Results 1 to 10 of about 23,162 (298)
Kinesins in Caenorhabditis elegans neuronal morphogenesis [PDF]
Open BiologyNeuronal morphogenesis is regulated by intracellular transport and cytoskeletal dynamics. Kinesin superfamily proteins (KIFs), or kinesins, function as molecular motors for intracellular transport and as regulators of the microtubule cytoskeleton, making
Shinsuke Niwa, Kyoko Chiba
doaj +2 more sources
Total Internal Reflection Fluorescence (TIRF) Single-Molecule Assay to Analyze the Motility of Kinesin [PDF]
Bio-ProtocolThe motile parameters of kinesin superfamily proteins are fundamental to intracellular transport. Single-molecule motility assays using total internal reflection fluorescence (TIRF) microscopy are a gold standard technique for measuring the motile ...
Tomoki Kita, Shinsuke Niwa
doaj +2 more sources
Regulation of ciliary homeostasis by intraflagellar transport-independent kinesins [PDF]
Cell Death and DiseaseCilia are highly conserved eukaryotic organelles that protrude from the cell surface and are involved in sensory perception, motility, and signaling.
Lin Li, Jie Ran
doaj +2 more sources
HPV16 entry requires dynein for minus-end transport and utilizes kinesin Kif11 for plus-end transport along microtubules during mitosis [PDF]
Journal of VirologyHuman papillomaviruses (HPVs) travel from the trans-Golgi network (TGN) to the condensed (mitotic) chromosomes during mitosis. Partially uncoated HPV capsids utilize a unique vesicular structure for trafficking and nuclear import, which is directed by ...
Timothy R. Keiffer +7 more
doaj +2 more sources
Molecular Motors in Blood–Brain Barrier Maintenance by Astrocytes [PDF]
Brain SciencesThe blood–brain barrier (BBB) comprises distinct cell types, including endothelial cells, pericytes, and astrocytes, and is essential for central nervous system (CNS) homeostasis by selectively regulating molecular transport and maintaining integrity. In
Ana Filipa Sobral +4 more
doaj +2 more sources
Double Duty: Mitotic Kinesins and Their Post-Mitotic Functions in Neurons
Cells, 2021 Neurons, regarded as post-mitotic cells, are characterized by their extensive dendritic and axonal arborization. This unique architecture imposes challenges to how to supply materials required at distal neuronal components.
Nadine F. Joseph +2 more
doaj +1 more source
An Unveiled Cell Death Mechanism Exclusive to Human Cancer Cells
Biology and Life Sciences Forum, 2023 The modified phenanthridine PJ34 blocks the post-translational modifications of specific proteins highly expressed in human malignant cells. This exclusively arrests mitosis in human malignant cells by inserting flaws in their mitotic spindle structure ...
Malka Cohen-Armon
doaj +1 more source
Axonal transport during injury on a theoretical axon
Frontiers in Cellular Neuroscience, 2023 Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles.
Soumyadeep Chandra +6 more
doaj +1 more source
Scientific Reports, 2023 Lung cancer is the leading cause of mortality from cancer worldwide. Lung adenocarcinoma (LUAD) is a type of non-small cell lung cancer (NSCLC) with highest prevalence. Kinesins a class of motor proteins are shown to be involved in carcinogenesis.
Gulnaz Tabassum +11 more
doaj +1 more source
Comprehensive comparative analysis of kinesins in photosynthetic eukaryotes
BMC Genomics, 2006 Background Kinesins, a superfamily of molecular motors, use microtubules as tracks and transport diverse cellular cargoes. All kinesins contain a highly conserved ~350 amino acid motor domain.
Reddy Anireddy SN +2 more
doaj +1 more source