Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation [PDF]
, 2020 Aberrant detection of endogenous nucleic acids by the immune system can cause inflammatory disease. The scaffold function of the signaling kinase RIPK1 limits spontaneous activation of the nucleic acid sensor ZBP1.
De Munck, Jolien +12 more
core +2 more sources
Skin grafts : local quest for viable alternatives to autologous grafts using silk and acellular dermal matrices [PDF]
, 2014 The gold standard with regards to skin transplantation is the use of the patient’s own skin obtained from a healthy donor site. Such grafts can be either full thickness skin or more commonly nowadays, split thickness skin.
Gialanzè, Yanika +2 more
core +1 more source
The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer
Cells, 2020 The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival ...
Manel B. Hammouda +3 more
doaj +1 more source
Establishment of an In Vitro Scab Model for Investigating Different Phases of Wound Healing
Bioengineering, 2022 Chronic wounds are a serious problem in clinical work and a heavy burden for individuals and society. In order to develop novel therapies, adequate model systems for the investigation of wound healing are required.
Chao Liu +5 more
doaj +1 more source
Breast tumor kinase (Brk/PTK6) plays a role in the differentiation of primary keratinocytes [PDF]
, 2011 This work was supported by a project grant from the Biotechnology and Biological Sciences Research Council, UKBreast Tumor Kinase (Brk/PTK6) has a relatively limited expression profile in normal tissue.
Crompton, MR, Harvey, AJ, Tupper, J
core +2 more sources
Keratinocytes mediate innocuous and noxious touch via ATP-P2X4 signaling
eLife, 2018 The first point of our body’s contact with tactile stimuli (innocuous and noxious) is the epidermis, the outermost layer of skin that is largely composed of keratinocytes.
Francie Moehring +8 more
semanticscholar +1 more source
International Journal of Dentistry, 2011 Potentially malignant oral leukoplakias arise within precancerized epithelial fields consisting of cytogenetically altered keratinocytes at various stages of transformation.
L. Feller, J. Lemmer
doaj +1 more source
Microorganisms, 2021 Background: Periodontitis is a chronic inflammatory disease associated with a dysbiotic biofilm. Many pathogens have been related with its progression and severity, one of which is Aggregatibacter actinomycetemcomitans, a Gram-negative bacteria with ...
Daniel Betancur +2 more
doaj +1 more source
Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion [PDF]
, 2018 The altered isoform switching of the fibroblast growth factor receptor 2 (FGFR2) and aberrant expression of the mesenchymal FGFR2c isoform in epithelial cells is involved in cancer progression.
Anacker +43 more
core +1 more source
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation
Nature Communications, 2018 The chronic skin inflammation psoriasis is crucially dependent on the IL-23/IL-17 cytokine axis. Although IL-23 is expressed by psoriatic keratinocytes and immune cells, only the immune cell-derived IL-23 is believed to be disease relevant. Here we use a
Hui Li +17 more
semanticscholar +1 more source