Iron oxide-coupled CRISPR-nCas9-based genome editing assessment in mucopolysaccharidosis IVA mice
Molecular Therapy: Methods & Clinical Development, 2023 Mucopolysaccharidosis (MPS) IVA is a lysosomal storage disorder caused by mutations in the GALNS gene that leads to the lysosomal accumulation of keratan sulfate (KS) and chondroitin 6-sulfate, causing skeletal dysplasia and cardiopulmonary complications.
Andrés Felipe Leal +5 more
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Bisphosphonate Treatment in a Patient Affected by MPS IVA with Osteoporotic Phenotype
Case Reports in Medicine, 2013 Morquio A syndrome (Mucopolysaccharidosis type IVA) (MPS IVA) is a rare inherited metabolic disorder characterized by the defective degradation of keratan sulfate and chondroitin-6-sulfate.
Albina Tummolo +7 more
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Structural Characterization and Anticoagulant Activities of a Keratan Sulfate-like Polysaccharide from the Sea Cucumber Holothuria fuscopunctata. [PDF]
Mar Drugs, 2023 Chen R +7 more
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Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model. [PDF]
J Biol Chem, 2023 Ohkawa Y +8 more
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Natural history of Morquio A patient with tracheal obstruction from birth to death
Molecular Genetics and Metabolism Reports, 2018 Morquio A syndrome (mucopolysaccharidosis IVA, MPS IVA) is a lysosomal storage disease caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase, resulting in systemic accumulation of the partially degraded glycosaminoglycans (GAGs), keratan ...
Caitlin Doherty +6 more
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Transport studies of chondroitin sulfate disaccharide through articular cartilage [PDF]
, 1997 Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.Includes bibliographical references (leaves 56-57).by Julianne Jiang Zhu.M ...
Zhu, Julianne Jiang
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Glycosaminoglycans: Sweet as Sugar Targets for Topical Skin Anti-Aging
Clinical, Cosmetic and Investigational Dermatology, 2021 Siew Tein Wang, Boon Hoe Neo, Richard J Betts L’Oréal Research & Innovation, L’Oréal Singapore, SingaporeCorrespondence: Richard J Betts Email richard.betts@rd.loreal.comAbstract: Glycosaminoglycans (GAGs) are long, linear polysaccharides comprised of ...
Wang ST, Neo BH, Betts RJ
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The relationship between keratan sulfate glycosaminoglycan density and mechanical stiffening of CXL treatment. [PDF]
Exp Eye Res, 2023 Hatami-Marbini H, Emu ME.
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716 BIOCHEMICAL DEFECT OF NON-KERATAN-SULFATE-EXCRETING MORQUIO SYNDROME [PDF]
, 1981 Atsuko Fujimoto, Allen L. Horwitz
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Molecular Therapy: Methods & Clinical DevelopmentMucopolysaccharidosis type IVA (MPS IVA) is caused by a deficiency of N-acetyl-galactosamine-6-sulfate sulfatase (GALNS), leading to the accumulation of keratan sulfate and chondroitin-6-sulfate and development of severe skeletal dysplasia.
Shaukat A. Khan +4 more
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