Results 1 to 10 of about 29,043 (290)

Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins [PDF]

Cell Death and Disease
Cilia are highly conserved eukaryotic organelles that protrude from the cell surface and are involved in sensory perception, motility, and signaling.
Lin Li, Jie Ran
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Double Duty: Mitotic Kinesins and Their Post-Mitotic Functions in Neurons

Cells, 2021
Neurons, regarded as post-mitotic cells, are characterized by their extensive dendritic and axonal arborization. This unique architecture imposes challenges to how to supply materials required at distal neuronal components.
Nadine F. Joseph, Supriya Swarnkar, Sathyanarayanan V Puthanveettil   +2 more
doaj   +2 more sources

Genome-wide functional analysis reveals key roles for kinesins in the mammalian and mosquito stages of the malaria parasite life cycle.

PLoS Biology, 2022
Kinesins are microtubule (MT)-based motors important in cell division, motility, polarity, and intracellular transport in many eukaryotes. However, they are poorly studied in the divergent eukaryotic pathogens Plasmodium spp., the causative agents of ...
Mohammad Zeeshan, Ravish Rashpa, David J P Ferguson, Steven Abel, Zeinab Chahine, Declan Brady, Sue Vaughan, Carolyn A Moores, Karine G Le Roch, Mathieu Brochet, Anthony A Holder, Rita Tewari   +11 more
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Phosphoregulation of Kinesins Involved in Long-Range Intracellular Transport

Frontiers in Cell and Developmental Biology, 2022
Kinesins, the microtubule-dependent mechanochemical enzymes, power a variety of intracellular movements. Regulation of Kinesin activity and Kinesin-Cargo interactions determine the direction, timing and flux of various intracellular transports.
Diksha Kumari, Krishanu Ray
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Multiple kinesins induce tension for smooth cargo transport

eLife, 2019
How cargoes move within a crowded cell—over long distances and at speeds nearly the same as when moving on unimpeded pathway—has long been mysterious.
Marco Tjioe, Saurabh Shukla, Rohit Vaidya, Alice Troitskaia, Carol S Bookwalter, Kathleen M Trybus, Yann R Chemla, Paul R Selvin   +7 more
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Kinesins in Mammalian Spermatogenesis and Germ Cell Transport

Frontiers in Cell and Developmental Biology, 2022
In mammalian testes, the apical cytoplasm of each Sertoli cell holds up to several dozens of germ cells, especially spermatids that are transported up and down the seminiferous epithelium. The blood-testis barrier (BTB) established by neighboring Sertoli
Mingxia Yao, Haoyang Qu, Yating Han, C. Yan Cheng, Xiang Xiao, Xiang Xiao   +5 more
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Concerted action of kinesins KIF5B and KIF13B promotes efficient secretory vesicle transport to microtubule plus ends

eLife, 2020
Intracellular transport relies on multiple kinesins, but it is poorly understood which kinesins are present on particular cargos, what their contributions are and whether they act simultaneously on the same cargo.
Andrea Serra-Marques, Maud Martin, Eugene A Katrukha, Ilya Grigoriev, Cathelijn AE Peeters, Qingyang Liu, Peter Jan Hooikaas, Yao Yao, Veronika Solianova, Ihor Smal, Lotte B Pedersen, Erik Meijering, Lukas C Kapitein, Anna Akhmanova   +13 more
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Highly loaded behavior of kinesins increases the robustness of transport under high resisting loads.

PLoS Computational Biology, 2015
Kinesins are nano-sized biological motors which walk by repeating a mechanochemical cycle. A single kinesin molecule is able to transport its cargo about 1 μm in the absence of external loads.
Woochul Nam, Bogdan I Epureanu
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The cooperative roles of two kinetoplastid-specific kinesins in cytokinesis and in maintaining cell morphology in bloodstream trypanosomes. [PDF]

PLoS ONE, 2013
The cytoskeleton of Trypanosoma brucei, a unicellular eukaryote and a parasitic protozoan, is defined by the subpellicular microtubule corset that is arranged underneath the plasma membrane. We recently identified two orphan kinesins, TbKIN-C and TbKIN-D,
Ying Wei, Huiqing Hu, Zhao-Rong Lun, Ziyin Li   +3 more
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Total Internal Reflection Fluorescence (TIRF) Single-Molecule Assay to Analyze the Motility of Kinesin [PDF]

Bio-Protocol
The motile parameters of kinesin superfamily proteins are fundamental to intracellular transport. Single-molecule motility assays using total internal reflection fluorescence (TIRF) microscopy are a gold standard technique for measuring the motile ...
Tomoki Kita, Shinsuke Niwa
doaj   +2 more sources