Results 61 to 70 of about 29,043 (290)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
High-Resolution Imaging of a Single Gliding Protofilament of Tubulins by HS-AFM
Scientific Reports, 2017 In vitro gliding assay of microtubules (MTs) on kinesins has provided us with valuable biophysical and chemo-mechanical insights of this biomolecular motor system.
Jakia Jannat Keya +10 more
doaj +1 more source
Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase
Journal of Cell Biology, 2017 In mitosis, cells undergo a precisely orchestrated series of spatiotemporal changes in cytoskeletal structure to divide their genetic material. These changes are coordinated by a sophisticated network of protein–protein interactions and posttranslational
Sierra N. Cullati +3 more
semanticscholar +1 more source
Dynamics of heterodimeric kinesins and cooperation of kinesins
, 2004 18 pages, 5 ...
Xie, Ping, Dou, Shuo-Xing, Wang, Peng-Ye
openaire +2 more sources
Advanced Functional Materials, EarlyView.The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar +6 more
wiley +1 more source
The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition [PDF]
Open Biology, 2016 Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice.
Jennifer T. Patel +5 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study investigates a synergistic effect between 3D‐printed surface features and mechanical micro‐strain in enhancing the osteogenic, angiogenic, and myogenic responses of human mesenchymal stem cells (hMSCs). Load‐induced mechanotransduction, facilitated by the implant's architectural design, significantly amplifies hMSC differentiation.
Se‐Hwan Lee +9 more
wiley +1 more source
PathogensThe diagnosis of canine leishmaniasis (CanL) still represents a challenge due to the variable clinical manifestations and the large number of asymptomatic dogs.
Henrique C. Teixeira +11 more
doaj +1 more source
Interactions Between Active Matters and Endogenous Fields
Advanced Materials, EarlyView.This review synthesizes endogenous field information and computational methods in contexts such as cancer, wounds, and biofilms. It organizes NAMs and AAMs by sensing, transmitting, and executing functions, compares their limitations, and from these contrasts proposes design strategies for next‐generation AAMs, offering perspectives to foster ...
Jinwei Lin +6 more
wiley +1 more source