Results 211 to 220 of about 56,140 (348)

Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells. [PDF]

Nat Commun
Han L, Qiu Y, He L, Gao C, Zhou N, Fu X, Xu J, Lin L, Wang H, Biswal S, Wu Z.   +10 more
europepmc   +1 more source

Tussilagone attenuated cigarette smoke-induced chronic obstructive pulmonary disease through regulating Nrf2 and NF-κB/NLRP3 inflammasome via directly targeting cysteine 434 of KEAP1

Lin‐Tao Xu, Qing‐Tong Han, Zhen-Peng Xu, Xiaoning Wang, Hua Zhang, Tao Shen   +5 more
openalex   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Effects of the Pharmacological Modulation of NRF2 in Cancer Progression. [PDF]

Medicina (Kaunas)
Gelerstein-Claro S, Méndez-Valdés G, Rodrigo R.   +2 more
europepmc   +1 more source

Mechanism of Lenvatinib Resistance via Exosomal miRNA‐132/Nrf2 Axis in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, Volume 10, Issue 1, Page 178-186, January 2026.
Exosomal miRNA‐132 from LVT‐res HCC cells activated Nrf2 expression through the PTEN/GSK3β pathway in recipient cells. This cascade could induce drug resistance in non‐resistant HCC cells in the TME. ABSTRACT Introduction Lenvatinib is a multiple receptor tyrosine kinase inhibitor and a first‐line targeted therapy for hepatocellular carcinoma (HCC ...
Chie Takasu, Chiharu Nakasu, Yu Saito, Yuji Morine, Tetsuya Ikemoto, Shinichiro Yamada, Hiroki Teraoku, Mitsuo Shimada   +7 more
wiley   +1 more source

Synthetic Oleanane Triterpenoids Reduce Tumor Growth and Promote an Anti-Tumor Immune Response Independent of Cancer <i>KEAP1</i> Mutational Status. [PDF]

Antioxidants (Basel)
Occhiuto CJ, Moerland JA, Liby KT, Leal AS.   +3 more
europepmc   +1 more source

All-trans retinoic acid enhances temozolomide-induced autophagy in human glioma cells U251 via targeting Keap1/Nrf2/ARE signaling pathway

, 2017
Lin Shi, Hongyuan Li, Zhan Yang
openalex   +2 more sources

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo, Zhangxiu Liao, Shuangxia Zhang   +2 more
wiley   +1 more source

Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing <i>STING</i>/<i>MDA5</i> expression and interferon signaling in lung cancers harboring <i>KEAP1</i>/<i>STK11</i> mutations. [PDF]

Front Oncol
Shrestha A, Li Y, Huang L, Li S, Zhou Y, Gu J, Lin Z.   +6 more
europepmc   +1 more source

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source