Results 111 to 120 of about 94,650 (353)

Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish [PDF]

, 2016
Photoreceptors are highly specialized sensory neurons that possess a modified primary cilium called the outer segment. Photoreceptor outer segment formation and maintenance require highly active protein transport via a process known as intraflagellar ...
Akhtar, Alfinito, Avasthi, Bachmann-Gagescu, Baker, Beech, Brockerhoff, Cao, Deacon, Eblimit, Goetz, Huang, Insinna, Insinna, Insinna, Jiang, Jimeno, Jimeno, Kodani, Krock, Lopes, Louie, Makhankov, Marszalek, Marszalek, Muresan, Muresan, Nascimento, Nonaka, Pazour, Ryan, Scholey, Shu, Stearns, Sukumaran, Traverso, Trivedi, Tsujikawa, Tuma, Westerfield, Whitehead, Wolfrum, Yamazaki, Yang, Zhao   +44 more
core   +2 more sources

Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells

BioEssays, EarlyView.
Primary cilia are developmentally essential subcellular signaling compartments. However, many differentiated cells lack primary cilia, and cilia disassembly in these tissue contexts has been largely overlooked. We highlight several pathways for primary cilia loss and examine how changes in ciliation states could contribute to diverse pathologies ...
Carolyn M. Ott, Saikat Mukhopadhyay
wiley   +1 more source

Dynein catch bond as a mediator of codependent bidirectional cellular transport

, 2019
Intracellular bidirectional transport of cargo on microtubule filaments is achieved by the collective action of oppositely directed dynein and kinesin motors.
Chandel, Sameep, Chaudhuri, Abhishek, Gupta, Nisha, Mitra, Mithun K., Muhuri, Sudipto, Nair, Anil, Naskar, Supriyo, Puri, Palka   +7 more
core   +1 more source

When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination

BioEssays, EarlyView.
Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Cornelia Sala, Elmar Schiebel
wiley   +1 more source

Transport by molecular motors in the presence of static defects [PDF]

, 2009
The transport by molecular motors along cytoskeletal filaments is studied theoretically in the presence of static defects. The movements of single motors are described as biased random walks along the filament as well as binding to and unbinding from the
A. Ebneth, A. Parmeggiani, A. Seitz, A. Seitz, A.B. Kolomeisky, B. Schmittmann, B.M. Paschal, C. Leduc, E.-M. Mandelkow, G. Tripathy, G.A. Klein, G.M. Schütz, H. Hagiwara, H. Hess, I.M. Crevel, J. Beeg, J. Howard, J. Krug, J.-C. Larcher, J.C. Bulisnki, K. Nishinari, K. Tokuraku, L.A. Lopez, L.J. Davis, L.S.B. Goldstein, M. Vershinin, M. Vershinin, M.G.L. Heuvel Van den, M.J.I. Müller, M.J.I. Müller, M.R. Evans, N. Mirin, N.A. Reed, P. Pierobon, R. Dixit, R. Lipowsky, R. Lipowsky, R. Sato-Harada, Reinhard Lipowsky, S. Heins, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Klumpp, S. Konzack, S. Lakämper, S.A. Janowsky, Stefan Klumpp, T.M. Nieuwenhuizen, Yan Chai   +52 more
core   +3 more sources

Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation

Biomolecules, 2018
Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation.
Sanjay Shrestha, Mark A. Hazelbaker, Amber L. Yount, C. Walczak   +3 more
semanticscholar   +1 more source

Kinesin's second step [PDF]

Proceedings of the National Academy of Sciences, 2004
We have identified dimeric kinesin mutants that become stalled on the microtubule after one ATP turnover, unable to bind and hydrolyze ATP at their second site. We have used these mutants to determine the regulatory signal that allows ATP to bind to the forward head, such that processive movement can continue.
Susan P. Gilbert, Andreas Hoenger, Lisa M. Klumpp   +2 more
openaire   +3 more sources

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

Cytoskeleton, EarlyView.
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley   +1 more source

Oncogenic role of kinesin proteins and targeting kinesin therapy

Cancer Science, 2013
The kinesin superfamily (KIF) is a group of proteins that share a highly conserved motor domain. Except for some members, many KIF proteins have adenosine triphosphatase activity and microtubule‐dependent plus‐end motion ability. Kinesins participate in several essential cellular functions, including mitosis, meiosis and the transport of macromolecules.
Hao Gong, Kun Huang, Xinran Liu
openaire   +3 more sources

Interaction Between Actin and Microtubules During Plant Development

Cytoskeleton, EarlyView.
ABSTRACT The dynamic interaction between actin filaments (AFs) and microtubules (MTs) plays a crucial role in regulating key developmental and physiological processes in plant cells, particularly in the formation of specialized cell types with distinct shapes and functions, such as pollen tubes, trichomes, and leaf epidermal cells.
Zining Wu, Lidong Gao, M. Arif Ashraf, Qiong Nan   +3 more
wiley   +1 more source