Results 1 to 10 of about 94,650 (353)

Factors Determining Kinesin Motors in a Predominant One-Head-Bound or Two-Heads-Bound State During Its Stepping Cycle [PDF]

Biomolecules
At physiological or saturating ATP concentrations, some families of kinesin motors, such as kinesin-1 and kinesin-2, exhibit a predominant two-heads-bound (2HB) state during their stepping cycle on microtubules, while others, such as kinesin-3, exhibit a
Xiao-Xuan Shi, Yu-Ru Liu, Ping Xie
doaj   +2 more sources

A mutual co-recognition mechanism ensures the proper assembly of heterotrimeric kinesin-2 for intraflagellar transport [PDF]

Nature Communications
Heterotrimeric kinesin-2, composed of two distinct kinesin motors and a kinesin-associated protein (KAP), is essential for intraflagellar transport and ciliogenesis.
Jinqi Ren, Lingyan Zhao, Guanghan Chen, Guangshuo Ou, Wei Feng   +4 more
doaj   +2 more sources

Inward transport of organelles drives outward migration of the spindle during C. elegans meiosis [PDF]

Cell Reports
Summary: Cortical positioning of the meiotic spindle within an oocyte is required to expel chromosomes into polar bodies to generate a zygote with the correct number of chromosomes. In C.
Alma P. Aquino, Wenzhe Li, Aastha Lele, Denisa Lazureanu, Megan F. Hampton, Rebecca M. Do, Melissa C. Lafrades, Maria G. Barajas, Antonio A. Batres, Francis J. McNally   +9 more
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Autoinhibited kinesin-1 adopts a hierarchical folding pattern

eLife, 2023
Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 ...
Zhenyu Tan, Yang Yue, Felipe Leprevost, Sarah Haynes, Venkatesha Basrur, Alexey I Nesvizhskii, Kristen J Verhey, Michael A Cianfrocco   +7 more
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A synthetic ancestral kinesin-13 depolymerizes microtubules faster than any natural depolymerizing kinesin

Open Biology, 2022
The activity of a kinesin is largely determined by the approximately 350 residue motor domain, and this region alone is sufficient to classify a kinesin as a member of a particular family.
Hannah R. Belsham, Hanan M. Alghamdi, Nikita Dave, Alexandra J. Rathbone, Bill Wickstead, Claire T. Friel   +5 more
doaj   +1 more source

An essential farnesylated kinesin in Trypanosoma brucei. [PDF]

PLoS ONE, 2011
Kinesins are a family of motor proteins conserved throughout eukaryotes. In our present study we characterize a novel kinesin, Kinesin(CaaX), orthologs of which are only found in the kinetoplastids and not other eukaryotes.
Erin J Engelson, Frederick S Buckner, Wesley C Van Voorhis   +2 more
doaj   +1 more source

Effect of the Neck Linker on Processive Stepping of Kinesin Motor

Biophysica, 2023
Kinesin motor protein, which is composed of two catalytic domains connected together by a long coiled-coil stalk via two flexible neck linkers (NLs), can step processively on a microtubule towards the plus end by hydrolyzing adenosine triphosphate (ATP ...
Ping Xie
doaj   +1 more source

Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

eLife, 2022
Bidirectional cargo transport in neurons requires competing activity of motors from the kinesin-1, -2, and -3 superfamilies against cytoplasmic dynein-1.
Allison M Gicking, Tzu-Chen Ma, Qingzhou Feng, Rui Jiang, Somayesadat Badieyan, Michael A Cianfrocco, William O Hancock   +6 more
doaj   +1 more source

Anchoring geometry is a significant factor in determining the direction of kinesin-14 motility on microtubules

Scientific Reports, 2022
Kinesin-14 microtubule-based motors have an N-terminal tail attaching the catalytic core to its load and usually move towards microtubule minus ends, whilst most other kinesins have a C-terminal tail and move towards plus ends.
Masahiko Yamagishi, Rieko Sumiyoshi, Douglas R. Drummond, Junichiro Yajima   +3 more
doaj   +1 more source

Recycling of kinesin-1 motors by diffusion after transport. [PDF]

PLoS ONE, 2013
Kinesin motors drive the long-distance anterograde transport of cellular components along microtubule tracks. Kinesin-dependent transport plays a critical role in neurogenesis and neuronal function due to the large distance separating the soma and nerve ...
T Lynne Blasius, Nathan Reed, Boris M Slepchenko, Kristen J Verhey   +3 more
doaj   +1 more source