Results 121 to 130 of about 10,614 (241)

Visualizing and analyzing 3D biomolecular structures using Mol* at RCSB.org: Influenza A H5N1 virus proteome case study

Protein Science, Volume 34, Issue 4, April 2025.
Abstract The easiest and often most useful way to work with experimentally determined or computationally predicted structures of biomolecules is by viewing their three‐dimensional (3D) shapes using a molecular visualization tool. Mol* was collaboratively developed by RCSB Protein Data Bank (RCSB PDB, RCSB.org) and Protein Data Bank in Europe (PDBe ...
Sebastian Bittrich, Alexander S. Rose, David Sehnal, Jose M. Duarte, Yana Rose, Joan Segura, Dennis W. Piehl, Brinda Vallat, Chenghua Shao, Charmi Bhikadiya, Jesse Liang, Mark Ma, David S. Goodsell, Stephen K. Burley, Shuchismita Dutta   +14 more
wiley   +1 more source

Rtp1p Is a Karyopherin-Like Protein Required for RNA Polymerase II Biogenesis [PDF]

, 2013
The assembly and nuclear transport of RNA polymerase II (RNA pol II) are processes that require the participation of many auxiliary factors. In a yeast genetic screen, we identified a previously uncharacterized gene, YMR185w (renamed RTP1), which encodes
Ausubel FM, Boulon S, Boulon S, Burns N, Chook YM, Cingolani G, Cook AG, Cramer P, Czeko E, Edwards AM, Estruch F, Forget D, Garí E, Gavin AC, Giaever G, Graumann J, Görlich D, Imasaki T, Juanes MA, Kakihara Y, Kimura M, Krogan NJ, Lau D, Neville M, Pascual-García P, Peiró-Chova L, Peiró-Chova L, Pemberton LF, Reyes-Pardo H, Soriano-Carot M, Staresincic L, Strahm Y, Te J, Watanabe M, Wild T, Zhao R, Zhao R   +36 more
core   +1 more source

Elucidation of the binding interaction interface between AAV serotype 11 capsid protein and host nuclear import proteins

Molecular Therapy: Methods & Clinical Development
Adeno-associated viruses (AAVs) are widely acknowledged as versatile vectors for gene therapy due to their non-pathogenic nature, inherent capacity for tissue-specific targeting, and their potential for customizable engineering. The N terminus of the AAV
Mikayla Hoad, Sepehr Nematollahzadeh, Justin A. Roby, Gualtiero Alvisi, Jade K. Forwood   +4 more
doaj   +1 more source

Nucleocytoplasmic transport: taking an inventory [PDF]

, 2018
In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial and temporal separation of DNA replication and transcription from cytoplasmic protein synthesis.
Fried, H., Kutay, U.
core  

The Mammalian Cell Cycle Regulates Parvovirus Nuclear Capsid Assembly. [PDF]

, 2015
It is unknown whether the mammalian cell cycle could impact the assembly of viruses maturing in the nucleus. We addressed this question using MVM, a reference member of the icosahedral ssDNA nuclear parvoviruses, which requires cell proliferation to ...
Almendral, JM, Domínguez, C, Gil-Ranedo, J, Hernando, E, Kann, M, Riolobos, L   +5 more
core   +7 more sources

Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity.

PLoS ONE, 2011
The Karyopherin superfamily comprises nuclear transport proteins, involved in the shuttling of certain cargo proteins into and out of the nucleus. Karyopherin β1 (Kpnβ1) and Karyopherin α2 (Kpnα2) are importin proteins, which work in concert to transport
Pauline J van der Watt, Ellen Ngarande, Virna D Leaner   +2 more
doaj   +1 more source

Risks Posed by Reston, the Forgotten Ebolavirus [PDF]

, 2016
Out of the five members of the Ebolavirus family, four cause lifethreatening disease, whereas the fifth, Reston virus (RESTV), is nonpathogenic in humans. The reasons for this discrepancy remain unclear. In this review, we analyze the currently available
Arran Hamlet, Carolyn B. Coyne, Diego Cantoni, Jeremy S. Rossman, Mark N. Wass, Martin Michaelis   +5 more
core   +2 more sources

IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation

Journal of Experimental & Clinical Cancer Research, 2019
Background Karyopherin nuclear transport receptors play important roles in tumour development and drug resistance and have been reported as potential biomarkers and therapeutic targets for tumour treatment.
Wenjuan Zhang, Yanxia Lu, Xiaomin Li, Jianming Zhang, Weihao Lin, Wei Zhang, Lin Zheng, Xuenong Li   +7 more
doaj   +1 more source

The karyopherin CRM1 is required for dendritic cell maturation

Immunobiology, 2010
Dendritic cells (DC) are the most potent antigen-presenting cells (APC) of the immune system and are specialized to activate T as well as B cell-dependent immune responses. Mature DC are characterized by expression of CD83, a surface molecule that has been postulated to be required for efficient DC activity.
Jan, Chemnitz, Nadine, Turza, Ilona, Hauber, Alexander, Steinkasserer, Joachim, Hauber   +4 more
openaire   +2 more sources

Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

, 2023
Demetra P. Kelenis, Kathia E. Rodarte, Rahul K. Kollipara, Karine Pozo, Shreoshi Pal Choudhuri, Kyle B. Spainhower, Sarah J. Wait, Victor Stastny, Trudy G. Oliver, Jane E. Johnson   +9 more
openalex   +2 more sources