Results 21 to 30 of about 413,051 (232)

Residual keratan sulfate in chondroitin sulfate formulations for oral administration

Carbohydrate Polymers, 2012
Chondroitin sulfate is a biomedical glycosaminoglycan (GAG) mostly used as a dietary supplement. We undertook analysis on some formulations of chondroitin sulfates available for oral administration. The analysis was based on agarose-gel electrophoresis, strong anion-exchange chromatography, digestibility with specific GAG lyases, uronic acid content ...
Vitor H Pomin
exaly   +3 more sources

Urinary proteomics links keratan sulfate degradation and lysosomal enzymes to early type 1 diabetes. [PDF]

PLoS ONE, 2020
Diabetes is the leading cause of end-stage renal disease worldwide. Our understanding of the early kidney response to chronic hyperglycemia remains incomplete.
Julie A D Van, Sergi Clotet-Freixas, Anne-Christin Hauschild, Ihor Batruch, Igor Jurisica, Yesmino Elia, Farid H Mahmud, Etienne Sochett, Eleftherios P Diamandis, James W Scholey, Ana Konvalinka   +10 more
doaj   +2 more sources

Identification of keratan sulfate disaccharide at C-3 position of glucuronate of chondroitin sulfate from Mactra chinensis. [PDF]

Biochem J, 2016
Glycosaminoglycans (GAGs), including chondroitin sulfate (CS), dermatan sulfate, heparin, heparan sulfate and keratan sulfate (KS) are linear sulfated repeating disaccharide sequences containing hexosamine and uronic acid [or galactose (Gal) in the case ...
Higashi K, Takeda K, Mukuno A, Okamoto Y, Masuko S, Linhardt RJ, Toida T.   +6 more
europepmc   +2 more sources

Ablation of keratan sulfate accelerates early phase pathogenesis of ALS.

PLoS ONE, 2013
Biopolymers consist of three major classes, i.e., polynucleotides (DNA, RNA), polypeptides (proteins) and polysaccharides (sugar chains). It is widely accepted that polynucleotides and polypeptides play fundamental roles in the pathogenesis of ...
Kenichi Hirano, Tomohiro Ohgomori, Kazuyoshi Kobayashi, Fumiaki Tanaka, Tomohiro Matsumoto, Takamitsu Natori, Yukihiro Matsuyama, Kenji Uchimura, Kazuma Sakamoto, Hideyuki Takeuchi, Akihiro Hirakawa, Akio Suzumura, Gen Sobue, Naoki Ishiguro, Shiro Imagama, Kenji Kadomatsu   +15 more
doaj   +2 more sources

Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis

Cell Death and Disease, 2013
Experimental autoimmune neuritis (EAN) is an animal model of Guillain–Barré syndrome, an inflammatory demyelination disease of the peripheral nervous system.
Hiroki Matsui, Tomohiro Ohgomori, Takamitsu Natori, Katsuichi Miyamoto, Susumu Kusunoki, Kazuma Sakamoto, Naoki Ishiguro, S. Imagama, Kenji Kadomatsu   +8 more
exaly   +2 more sources

Airway glycomic and allergic inflammatory consequences resulting from keratan sulfate galactose 6-O-sulfotransferase (CHST1) deficiency. [PDF]

Glycobiology, 2018
Kumagai T, Kiwamoto T, Brummet ME, Wu F, Aoki K, Zhu Z, Bochner BS, Tiemeyer M.   +7 more
europepmc   +2 more sources

A multi-analytical approach to better assess the keratan sulfate contamination in animal origin chondroitin sulfate

Analytica Chimica Acta, 2017
Odile Francesca Restaino, Emiliano Bedini, Michelangelo Parrilli   +2 more
exaly   +2 more sources

Glycan Epitopes on 201B7 Human-Induced Pluripotent Stem Cells Using R-10G and R-17F Marker Antibodies

Biomolecules, 2021
We developed two human-induced pluripotent stem cell (hiPSC)/human embryonic stem cell (hESC)-specific glycan-recognizing mouse antibodies, R-10G and R-17F, using the Tic (JCRB1331) hiPSC line as an antigen. R-10G recognizes a low-sulfate keratan sulfate,
Yuko Nagai, Hiromi Nakao, Aya Kojima, Yuka Komatsubara, Yuki Ohta, Nana Kawasaki, Nobuko Kawasaki, Hidenao Toyoda, Toshisuke Kawasaki   +8 more
doaj   +1 more source

Differentiation of Human Embryonic Stem Cells into Cells with Corneal Keratocyte Phenotype [PDF]

, 2013
Corneal transparency depends on a unique extracellular matrix secreted by stromal keratocytes, mesenchymal cells of neural crest lineage. Derivation of keratocytes from human embryonic stem (hES) cells could elucidate the keratocyte developmental pathway
Chan, AA, Davoli, KA, Du, Y, Funderburgh, JL, Funderburgh, ML, Hertsenberg, AJ, Mann, MM, Mich-Basso, JD, Yang, L   +8 more
core   +9 more sources

Human Corneal Keratan Sulfates [PDF]

Journal of Biological Chemistry, 1997
The keratan sulfate-containing proteoglycans were isolated from fourteen pooled human corneas (thirteen from 61- to 86-year-olds, plus one from a 12-year-old). These proteoglycans were subjected to digestion with the enzyme keratanase II, and the released oligosaccharides, which included nonreducing termini and repeat region oligosaccharides but not ...
Tai, G H, Nieduszynski, I A, Fullwood, N J, Huckerby, T N   +3 more
openaire   +2 more sources