Results 91 to 100 of about 115,854 (373)
Human kinetochores are swivel joints that mediate microtubule attachments
eLife, 2016 Chromosome segregation is a mechanical process that requires assembly of the mitotic spindle – a dynamic microtubule-based force-generating machine.
Chris A Smith +2 more
doaj +1 more source
The kinetochore–microtubule interface at a glance
Journal of Cell Science, 2018 Accurate chromosome segregation critically depends on the formation of attachments between microtubule polymers and each sister chromatid. The kinetochore is the macromolecular complex that assembles at the centromere of each chromosome during mitosis ...
Julie K. Monda, I. Cheeseman
semanticscholar +1 more source
Molecular Oncology, EarlyView.Gao et al. report that circular DNA molecules created as by‐products of V(D)J recombination during lymphocyte maturation (ESCs) can replicate and be retained for much longer than previously thought in healthy cells. In BCP‐ALL cells, increased ESC abundance correlates with a greater chance of relapse likely mediated by their ability to induce genome ...
Davide Pradella, Andrea Ventura
wiley +1 more source
PLoS Genetics, 2019 The kinetochore is the central molecular machine that drives chromosome segregation in all eukaryotes. Genetic studies have suggested that protein sumoylation plays a role in regulating the inner kinetochore; however, the mechanism remains elusive. Here,
Raymond T Suhandynata +5 more
doaj +1 more source
The Journal of Cell Biology, 2006 ![][1] Overproduced CENP-A (green) induces an ectopic kinetochore (blue) with attached microtubule (red). KARPEN/ELSEVIER Extra functional kinetochores can be created by overexpressing just a single protein, according to Patrick Heun, Sylvia Erhardt, Gary Karpen (University ...
openaire +3 more sources
Human Shugoshin Mediates Kinetochore-Driven Formation of Kinetochore Microtubules [PDF]
Cell Cycle, 2006 The conserved protein Shugoshin (Sgo) plays a role in the maintenance of centromeric cohesion in mitosis and meiosis. Human Shugoshin (hSgo) was first identified as an overexpressed protein in breast cancers. Here we demonstrate that hSgo mediates kinetochore-driven formation of kinetochore -microtubules (MTs) during bipolar spindle assembly.
Megumi Tsuji +5 more
openaire +3 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Bio-ProtocolThe mammalian kinetochore is a multi-layered protein complex that forms on the centromeric chromatin. The kinetochore serves as the attachment hub for the plus ends of microtubules emanating from the centrosomes during mitosis.
Neeraj Wasnik +4 more
doaj +1 more source
Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores
Cells, 2019 Faithful chromosome segregation during mitosis is crucial for maintaining genome stability. The spindle assembly checkpoint (SAC) is a surveillance mechanism that ensures accurate mitotic progression.
Zhen Dou +5 more
doaj +1 more source
bioRxiv, 2018 Proper kinetochore-microtubule attachments, mediated by the NDC80 complex, are required for error-free chromosome segregation. Erroneous attachments are corrected by the tension dependence of kinetochore-microtubule interactions.
Tae Yeon Yoo +5 more
semanticscholar +1 more source