Results 91 to 100 of about 23,162 (298)

Motor proteins traffic regulation by supply-demand balance of resources

, 2014
In cells and in vitro assays the number of motor proteins involved in biological transport processes is far from being unlimited. The cytoskeletal binding sites are in contact with the same finite reservoir of motors (either the cytosol or the flow ...
Ciandrini, Luca, Dauloudet, O., Neri, I., Parmeggiani, A., Walter, Jean-Charles   +4 more
core   +3 more sources

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Kinesins relocalize the chromosomal passenger complex to the midzone for spindle disassembly. [PDF]

, 2018
Mitotic spindle disassembly after chromosome separation is as important as spindle assembly, yet the molecular mechanisms for spindle disassembly are unclear.
Avunie-Masala, Buvelot, Cheeseman, Chen, Cleary, Cormier, Cottingham, David G. Drubin, Foiani, Fridman, Georjana Barnes, Gruneberg, Hoyt, Hoyt, Hsu, Itziar Ibarlucea-Benitez, Jaqaman, Kang, Khmelinskii, Kotwaliwale, Longtine, Luke S. Ferro, Morawska, Movshovich, Murata-Hori, Nakajima, Nakajima, Nicholas, Nishimura, Norden, Petersen, Reck-Peterson, Saunders, Saunders, Shannon, Straight, Tarantino, Thomas, Varga, Woodruff, Woodruff, Xing, Zhang, Zimniak   +43 more
core   +1 more source

Integrative genomic analysis identifies associations of molecular alterations to APOBEC and BRCA1/2 mutational signatures in breast cancer

Molecular Genetics & Genomic Medicine, 2019
Background The observed mutations in cancer are the result of ~30 mutational processes, which stamp particular mutational signatures (MS). Nevertheless, it is still not clear which genomic alterations correlate to several MS.
Victor Trevino
doaj   +1 more source

Physics of Transport and Traffic Phenomena in Biology: from molecular motors and cells to organisms

, 2005
Traffic-like collective movements are observed at almost all levels of biological systems. Molecular motor proteins like, for example, kinesin and dynein, which are the vehicles of almost all intra-cellular transport in eukayotic cells, sometimes ...
Aghababaie, Anderson, Anderson, Anderson, Anderson, Anderson, Andreas Schadschneider, Antal, Aridor, Aridor, Arndt, Arndt, Astumian, Bonabeau, Bonabeau, Bonabeau, Bonabeau, Bonabeau, Burd, Burd, Burstedde, Camazine, Chopard, Chopard, Chou, Chowdhury, Chowdhury, Chowdhury, Coffey, Couzin, de Gier, Debashish Chowdhury, Derenyi, Derenyi, Derrida, Derrida, Derrida, Dorigo, Ebneth, Edelstein-Keshet, Evans, Evans, Evans, Evans, Evans, Feynman, Fisher, Frey, Fukui, Gautrais, Gipps, Goldstein, Goldstein, Goldstein, Goldstein, Goldstein, Grimm, Gross, Gueron, Hackney, Harms, Helbing, Helbing, Helbing, Helbing, Helbing, Helbing, Henderson, Hiratsuka, Hirokawa, Howard, Huang, Hughes, Hughes, Hölldobler, Jackson, Janowsky, John, Juhasz, Juhasz, Jülicher, Kafri, Katsuhiro Nishinari, Kirchner, Kirchner, Kirchner, Klein, Klumpp, Klumpp, Klumpp, Klumpp, Klüpfel, Kolomeisky, Krieger, Krug, Krug, Kruse, Ktitarev, Lakatos, Leduc, Lee, Lipowsky, Lipowsky, MacDonald, MacDonald, Mahnke, Mai, Mandelkow, Marchesoni, Marconi, Marro, Mikhailov, Mogilner, Mukherji, Muramatsu, Nagase, Nakayama, Nedlec, Nedlec, Nieuwenhuizen, Nieuwenhuizen, Nishinari, Nishinari, Nitta, O'Loan, O'Loan, Odell, Okada, Okada, Okada, Parmeggiani, Parmeggiani, Popescu, Popkov, Popkov, Popkov, Railsback, Rajewsky, Rajewsky, Ratnieks, Ratnieks, Rauch, Reimann, Risken, Saffarian, Sankararaman, Schadschneider, Schmittmann, Schweitzer, Schütz, Schütz, Shaw, Shaw, Shaw, Smoluchowski, Stamer, Surrey, Theraulaz, Theraulaz, Thompson, Tripathi, Watmough, Weibel, Welte, Whittaker, Wilson, Wolfram, Wolfram, Ziebert   +168 more
core   +1 more source

Length control of microtubules by depolymerizing motor proteins [PDF]

, 2008
In many intracellular processes, the length distribution of microtubules is controlled by depolymerizing motor proteins. Experiments have shown that, following non-specific binding to the surface of a microtubule, depolymerizers are transported to the ...
B. S. Govindan, D. Chowdhury, Hunter A. W., M. Gopalakrishnan   +3 more
core   +2 more sources

Post‐LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor

Cytoskeleton, EarlyView.
ABSTRACT Dyneins were present in the last eukaryotic common ancestor (LECA) and play key roles in eukaryotic biology. Axonemal dyneins form the inner and outer arms that power ciliary beating, and it has long been recognized that outer arms in some organisms contain two different heavy chain motors, whereas those from other species contain a third unit
Stephen M. King
wiley   +1 more source

Cooperative Cargo Transport by Several Molecular Motors

, 2005
The transport of cargo particles which are pulled by several molecular motors in a cooperative manner is studied theoretically. The transport properties depend primarily on the maximal number, $N$, of motor molecules that may pull simultaneously on the ...
Ashkin, Bell, Block, B  hm, Erdmann, Goldstein, Hill, Kuznetsov, Lipowsky, Miller, R. Lipowsky, S. Klumpp, Schnitzer, Seitz, Shah, Svoboda, Trinczek, Vale, Visscher, Wang   +19 more
core   +2 more sources

Directional instability of microtubule transport in the presence of kinesin and dynein, two opposite polarity motor proteins. [PDF]

, 1992
Kinesin and dynein are motor proteins that move in opposite directions along microtubules. In this study, we examine the consequences of having kinesin and dynein (ciliary outer arm or cytoplasmic) bound to glass surfaces interacting with the same ...
Brown, D, Malik, F, Vale, RD
core   +2 more sources