Results 111 to 120 of about 6,766 (259)

Metabolic Reprogramming: A Crucial Contributor to Anticancer Drug Resistance

MedComm, Volume 6, Issue 9, September 2025.
Role of metabolic reprogramming in drug resistance in cancer: Metabolic reprogramming in cancer cells profoundly impacts the responsiveness of these cells to drugs. Cancer cells rewire the flux of the metabolism of the three major nutrients, glucose, lipid, and amino acids, leading to abnormalities in drug orientation, defects in cell death mechanisms,
Yunhan Zhu, Weijie Yan, Lingfeng Tong, Jie Yang, Shengfang Ge, Jiayan Fan, Renbing Jia, Xuyang Wen   +7 more
wiley   +1 more source

The Ran pathway in Drosophila melanogaster mitosis

Frontiers in Cell and Developmental Biology, 2015
Over the last two decades, the small GTPase Ran has emerged as a central regulator of both mitosis and meiosis, particularly in the generation, maintenance and regulation of the microtubule (MT)-based bipolar spindle.
James G Wakefield, Jack Wei-Chu Chen, Amy eBarker, Amy eBarker   +3 more
doaj   +1 more source

Crystallographic and Biochemical Analysis of the Ran-Binding Zinc Finger Domain [PDF]

, 2009
The nuclear pore complex (NPC) resides in circular openings within the nuclear envelope and serves as the sole conduit to facilitate nucleocytoplasmic transport in eukaryotes.
Adams, Alam, Alber, Ball, Banatao, Bastos, Boehmer, Chook, Cook, Cooper, Crooks, D'Angelo, Denning, Dimaano, Edgar, Emsley, Fahrenkrog, Gamsjaeger, Gorlich, Higa, Hulo, James R. Partridge, Joseph, Kiseleva, Kiseleva, Krull, Laskowski, Lim, Loughlin, Matsuura, Meier, Mizutani, Nakielny, Otwinowski, Pante, Pichler, Ribbeck, Ribbeck, Salina, Schneider, Schrader, Schwartz, Shah, Shah, Stewart, Stewart, Sukegawa, Thomas U. Schwartz, Tran, Ullman, Vetter, Walther, Walther, Wang, Waterhouse, Weis, Wu, Yaseen, Yokoyama, Yu   +59 more
core   +1 more source

A cellular model of TDP‐43 induces phosphorylated TDP‐43 aggregation with distinct changes in solubility and autophagy dysregulation

The FEBS Journal, Volume 292, Issue 18, Page 4870-4897, September 2025.
TDP‐43 protein plays a pathological role in sporadic and familial amyotrophic lateral sclerosis (ALS). Here, we developed a cellular model overexpressing TDP‐43 with three mutations linked to familial ALS, termed ‘3X‐TDP‐43’. Mutant 3X‐TDP‐43 expression showed deficits in autophagy flux and colocalization with stress granules.
Matthew B. Dopler, Muhammad I. Abeer, Sanaz Arezoumandan, Keyshawn Cox, Tyler L. Petersen, Esther H. Daniel, Carlton L. Cannon III, Angelica Bautista, Kennedy D. Blancher, Alysia M. Bland, Kylie J. Bond, Dominque A. Davis, Jessica M. Francois, Eliana J. McCray, Justin M. Morgan, Jessica L. Pulliam, Zymir A. Robinson, Mykia J. Taylor, James A. Dowell, Nigel J. Cairns, Michael A. Gitcho   +20 more
wiley   +1 more source

Karyopherin β2B participates in mRNA export from the nucleus [PDF]

Proceedings of the National Academy of Sciences, 2002
Transport of macromolecules between the cell nucleus and cytoplasm occurs through the nuclear pores and is mediated by soluble carriers known as karyopherins (Kaps), transportins, importins, or exportins. We report that Kap β2B (transportin-2) forms complexes with the mRNA export factor TAP in the presence of RanGTP, as shown by ...
Monee K, Shamsher, Jonathan, Ploski, Aurelian, Radu   +2 more
openaire   +2 more sources

Non-centrosomal TPX2-dependent regulation of the Aurora A kinase: functional implications for healthy and pathological cell division

Frontiers in Oncology, 2016
Aurora A has been extensively characterized as a centrosomal kinase with essential functions during cell division including centrosome maturation and separation and spindle assembly. However, Aurora A localization is not restricted to the centrosomes and
Isabelle eVernos, Isabelle eVernos, Isabelle eVernos, Isabelle eVernos, Georgina eGarrido, Georgina eGarrido, Georgina eGarrido   +6 more
doaj   +1 more source

Kapβ2 Reverses Sevoflurane‐Induced Hydrogel Phase Transition of hnRNPA2/B1‐SG in Hypoxic Primary Rat Hippocampal Neurons

CNS Neuroscience &Therapeutics, Volume 31, Issue 8, August 2025.
Sevoflurane exacerbates hippocampal neuronal dysfunction under hypoxic conditions by inducing the cytoplasmic mislocalization of hnRNPA2/B1, which drives abnormal liquid–liquid phase separation (LLPS) and subsequent irreversible hydrogel transition of hnRNPA2/B1‐containing stress granules (SGs).
Miao Zhang, Xinyi Wang, Feiyu Jia, Chenyi Yang, Zixuan Wang, Huihui Liao, Lin Zhang, Xi Xin, Haiyun Wang   +8 more
wiley   +1 more source

Karyopherin-βs play a key role as a phase separation regulator [PDF]

, 2021
Takuya Yoshizawa, Lin Guo
openalex   +1 more source

Developmental regulation of the heat shock response by nuclear transport factor karyopherin-α3 [PDF]

, 2001
During early stages of Drosophila development the heat-shock response cannot be induced. It is reasoned that the adverse effects on cell cycle and cell growth brought about by Hsp70 induction must outweigh the beneficial aspects of Hsp70 induction in the
Chen, Tianxin, Fang, Xiang-dong, Parker, Carl S., Tran, Kim   +3 more
core  

Membrane-coating lattice scaffolds in the nuclear pore and vesicle coats: Commonalities, differences, challenges [PDF]

, 2011
The nuclear pore complex (NPC) regulates all traffic between the cytoplasm and the nucleus. It is a large protein assembly composed of multiple copies of ~30 nucleoporins (nups).
Leksa, Nina Carolina, Schwartz, Thomas
core   +1 more source