Results 1 to 10 of about 44,263 (215)
The mechanism of kinesin inhibition by kinesin-binding protein [PDF]
eLife, 2020 Subcellular compartmentalisation is necessary for eukaryotic cell function. Spatial and temporal regulation of kinesin activity is essential for building these local environments via control of intracellular cargo distribution.
Joseph Atherton +8 more
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Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments [PDF]
Nature Communications, 2020 Intracellular trafficking of organelles is driven by kinesin-1 stepping along microtubules, but crowding conditions impede kinesin-1 motility. Here authors demonstrate that TRAK1, an adaptor protein essential for mitochondrial trafficking, activates ...
Verena Henrichs +8 more
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Factors Determining Kinesin Motors in a Predominant One-Head-Bound or Two-Heads-Bound State During Its Stepping Cycle [PDF]
BiomoleculesAt physiological or saturating ATP concentrations, some families of kinesin motors, such as kinesin-1 and kinesin-2, exhibit a predominant two-heads-bound (2HB) state during their stepping cycle on microtubules, while others, such as kinesin-3, exhibit a
Xiao-Xuan Shi, Yu-Ru Liu, Ping Xie
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A mutual co-recognition mechanism ensures the proper assembly of heterotrimeric kinesin-2 for intraflagellar transport [PDF]
Nature CommunicationsHeterotrimeric kinesin-2, composed of two distinct kinesin motors and a kinesin-associated protein (KAP), is essential for intraflagellar transport and ciliogenesis.
Jinqi Ren +4 more
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Autoinhibited kinesin-1 adopts a hierarchical folding pattern
eLife, 2023 Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 ...
Zhenyu Tan +7 more
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Open Biology, 2022 The activity of a kinesin is largely determined by the approximately 350 residue motor domain, and this region alone is sufficient to classify a kinesin as a member of a particular family.
Hannah R. Belsham +5 more
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Effect of the Neck Linker on Processive Stepping of Kinesin Motor
Biophysica, 2023 Kinesin motor protein, which is composed of two catalytic domains connected together by a long coiled-coil stalk via two flexible neck linkers (NLs), can step processively on a microtubule towards the plus end by hydrolyzing adenosine triphosphate (ATP ...
Ping Xie
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An essential farnesylated kinesin in Trypanosoma brucei. [PDF]
PLoS ONE, 2011 Kinesins are a family of motor proteins conserved throughout eukaryotes. In our present study we characterize a novel kinesin, Kinesin(CaaX), orthologs of which are only found in the kinetoplastids and not other eukaryotes.
Erin J Engelson +2 more
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Kinesin transport: driving kinesin in the neuron [PDF]
Current Biology, 2001 A plethora of cytoplasmic motors contribute to the directed transport of a wide range of cellular organelles and molecules. Recent studies have advanced our understanding of cargo attachment to motor molecules and the regulation of intracellular transport.
Hays, Tom, Li, Min-gang
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Scientific Reports, 2022 Kinesin-14 microtubule-based motors have an N-terminal tail attaching the catalytic core to its load and usually move towards microtubule minus ends, whilst most other kinesins have a C-terminal tail and move towards plus ends.
Masahiko Yamagishi +3 more
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