Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model. [PDF]
J Biol Chem, 2023 Ohkawa Y +8 more
europepmc +3 more sources
Synthesis of biotinylated keratan sulfate repeating disaccharides [PDF]
Bioscience, Biotechnology, and Biochemistry, 2014 Abstract We synthesized four types of keratan and keratan sulfate repeating disaccharides containing non-sulfate, Galβ1-4GlcNAcβ, and three types of sulfates, Gal6Sβ1-4GlcNAcβ, Galβ1-4GlcNAc6Sβ, and Gal6Sβ1-4GlcNAc6Sβ in an efficient and stereo-controlled manner. These disaccharides were conjugated with biotin via a hydrophilic linker at
N. Takeda, J. Tamura
semanticscholar +3 more sources
GlcNAc6ST2/CHST4 Is Essential for the Synthesis of R-10G-Reactive Keratan Sulfate/Sulfated N-Acetyllactosamine Oligosaccharides in Mouse Pleural Mesothelium [PDF]
MoleculesWe recently showed that 6-sulfo sialyl N-acetyllactosamine (LacNAc) in O-linked glycans recognized by the CL40 antibody is abundant in the pleural mesothelium under physiological conditions and that these glycans undergo complementary synthesis by ...
Yoshiko Takeda-Uchimura +6 more
doaj +2 more sources
Metabolic reprogramming and M2 macrophage depletion define the microenvironment of adenomyosis [PDF]
Frontiers in EndocrinologyBackgroundAdenomyosis is a chronic gynecological disorder characterized by the invasion of endometrial tissues into the myometrium of the uterus, with pathophysiology linked to chronic inflammation and metabolic dysregulation.
Xuejiao Bian +7 more
doaj +2 more sources
Residual keratan sulfate in chondroitin sulfate formulations for oral administration
Carbohydrate Polymers, 2012 Chondroitin sulfate is a biomedical glycosaminoglycan (GAG) mostly used as a dietary supplement. We undertook analysis on some formulations of chondroitin sulfates available for oral administration. The analysis was based on agarose-gel electrophoresis, strong anion-exchange chromatography, digestibility with specific GAG lyases, uronic acid content ...
Vitor H Pomin
exaly +3 more sources
Keratan Sulfate Glycosaminoglycans in Murine Eosinophil-specific Granules [PDF]
Journal of Histochemistry & Cytochemistry, 1999 We examined the presence of sialyl glycoconjugates in specific granules from murine bone marrow eosinophils. Lectin cytochemistry using Maackia amurensis lectin II (MAL II) specific for sialyl α-2,3 galactose residues demonstrated positive labeling in both immature and mature specific granules. Pretreatment with Clostridium neuraminidase or keratanase
J, Ohmori +4 more
openaire +3 more sources
Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes. [PDF]
PLoS ONE, 2020 Diabetes is the leading cause of end-stage renal disease worldwide. Our understanding of the early kidney response to chronic hyperglycemia remains incomplete.
Julie A D Van +10 more
doaj +2 more sources
Distribution of proteoglycans antigenically related to corneal keratan sulfate proteoglycan [PDF]
, 1987 Three antibodies reacting with corneal keratan sulfate proteoglycan were used to detect antigenically related molecules in 11 bovine and 13 embryonic chick tissues. Two monoclonal antibodies recognized sulfated epitopes on the keratan sulfate chain and a
Caterson, B +2 more
core +3 more sources
Identification of keratan sulfate disaccharide at C-3 position of glucuronate of chondroitin sulfate from Mactra chinensis. [PDF]
Biochem J, 2016 Glycosaminoglycans (GAGs), including chondroitin sulfate (CS), dermatan sulfate, heparin, heparan sulfate and keratan sulfate (KS) are linear sulfated repeating disaccharide sequences containing hexosamine and uronic acid [or galactose (Gal) in the case ...
Higashi K +6 more
europepmc +2 more sources
Characterization and Determination of Human Urinary Keratan Sulfate.
Chemical and Pharmaceutical Bulletin, 1998 Keratan sulfate was isolated from normal human urine and was characterized by sugar compositional analysis and H-NMR spectroscopy. It was found that KS from human urine is classified as skeletal type (KS-II type chain) with an O-glycosidic linkage between galactosamine and serine (or threonine).
H, Toyoda +5 more
openaire +4 more sources