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Imaging and Quantification of Recycled KATP Channels
2013This chapter describes immunochemistry-based methods to investigate recycling of membrane proteins at the cell surface. Two methods are described, one qualitative and the other quantitative. Both methods consist of two rounds of extracellular antibody capture.
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Vascular Pathology and The KATP Channel
1995K+ channels determine the resting membrane potential and cellular excitability of most cells [1], The opening of K+ channels shifts the membrane potential towards the K+ equilibrium potential which is around -90 mV. In excitable cells endowed with depolarization-activated Ca2+ channels (voltage-gated Ca2+ channels, VOCCs), hyperpolarization will ...
Ulrich Quast, Stefan Glocker
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KATP channels and basal coronary vascular tone
Cardiovascular Research, 1994After reviewing recent experimental work from various laboratories we have come to the following conclusions. (1) An increase in transmural pressure causes depolarisation of coronary arterioles, which increases smooth muscle tone. Under these conditions the opening of KATP channels can induce a much larger change in membrane potential than in relaxed ...
J, Daut +3 more
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KATP channels in ischaemic preconditioning
Cardiovascular Research, 1994J R, Parratt, K A, Kane
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The KATP Channel and the Sulfonylurea Receptor
2001ATP-sensitive K+ channels (KAgp channels) were first described in cardiac myocytes (1) and were subsequently found in many other tissues including pancreatic 13-cells (25), skeletal muscle (6), smooth muscle (7), brain (8), pituitary (9), and kidney (10) and in mitochondria (11).
Susumu Seino, Takashi Miki, Hideki Yano
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KATP channels as molecular sensors of cellular metabolism
Nature, 2006In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (K(ATP)) channel activity provides a unique link between cellular energetics and electrical excitability. Over the past ten years, a steady drumbeat of crystallographic and electrophysiological studies has led to detailed structural and kinetic models that define the molecular ...
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Molecular structure of an open human K ATP channel
Proceedings of the National Academy of Sciences of the United States of America, 2021Chen Zhao +2 more
exaly
Caveolin-3 negatively regulates endocytic recycling of cardiac KATP channels
American Journal of Physiology - Cell Physiology, 2023Hua-Qian Yang
exaly