Results 171 to 180 of about 17,716 (217)

Modulation of vascular KATP channels in hypothyroidism

European Journal of Pharmacology, 1996
The role of vascular KATP channels in hypothyroidism-induced decrease in myogenic activity of rat portal vein was examined by using pharmacologically relevant concentrations of K+ channel ligands. As compared to controls, a significant decrease in the myogenic tone and noradrenaline (10(-9)-10(-5) M)-induced contractions was observed in portal veins ...
M, Jagadish, V, Raviprakash, A G, Telang, S K, Mishra   +3 more
openaire   +2 more sources

Molecular determinants of KATP channel inhibition by ATP [PDF]

EMBO Journal, 1998
ATP-sensitive K+ (KATP) channels are both inhibited and activated by intracellular nucleotides, such as ATP and ADP. The inhibitory effects of nucleotides are mediated via the pore-forming subunit, Kir6.2, whereas the potentiatory effects are conferred by the sulfonylurea receptor subunit, SUR.
Stephen J Tucker, Fiona M Gribble, Peter Proks   +2 more
exaly   +4 more sources

KATP channel mutations in congenital hyperinsulinism

Seminars in Pediatric Surgery, 2011
Adenosine triphosphate (ATP)-sensitive potassium channels (K(ATP) channels) have a central role in the regulation of insulin secretion in pancreatic β cells. They are octameric complexes organized around the central core constituted by the Kir6.2 subunits. The regulation of the channel itself takes place on the sulfonylurea receptor-1 subunit.
Cécile, Saint-Martin, Jean-Baptiste, Arnoux, Pascale, de Lonlay, Christine, Bellanné-Chantelot   +3 more
openaire   +2 more sources

KATP channels in vascular smooth muscle

Cardiovascular Research, 1994
ATP sensitive potassium channels (KATP channels) appear widely distributed in the vascular system. At the single channel level, channels with both small and large conductance have been described, though the former appear to be activated by potassium channel openers or ATP depletion in whole cell studies.
J M, Quayle, N B, Standen
openaire   +2 more sources

Pharmacological modulation of KATP channels

Biochemical Society Transactions, 2001
Pharmacological modulation of ATP-sensitive K+ (KATP) channels is used in the treatment of a number of clinical conditions, including type 2 diabetes and angina. The sulphonylureas and related drugs, which are used to treat type 2 diabetes, stimulate insulin secretion by closing KATP channels in pancreatic β-cells.
F. M. Gribble, F. Reimann
openaire   +1 more source

Brain glucosensing and the KATP channel

Nature Neuroscience, 2001
An ATP-sensitive K+ channel in glucose-responsive neurons is shown to be required for the emergency response to severe glucose deprivation, but not necessarily for normal feeding.
Barry E. Levin, Ambrose A. Dunn-Meynell, Vanessa H. Routh   +2 more
openaire   +1 more source

Pharmacology and Structure-Activity Relationships for KATP Modulators

Journal of Cardiovascular Pharmacology, 1994
KATP openers are recognized as having a therapeutic potential for the treatment of various cardiovascular and noncardiovascular diseases. However, the first-generation agents open KATP in a variety of tissues that limit their potential clinical utility.
openaire   +2 more sources

The Biology of KATP Channels

1995
ATP-sensitive potassium channels (KATP channels) provide a mechanism for linking membrane potassium permeability to cellular metabolism. They have important functions in the tissues of central importance to this book, cardiac muscle and systemic and coronary vascular smooth muscle.
openaire   +1 more source

Clinical Exploitation of the KATP Channel

1995
Potassium ion (K+) channels play a dominant role in controlling the resting membrane potential of excitable cells. They are ubiquitous, structurally diverse and functionally are perhaps most usefully classified by what causes them to open or close.
Henry Purcell, Kim Fox
openaire   +1 more source

Bepridil, an Antiarrhythmic Drug, Opens Mitochondrial KATP Channels, Blocks Sarcolemmal KATP Channels, and Confers Cardioprotection

The Journal of Pharmacology and Experimental Therapeutics, 2006
Bepridil, which is clinically useful in the treatment of arrhythmias, has been reported to inhibit sarcolemmal ATP-sensitive K(+) (sarcK(ATP)) channels. However, the effect of bepridil on mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channels remains unclear.
Toshiaki, Sato, Alexandre D T, Costa, Tomoaki, Saito, Takehiko, Ogura, Hideyuki, Ishida, Keith D, Garlid, Haruaki, Nakaya   +6 more
openaire   +2 more sources