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Recent advances in plant kinetochore research [PDF]

Frontiers in Cell and Developmental Biology
Faithful chromosome segregation is crucial for cell division in eukaryotes, facilitated by the kinetochore, a multi-subunit protein complex that connects chromosomes to the spindle microtubules.
Elena Kozgunova, Elena Kozgunova
doaj   +2 more sources

Quantitative Analysis of Kinetochore Protein Levels and Inter-Kinetochore Distances in Mammalian Cells During Mitosis [PDF]

Bio-Protocol
The mammalian kinetochore is a multi-layered protein complex that forms on the centromeric chromatin. The kinetochore serves as the attachment hub for the plus ends of microtubules emanating from the centrosomes during mitosis.
Neeraj Wasnik, Mahima Singhal, Sukirti Khantwal, Sanghamitra Mylavarapu, Sivaram Mylavarapu   +4 more
doaj   +2 more sources

HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. [PDF]

, 2001
Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Albertson, Albertson, Albertson, Amon, Buchwitz, Dernburg, Fire, Gonczy, Harlow, Heald, Hedgecock, Hodgkin, Howman, Kainta, Kimble, Lombillo, Maney, McDonald, McEwen, Mello, Moore, Nabetani, Newman, Nicklas, O'Connell, Rappleye, Roos, Savoian, Shah, Sharp, Sharp, Wigge, Yanagida, Yao   +33 more
core   +3 more sources

Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore [PDF]

Nature Communications
Multiple microtubule-directed activities concentrate on mitotic chromosomes to ensure their faithful segregation. These include couplers and dynamics regulators localized at the kinetochore, the microtubule interface built on centromeric chromatin, as ...
Bram Prevo, Dhanya K. Cheerambathur, William C. Earnshaw, Arshad Desai   +3 more
doaj   +2 more sources

Meiosis-specific distal cohesion site decoupled from the kinetochore [PDF]

Nature Communications
Primary constriction of the M-phase chromosome serves as a marker for the kinetochore position. Underlying this observation is the concept that the kinetochore is spatially linked with the pericentromere where sister-chromatids are cohered. Here, we find
Bo Pan, Melania Bruno, Todd S. Macfarlan, Takashi Akera   +3 more
doaj   +2 more sources

Plant kinetochore complex: composition, function, and regulation [PDF]

Frontiers in Plant Science
The kinetochore complex, an important protein assembly situated on the centromere, plays a pivotal role in chromosome segregation during cell division.
Yuqian Xie, Mingliang Wang, Beixin Mo, Beixin Mo, Chao Liang, Chao Liang   +5 more
doaj   +2 more sources

On the possibility of yet a third kinetochore system in the protist phylum Euglenozoa [PDF]

mBio
Transmission of genetic material from one generation to the next is a fundamental feature of all living cells. In eukaryotes, a macromolecular complex called the kinetochore plays crucial roles during chromosome segregation by linking chromosomes to ...
Corinna Benz, Maximilian W. D. Raas, Pragya Tripathi, Drahomíra Faktorová, Eelco C. Tromer, Bungo Akiyoshi, Julius Lukeš   +6 more
doaj   +2 more sources

Kinetochore Architecture Employs Diverse Linker Strategies Across Evolution

Frontiers in Cell and Developmental Biology, 2022
The assembly of a functional kinetochore on centromeric chromatin is necessary to connect chromosomes to the mitotic spindle, ensuring accurate chromosome segregation.
Shreyas Sridhar, Tatsuo Fukagawa
doaj   +1 more source

Cell cycle control of kinetochore assembly

Nucleus, 2022
The kinetochore is a large proteinaceous structure assembled on the centromeres of chromosomes. The complex machinery links chromosomes to the mitotic spindle and is essential for accurate chromosome segregation during cell division.
Qianhua Dong, Fei Li
doaj   +1 more source

Biochemical evidence for diverse strategies in the inner kinetochore [PDF]

Open Biology, 2020
The kinetochore is a complex structure whose function is absolutely essential. Unlike the centromere, the kinetochore at first appeared remarkably well conserved from yeast to humans, especially the microtubule-binding outer kinetochore.
G. E. Hamilton, T. N. Davis
doaj   +1 more source