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Recent advances in plant kinetochore research [PDF]
Frontiers in Cell and Developmental BiologyFaithful chromosome segregation is crucial for cell division in eukaryotes, facilitated by the kinetochore, a multi-subunit protein complex that connects chromosomes to the spindle microtubules.
Elena Kozgunova, Elena Kozgunova
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Quantitative Analysis of Kinetochore Protein Levels and Inter-Kinetochore Distances in Mammalian Cells During Mitosis [PDF]
Bio-ProtocolThe mammalian kinetochore is a multi-layered protein complex that forms on the centromeric chromatin. The kinetochore serves as the attachment hub for the plus ends of microtubules emanating from the centrosomes during mitosis.
Neeraj Wasnik +4 more
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Meiosis-specific distal cohesion site decoupled from the kinetochore [PDF]
Nature CommunicationsPrimary constriction of the M-phase chromosome serves as a marker for the kinetochore position. Underlying this observation is the concept that the kinetochore is spatially linked with the pericentromere where sister-chromatids are cohered. Here, we find
Bo Pan +3 more
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Kinetochore Architecture Employs Diverse Linker Strategies Across Evolution
Frontiers in Cell and Developmental Biology, 2022 The assembly of a functional kinetochore on centromeric chromatin is necessary to connect chromosomes to the mitotic spindle, ensuring accurate chromosome segregation.
Shreyas Sridhar, Tatsuo Fukagawa
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Frontiers in Cellular and Infection Microbiology, 2021 Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer kinetochore network that binds to microtubules.
Lorenzo Brusini +6 more
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Biochemical evidence for diverse strategies in the inner kinetochore [PDF]
Open Biology, 2020 The kinetochore is a complex structure whose function is absolutely essential. Unlike the centromere, the kinetochore at first appeared remarkably well conserved from yeast to humans, especially the microtubule-binding outer kinetochore.
G. E. Hamilton, T. N. Davis
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A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans. [PDF]
PLoS Genetics, 2012 Unlike most eukaryotes, a kinetochore is fully assembled early in the cell cycle in budding yeasts Saccharomyces cerevisiae and Candida albicans. These kinetochores are clustered together throughout the cell cycle.
Jitendra Thakur, Kaustuv Sanyal
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Cell cycle control of kinetochore assembly
Nucleus, 2022 The kinetochore is a large proteinaceous structure assembled on the centromeres of chromosomes. The complex machinery links chromosomes to the mitotic spindle and is essential for accurate chromosome segregation during cell division.
Qianhua Dong, Fei Li
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The Mub1/Ubr2 ubiquitin ligase complex regulates the conserved Dsn1 kinetochore protein. [PDF]
PLoS Genetics, 2013 The kinetochore is the macromolecular complex that assembles onto centromeric DNA and orchestrates the segregation of duplicated chromosomes. More than 60 components make up the budding yeast kinetochore, including inner kinetochore proteins that bind to
Bungo Akiyoshi +5 more
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PLoS Genetics, 2021 The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-
Michael Bokros +3 more
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