Results 11 to 20 of about 94,650 (353)
The functions of kinesin and kinesin-related proteins in eukaryotes [PDF]
Cell Adhesion & Migration, 2020 Kinesins constitute a superfamily of ATP-driven microtubule motor enzymes that convert the chemical energy of ATP hydrolysis into mechanical work along microtubule tracks. Kinesins are found in all eukaryotic organisms and are essential to all eukaryotic
Iftikhar Ali, Wei-cai Yang
semanticscholar +5 more sources
The mechanism of kinesin inhibition by kinesin-binding protein [PDF]
eLife, 2020 Subcellular compartmentalisation is necessary for eukaryotic cell function. Spatial and temporal regulation of kinesin activity is essential for building these local environments via control of intracellular cargo distribution.
Joseph Atherton +8 more
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Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments
Nature Communications, 2020 Intracellular trafficking of organelles is driven by kinesin-1 stepping along microtubules, but crowding conditions impede kinesin-1 motility. Here authors demonstrate that TRAK1, an adaptor protein essential for mitochondrial trafficking, activates ...
Verena Henrichs +8 more
doaj +2 more sources
PLoS Pathogens, 2019 Kinesin-8 proteins are microtubule motors that are often involved in regulation of mitotic spindle length and chromosome alignment. They move towards the plus ends of spindle microtubules and regulate the dynamics of these ends due, at least in some ...
Mohammad Zeeshan +17 more
doaj +2 more sources
Kinesin-5 inhibitor resistance is driven by kinesin-12 [PDF]
Journal of Cell Biology, 2016 The kinesin-5 Eg5 is essential for mitotic progression, and the lethal effects of Eg5 inhibitors make these inhibitors attractive candidates for chemotherapy drugs. Sturgill et al.
Emma G. Sturgill +3 more
semanticscholar +4 more sources
MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport. [PDF]
eLife, 2018 Neuronal cell morphogenesis depends on proper regulation of microtubule-based transport, but the underlying mechanisms are not well understood.
Ma, Le +3 more
core +3 more sources
Nature Communications, 2017 Bipolar spindle assembly requires a balance of kinesin 14 pulling and kinesin 5 pushing forces. Here, the authors show that in fission yeast, spindle formation can occur in the absence of kinesin 5 (Cut7) and 14 (Pkl1) but requires the microtubule ...
Sergio A. Rincon +7 more
doaj +2 more sources
Nature Communications, 2023 Mitochondrial transport along microtubules is mediated by Miro1 and TRAK adaptors that recruit kinesin-1 and dynein-dynactin. To understand how these opposing motors are regulated during mitochondrial transport, we reconstitute the bidirectional ...
J. Canty +4 more
semanticscholar +1 more source
MINFLUX dissects the unimpeded walking of kinesin-1
bioRxiv, 2022 We report on an interferometric MINFLUX microscope that records protein movements with down to 1.7 nm precision within less than 1 ms. While such spatio-temporal resolution has so far required linking a strongly scattering 30-500 nm diameter bead to the ...
Jan O. Wolff +5 more
semanticscholar +1 more source
Nature, 1996 Chromosome segregation during mitosis depends on the action of the mitotic spindle, a self-organizing, bipolar protein machine which uses microtubules (MTs) and their associated motors. Members of the BimC subfamily of kinesin-related MT-motor proteins are believed to be essential for the formation and functioning of a normal bipolar spindle.
A. S. Kashlna +5 more
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