Results 21 to 30 of about 94,650 (353)
Science, 2022 Microtubule (MT)–associated protein 7 (MAP7) is a required cofactor for kinesin-1–driven transport of intracellular cargoes. Using cryo–electron microscopy and single–molecule imaging, we investigated how MAP7 binds MTs and facilitates kinesin-1 motility.
Luke S. Ferro +12 more
semanticscholar +1 more source
Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors
Nature Communications, 2021 Mitochondria are transported along microtubules by opposing kinesin and dynein motors. Kinesin-1 and dynein-dynactin are linked to mitochondria by TRAK proteins, but it is unclear how TRAKs coordinate these motors. We used single-molecule imaging of cell
Adam R. Fenton, T. Jongens, E. Holzbaur
semanticscholar +1 more source
Kinesin transport: driving kinesin in the neuron [PDF]
Current Biology, 2001 A plethora of cytoplasmic motors contribute to the directed transport of a wide range of cellular organelles and molecules. Recent studies have advanced our understanding of cargo attachment to motor molecules and the regulation of intracellular transport.
Mingang Li, Thomas S. Hays
openaire +3 more sources
Journal of Cell Science, 2010 Kinesin was discovered in 1985 – 25 years ago – based on its motility in cytoplasm extruded from the giant axon of the squid ([Allen et al., 1982][1]; [Brady et al., 1982][2]; [Vale et al., 1985][3]).
Endow, Sharyn A +2 more
openaire +4 more sources
Kinesins in spermatogenesis† [PDF]
Biology of Reproduction, 2017 Kinesins are essential for the proper function of many types of polar cells, including epithelial cells, neurons, and sperm. Spermatogenesis is closely associated with many different kinesins. These kinesins participate in several fundamental processes, including mitotic and meiotic division, essential organelle transport, and the biogenesis of ...
Wan-Xi Yang, Da-Hui Wang, Dan-Dan Ma
openaire +3 more sources
Germanium nanospheres for ultraresolution picotensiometry of kinesin motors
Science, 2020 Kinesin takes substeps Simultaneously measuring the nanoscale motion and forces that molecular machines generate provides insights into how they work mechanically to fulfill their cellular function. To study these machines, Sudhakar et al.
S. Sudhakar +5 more
semanticscholar +1 more source
Electrostatically biased binding of kinesin to microtubules. [PDF]
PLoS Biology, 2011 The minimum motor domain of kinesin-1 is a single head. Recent evidence suggests that such minimal motor domains generate force by a biased binding mechanism, in which they preferentially select binding sites on the microtubule that lie ahead in the ...
Barry J Grant +7 more
doaj +1 more source
bioRxiv, 2020 The kinesin-3 motor KIF1A functions in neurons where its fast and superprocessive motility is thought to be critical for long-distance transport. However, little is known about the force-generating properties of kinesin-3 motors.
B. Budaitis +5 more
semanticscholar +1 more source
Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family [PDF]
, 2014 Kinesins are responsible for a wide variety of microtubule-based, ATP-dependent functions. Their motor domain drives these activities but the molecular adaptations that specify these diverse and essential cellular activities are poorly understood.
Goulet, Adeline +5 more
core +2 more sources
Kinesin Light Chains Are Essential for Axonal Transport in Drosophila [PDF]
, 1998 Kinesin is a heterotetramer composed of two 115-kD heavy chains and two 58-kD light chains. The microtubule motor activity of kinesin is performed by the heavy chains, but the functions of the light chains are poorly understood.
Beushausen, Sven +4 more
core +2 more sources