Results 41 to 50 of about 94,650 (353)

Cytoskeleton: A catastrophic kinesin [PDF]

Current Biology, 1996
The 'plus' ends of microtubules exhibit dynamic instability, switching stochastically from growth to shortening phases. The first endogenous regulator of such 'catastrophes' has been identified, and is a kinesin-related microtubule motor protein.
Edward D. Salmon, Jennifer C. Waters
openaire   +3 more sources

Prime movers : mechanochemistry of mitotic kinesins [PDF]

, 2014
Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams.
A Blangy, A Groen, A Hutterer, A Jannasch, A Karabay, A Toso, A Yildiz, AA Levesque, AB Asenjo, AC Groen, AE Butterfield, AF Huxley, AF Straight, AJ Roberts, AM Mulder, AM Saunders, Andrew McAinsh, AS Kashina, AS Khalil, B Gigant, B Owens, B Wickstead, BH Kwok, BH Kwok, BJ Grant, BT Schaar, C Antonio, C Hentrich, C Peters, C Thiede, C Wandke, CA Watts, CC Leduc, CE Walczak, CJ Lawrence, CK Hu, CL Parke, CL Rieder, CL Rieder, CM Whitehead, CTC Friel, CV Sindelar, CV Sindelar, D Vanneste, D Vanneste, DA Compton, E Doménech, E Karsenti, E Vladimirou, EG Sturgill, ER Hildebrandt, FJ Kull, FJ Kull, G Fink, GC Rogers, GJ Brouhard, GJ Gorbsky, GJPL Kops, H Aizawa, H Boleti, H Drechsler, H Funabiki, H Yardimci, HS Sardar, HS Sardar, HYK Kaan, I Brust-Mascher, I Brust-Mascher, I Minoura, IM Crevel, IM-TC Crevel, J Espeut, J Helenius, J Roostalu, J Roostalu, J Rosenblatt, J Stumpff, J Stumpff, J Stumpff, J Yajima, JC Cochran, JC Gatlin, JC Waters, JM Scholey, JPI Welburn, JR Aist, JR Cooper, JR McIntosh, JRJ Stout, JS Allingham, JS Weinger, K Hahlen, K Jaqaman, K Kaseda, K Kaseda, K Samejima, KE Gascoigne, KJ Verhey, KS Burbank, KW Wood, KW Wood, KY Lee, L Wordeman, LC Kapitein, LC Kapitein, LN Weaver, LR Sproul, M Braun, M Braun, M Glotzer, M Joshi, M Kikkawa, M Klejnot, M Mishima, M Nishiyama, M Wagenbach, MA Hoyt, MA Seeger, MC Alonso, ME Douglas, ME Tanenbaum, ME Tanenbaum, ME Tanenbaum, MI Mayr, MJ Korneev, ML Gupta, MT Valentine, MT Valentine, N Gudimchuk, N Hirokawa, N Hirokawa, N Joseph, NF Endres, NJ Carter, NJ Ganem, OO Rath, P Bieling, Q Chang, R Nitta, R Nunes Bastos, R Uehara, RB Case, RD Vale, Robert A. Cross, S Acar, S Cai, S Cane, S Debonis, S Diez, S Dumont, S Highsmith, S Inoué, S Oh, S Rice, S Rice, S Shastry, SF Bakhoum, SS Rosenfeld, SS Rosenfeld, SW Grill, T Krzysiak, T Maney, T Surrey, TJ Mitchison, TJ Mitchison, TM Kapoor, TT Ogawa, V Fridman, V Magidson, V Mountain, V Varga, VV Bormuth, W Saunders, WW Wang, X Su, X Su, Y Du, Y Kim, Y Kurasawa, Y Oguchi, Y Zhai, YF Dufrene, YM Lee, YY Okada, Z Yang   +184 more
core   +1 more source

Kinetically distinct phases of tau on microtubules regulate kinesin motors and severing enzymes

Nature Cell Biology, 2018
Tau is an intrinsically disordered protein, which diffuses on microtubules1. In neurodegenerative diseases, collectively termed tauopathies, malfunction of tau and its detachment from axonal microtubules are correlated with axonal degeneration2.
Valerie Siahaan, J. Krattenmacher, A. Hyman, S. Diez, Amayra Hernández-Vega, Z. Lánský, Marcus Braun   +6 more
semanticscholar   +1 more source

MAP7 family proteins regulate kinesin-1 recruitment and activation

bioRxiv, 2018
Kinesin-1 is responsible for microtubule-based transport of numerous cellular cargoes. Here, we explored the regulation of kinesin-1 by MAP7 proteins. We found that all four mammalian MAP7 family members bind to kinesin-1. In HeLa cells, MAP7, MAP7D1 and
Peter Jan Hooikaas, Maud Martin, Tobias Mühlethaler, Gert-Jan Kuijntjes, C. A. Peeters, E. Katrukha, Luca Ferrari, Riccardo Stucchi, Daan G F Verhagen, W. V. van Riel, I. Grigoriev, A. M. Altelaar, C. Hoogenraad, S. Rüdiger, M. Steinmetz, L. Kapitein, A. Akhmanova   +16 more
semanticscholar   +1 more source

A standardized kinesin nomenclature [PDF]

The Journal of Cell Biology, 2004
In recent years the kinesin superfamily has become so large that several different naming schemes have emerged, leading to confusion and miscommunication. Here, we set forth a standardized kinesin nomenclature based on 14 family designations. The scheme unifies all previous phylogenies and nomenclature proposals, while allowing individual sequence ...
Lawrence, Carolyn J, Dawe, R Kelly, Christie, Karen R, Cleveland, Don W, Dawson, Scott C, Endow, Sharyn A, Goldstein, Lawrence SB, Goodson, Holly V, Hirokawa, Nobutaka, Howard, Jonathon, Malmberg, Russell L, McIntosh, J Richard, Miki, Harukata, Mitchison, Timothy J, Okada, Yasushi, Reddy, Anireddy SN, Saxton, William M, Schliwa, Manfred, Scholey, Jonathan M, Vale, Ronald D, Walczak, Claire E, Wordeman, Linda   +21 more
openaire   +5 more sources

Length-dependent disassembly maintains four different flagellar lengths in Giardia. [PDF]

, 2019
With eight flagella of four different lengths, the parasitic protist Giardia is an ideal model to evaluate flagellar assembly and length regulation. To determine how four different flagellar lengths are maintained, we used live-cell quantitative imaging ...
Aurrecoechea, Avidor-Reiss, Avidor-Reiss, Ball, Barker, Berman, Bertiaux, Blaineau, Bradley, Briggs, Brooks, Buchel, Buisson, Chan, Chien, Cole, Cooper, Coyne, Craft, Dawson, Deane, Desai, Ellenberg, Engel, Fai, Gibson, Gourguechon, Hagen, Hao, Hardin, Helenius, Hendel, Hilton, Hoeng, Hunter, Ishikawa, Kozminski, Lechtreck, Lenaghan, Ludington, Ludington, Mangeol, Manning, Marshall, Marshall, McInally, McInally, Meng, Mohapatra, Naoz, Nohynková, Pazour, Pazour, Piao, Reiter, Rosenbaum, Sagolla, Schindelin, Shaner, Sung, Tamm, Vasudevan, Walczak, Wang, Wei, Williams, Wingfield, Wloga, Woessner, Wren   +69 more
core   +2 more sources

Mitotic Kinesins: A Reason to Delve into Kinesin-12 [PDF]

Current Biology, 2014
The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to explain its targeting to kinetochore fibers and its ability to compensate for inhibition of kinesin-5.
openaire   +3 more sources

Heterogeneity in kinesin function [PDF]

Traffic, 2017
The kinesin family proteins are often studied as prototypical molecular motors; a deeper understanding of them can illuminate regulation of intracellular transport. It is typically assumed that they function identically. Here we find that this assumption of homogeneous function appears incorrect: variation among motors’ velocities in vivo and in vitro ...
Steven P. Gross, Babu J.N. Reddy, Marvin E. Tanenbaum, Changbong Hyeon, Jing Xu, Karim Arabi, Michael Vershinin, Suvranta K. Tripathy, Suvranta K. Tripathy, Michelle K. Mattson-Hoss, Dail Chapman, Tory Doolin   +11 more
openaire   +4 more sources

Characterization of Motility Properties of Kinesin-Driven Microtubules Towards Nano-Scale Transporter: Focusing on Length of Microtubules and Kinesin Density

Journal of Biomechanical Science and Engineering, 2008
Kinesins, biomolecular motors moving along microtubules (MTs) in cells, can potentially be utilized as nano-scale transport systems with an inverted gliding assay, in which the MTs glide on a kinesin-coated surface.
Shukei SUGITA, Naoya SAKAMOTO, Toshiro OHASHI, Masaaki SATO   +3 more
doaj   +1 more source

Kinesin's backsteps under mechanical load [PDF]

, 2009
Kinesins move processively toward the plus end of microtubules by hydrolyzing ATP for each step. From an enzymatic perspective, the mechanism of mechanical motion coupled to the nucleotide chemistry is often well explained using a single-loop cyclic ...
Alberty, Alonso, Asbury, Baker, Beeg, Bell, Block, Block, Block, Brady, Brant, Carter, Changbong Hyeon, Chemla, Coppin, Coppin, Cross, Cross, Fisher, Fisher, Gelles, Gilbert, Gross, Guydosh, Hackney, Hackney, Howard, Hunt, Hyeon, Hyeon, Itoh, José N. Onuchic, Kawaguchi, Klumpp, Kojima, Kolomeisky, Liepelt, Liphardt, Lipowsky, Ma, Meyhofer, Mickler, Mori, Moyer, Muller, Nishiyama, Nishiyama, Oster, Qian, Qu, Reimann, Rice, Rice, Ross, Russell, Schief, Schief, Schnitzer, Schnitzer, Stefan Klumpp, Svoboda, Taniguchi, Thirumalai, Tsygankov, Uemura, Uemura, Vale, Vale, Visscher, Wu, Yildiz, Yildiz   +71 more
core   +1 more source