Results 51 to 60 of about 29,043 (290)
Traffic : the International Journal of Intracellular Transport, 2019 In mammals, 15 to 20 kinesins are thought to mediate vesicle transport. Little is known about the identity of vesicles moved by each kinesin or the functional significance of such diversity.
Rui Yang +5 more
semanticscholar +1 more source
The Journal of Cell Biology, 2007 When it is not actively transporting cargo, conventional Kinesin-1 is present in the cytoplasm in a folded conformation that cannot interact effectively with microtubules (MTs). Two important and largely unexplored aspects of kinesin regulation are how it is converted to an active species when bound to cargo and the related issue of how kinesin ...
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Kinesin regulation by Salmonella [PDF]
Virulence, 2011 As the result of their adaptation to the host, intracellular pathogens have evolved mechanisms to usurp and take the control of eukaryotic processes. In the case of Salmonella, this is in part achieved through the cytoplasmic translocation of bacterial effectors capable of acting on the biology of infected cells.
Leone, Philippe, Méresse, Stéphane
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Kinesin-14: the roots of reversal
BMC Biology, 2010 Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes ...
Cross Robert A
doaj +1 more source
Kinesin-5 inhibitor resistance is driven by kinesin-12 [PDF]
Journal of Cell Biology, 2016 The microtubule (MT) cytoskeleton bipolarizes at the onset of mitosis to form the spindle. In animal cells, the kinesin-5 Eg5 primarily drives this reorganization by actively sliding MTs apart. Its primacy during spindle assembly renders Eg5 essential for mitotic progression, demonstrated by the lethal effects of kinesin-5/Eg5 inhibitors (K5Is ...
Stephen R. Norris +3 more
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Role of kinesins in directed adenovirus transport and cytoplasmic exploration
PLoS Pathogens, 2018 Many viruses, including adenovirus, exhibit bidirectional transport along microtubules following cell entry. Cytoplasmic dynein is responsible for microtubule minus end transport of adenovirus capsids after endosomal escape.
Jie Zhou +3 more
semanticscholar +1 more source
Arl3 and RP2 regulate the trafficking of ciliary tip kinesins
Human Molecular Genetics, 2017 Ciliary trafficking defects are the underlying cause of many ciliopathies, including Retinitis Pigmentosa (RP). Anterograde intraflagellar transport (IFT) is mediated by kinesin motor proteins; however, the function of the homodimeric Kif17 motor in ...
N. Schwarz +10 more
semanticscholar +1 more source
Journal of Cell Science, 2004 Dagenbach, E. M. and Endow, S. A. (2004). A new kinesin tree. J. Cell Sci. 117 , [3-7][1]. The neck analysis entries in Table 1 were not aligned correctly in both the print and online versions of this paper. The corrected [Table 1][2] is shown below. We apologise for any inconvenience caused.
Sharyn A. Endow, Elise M. Dagenbach
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OncoTarget, 2017 The MuvB multiprotein complex, together with B-MYB and FOXM1 (MMB-FOXM1), plays an essential role in cell cycle progression by regulating the transcription of genes required for mitosis and cytokinesis.
Patrick Wolter +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source