Results 31 to 40 of about 10,759 (233)
Novel Insight Into Glycosaminoglycan Biosynthesis Based on Gene Expression Profiles
Frontiers in Cell and Developmental Biology, 2021 Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, heparan sulfate, and keratan sulfate, except for hyaluronan that is a free polysaccharide, are covalently attached to core proteins to form proteoglycans.
Yi-Fan Huang +2 more
doaj +1 more source
Glycan Node Analysis of Plasma-Derived Extracellular Vesicles
Cells, 2020 Blood plasma is a readily accessible source of extracellular vesicles (EVs), i.e., cell-secreted nanosized carriers that contain various biomolecules, including glycans.
Sierra A. Walker +6 more
doaj +1 more source
The Linkage Region of Cartilage Keratan Sulfate to Protein
Journal of Biological Chemistry, 1974 Abstract Glycopeptides derived from bovine nasal septum keratan sulfate by acid hydrolysis and gel chromatography are shown to be enriched in the carbohydrate-protein linkage region. The effects of alkali on these glycopeptides are compared to the effects on the starting material.
Fred J. Kieras
openalex +4 more sources
Glycosaminoglycans in the human cornea: age-related changes [PDF]
, 2015 AIM: To investigate possible age-related changes in glycosaminoglycans (GAGs) in the human cornea. The substances today called GAGs were previously referred to as mucopolysaccharides.
Anello, Giulia +6 more
core +2 more sources
Keratan sulfate, a complex glycosaminoglycan with unique functional capability. [PDF]
Glycobiology, 2018 From an evolutionary perspective keratan sulfate (KS) is the newest glycosaminoglycan (GAG) but the least understood. KS is a sophisticated molecule with a diverse structure, and unique functional roles continue to be uncovered for this GAG. The cornea is the richest tissue source of KS in the human body but the central and peripheral nervous systems ...
Caterson B, Melrose J.
europepmc +5 more sources
International Journal of Experimental Pathology, 2004 Introduction The objective of this study was to make monoclonal antibodies specific for keratanase‐generated neoepitopes in keratan sulfate (KS) and to use them along with existing KS monoclonal antibodies (e.g. 5D4, IB4) to investigate KS sulfation pattern motifs in connective tissue proteoglycans during development, ageing and disease.Methods ...
Briedgeen Kerr +2 more
openalex +3 more sources
Journal of Biological Chemistry, 1975 A glycosidase which attacks corneal keratan sulfate was purified from extracts of Pseudomonas sp. IFO-13309. When corneal keratan sulfate was degraded by the purified enzyme, Sephadex G-50 chromatography indicated the presence of a number of oligosaccharides differing in size and sulfate content.
K Nakazawa, S Suzuki
openaire +3 more sources
Establishment of Glycosaminoglycan Assays for Mucopolysaccharidoses
Metabolites, 2014 Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders caused by deficiency of the lysosomal enzymes essential for catabolism of glycosaminoglycans (GAGs).
Shunji Tomatsu +13 more
doaj +1 more source
Efficacy and safety of enzyme replacement therapy with BMN 110 (elosulfase alfa) for Morquio A syndrome (mucopolysaccharidosis IVA): a phase 3 randomised placebo-controlled study. [PDF]
, 2014 ObjectiveTo assess the efficacy and safety of enzyme replacement therapy (ERT) with BMN 110 (elosulfase alfa) in patients with Morquio A syndrome (mucopolysaccharidosis IVA).MethodsPatients with Morquio A aged ≥5 years (N = 176) were randomised (1:1:
A McDonald +43 more
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Orthopedic management of the extremities in patients with Morquio A syndrome. [PDF]
, 2014 BackgroundMusculoskeletal involvement in Morquio A syndrome (mucopolysaccharidosis IVA; MPS IVA) contributes significantly to morbidity and mortality. While the spinal manifestations of the disorder have received considerable attention in the literature,
Bache, C Edward +6 more
core +1 more source