktoren beteiligt sind. Pendelnde mRNA-Bindeproteine, welche in Assoziation mit den mRNA-Molekülen den Zellkern verlassen und daraufhin re-importiert werden, sind hierbei von ...
Müller, Rolf (Prof. Dr.) +1 more
core +1 more source