Results 61 to 70 of about 23,162 (298)

Molecular motors: design, mechanism and control

, 2008
Biological functions in each animal cell depend on coordinated operations of a wide variety of molecular motors. Some of the these motors transport cargo to their respective destinations whereas some others are mobile workshops which synthesize ...
Chowdhury, Debashish
core   +1 more source

Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7. [PDF]

, 2018
Kinesin-4 motors play important roles in cell division, microtubule organization, and signaling. Understanding how motors perform their functions requires an understanding of their mechanochemical and motility properties.
Blasius, T Lynne, Cochran, Jared C, Grant, Barry J, Jariwala, Shashank, Verhey, Kristen J, Walker, Benjamin, Yue, Yang, Zhang, Stephanie   +7 more
core   +2 more sources

Dorsolateral Cervical Cord T2 Hyperintensity in KIF1C‐Related Disease (Spastic Paraplegia 58): Two Long‐Duration Cases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pathogenic variants in KIF1C cause Spastic Paraplegia 58 (SPG58), typically presenting with cerebellar ataxia and spastic paraparesis. We report two unrelated patients with spastic paraparesis, cerebellar ataxia, and tremor. Whole‐exome sequence analysis identified novel homozygous variants in the motor domain of KIF1C (NM_006612.6): c.921G>A (
Akihiko Mitsutake, Masao Osaki, Takashi Matsukawa, Miho Osako, Chisen Takeuchi, Hiroyuki Ishiura, Jun Mitsui, Ryo Kurokawa, Harushi Mori, Yuji Takahashi, Jun Goto, Shoji Tsuji, Tatsushi Toda   +12 more
wiley   +1 more source

Refinement of the rKLi8.3-Based Serodiagnostic ELISA Allows Detection of Canine Leishmaniosis in Dogs with Low Antibody Titers

Pathogens
The diagnosis of canine leishmaniasis (CanL) still represents a challenge due to the variable clinical manifestations and the large number of asymptomatic dogs.
Henrique C. Teixeira, Giulia P. C. Valle, Rouzbeh Mahdavi, Priscila S. M. Dias, Erick E. de Oliveira, Cristina P. Aira, Daniela Heinz, Andreas Latz, Marta de Lana, Fernanda N. Morgado, Renato Porrozzi, Ulrich Steinhoff   +11 more
doaj   +1 more source

Force and Motion Generation of Molecular Motors: A Generic Description [PDF]

, 1999
We review the properties of biological motor proteins which move along linear filaments that are polar and periodic. The physics of the operation of such motors can be described by simple stochastic models which are coupled to a chemical reaction.
A. Ajdari, A. Ishijima, A.F. Huxley, A.F. Huxley, A.J. Hunt, B. Alberts, C. Shingyoji, C.R. Doering, C.S. Peskin, C.S. Peskin, D. Riveline, D.A. Winkelmann, E. Mandelkow, F. Jülicher, F. Jülicher, F. Jülicher, F.J. Nédélec, H. Fujita, H. Risken, H.E. Huxley, I. Derényi, I.R. Gibbons, J. Prost, J. Rousselet, J.A. Spudich, J.F. Chauwin, J.F. Chauwin, J.T. Finer, J.W.S. Pringle, K Svoboda, K. Svoboda, K. Yasuda, K.A.P. Edman, L. Gorre, L. Gorre-Talini, L.P. Faucheux, M. Büttiker, M. Schnitzer, M.O. Magnasco, P. Reimann, R. Landauer, R.D. Astumian, R.D. Astumian, R.P. Feynman, R.W. Lymn, S. Camalet, S. Leibler, S.J. Kron, S.M. Block, S.P. Gilbert, T. Duke, T. Kreis, T.L. Hill, Y. Harada, Y. Okada   +54 more
core   +3 more sources

Rational Design of Optical Single‐Walled Carbon Nanotube‐Based Nanosensors with Biological Recognition Elements

Advanced Sensor Research, EarlyView.
This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan, Atara Israel, Maria Celina Stefoni, Catarina Ferraz, Ryan M. Williams   +4 more
wiley   +1 more source

The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition [PDF]

Open Biology, 2016
Kinesins that influence the dynamics of microtubule growth and shrinkage require the ability to distinguish between the microtubule end and the microtubule lattice.
Jennifer T. Patel, Hannah R. Belsham, Alexandra J. Rathbone, Bill Wickstead, Christopher Gell, Claire T. Friel   +5 more
doaj   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

The divergent mitotic kinesin MKLP2 exhibits atypical structure and mechanochemistry

eLife, 2017
MKLP2, a kinesin-6, has critical roles during the metaphase-anaphase transition and cytokinesis. Its motor domain contains conserved nucleotide binding motifs, but is divergent in sequence (~35% identity) and size (~40% larger) compared to other kinesins.
Joseph Atherton, I-Mei Yu, Alexander Cook, Joseph M Muretta, Agnel Joseph, Jennifer Major, Yannick Sourigues, Jeffrey Clause, Maya Topf, Steven S Rosenfeld, Anne Houdusse, Carolyn A Moores   +11 more
doaj   +1 more source

Mechanical control of the directional stepping dynamics of the kinesin motor

, 2007
Among the multiple steps constituting the kinesin's mechanochemical cycle, one of the most interesting events is observed when kinesins move an 8-nm step from one microtubule (MT)-binding site to another.
Asenjo, Brady, C. Hyeon, Carter, Coppin, Cross, Dyson, Gilbert, Hancock, J. N. Onuchic, Julicher,, Kaseda, Kolomeisky, Kubelka, Levy, Ma, Moyer, Nishiyama, Onuchic, Ray, Rice, Taniguchi, Thirumalai, Tomishige, Vale, Visscher   +25 more
core   +2 more sources