Results 91 to 100 of about 36,378 (225)
The condensin complex is required for proper spindle assembly and chromosome segregation in Xenopus egg extracts. [PDF]
, 2003 Chromosome condensation is required for the physical resolution and segregation of sister chromatids during cell division, but the precise role of higher order chromatin structure in mitotic chromosome functions is unclear.
Deehan, Renee +3 more
core +4 more sources
mSphere, 2018 Kinetochore clustering, frequently observed in yeasts, plays a key role in genome organization and chromosome segregation. In the absence of the metaphase plate arrangement, kinetochore clustering in yeast species is believed to facilitate timely ...
Vikas Yadav, Kaustuv Sanyal
doaj +1 more source
The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation [PDF]
, 2015 Unlike other organisms that have evolved distinct H2A variants for different functions, Drosophila melanogaster has just one variant which is capable of filling many roles.
Cenci, Giovanni, Verni', Fiammetta
core +1 more source
Establishment of the vertebrate kinetochores [PDF]
Chromosome Research, 2012 The centromere is essential for accurate chromosome segregation during mitosis and meiosis to achieve transmission of genetic information to daughter cells. To facilitate accurate chromosome segregation, the centromere serves several specific functions, including microtubule binding, spindle-checkpoint control, and sister chromatid cohesion.
Tatsuo Fukagawa, Tetsuya Hori
openaire +3 more sources
The Saccharomyces cerevisiae kinetochore [PDF]
FEBS Letters, 1996 Accurate chromosome segregation is DApenDAnt on a specialized chromosomal structure, the kinetochore/centromere. The only essential constituent of the S. cerevisiae kinetochore established today is CBF3, a multisubunit complex that binds to S. cerevisiae centromere DNA.
Johannes Lechner, Jennifer Ortiz
openaire +2 more sources
AI-Assisted Forward Modeling of Biological Structures
Frontiers in Cell and Developmental Biology, 2019 The rise of machine learning and deep learning technologies have allowed researchers to automate image classification. We describe a method that incorporates automated image classification and principal component analysis to evaluate computational models
Josh Lawrimore +3 more
doaj +1 more source
European Journal of Cell Biology, 2012 The multiple functions of kinetochores are reflected in their complex composition, with over a hundred different proteins, which self-associate in several functional subcomplexes. Most of these kinetochore proteins were identified over the last 10-12 years using a combination of genetic, cell biological, biochemical, and bioinformatic approaches in ...
openaire +5 more sources
Reconstruction of the kinetochore: a prelude to meiosis [PDF]
Cell Division, 2007 Abstract In eukaryotic organisms, chromosomes are spatially organized within the nucleus. Such nuclear architecture provides a physical framework for the genetic activities of chromosomes, and changes its functional organization as the cell moves through the phases of the cell cycle.
Yasushi Hiraoka +4 more
openaire +4 more sources
BUB-1 promotes amphitelic chromosome biorientation via multiple activities at the kinetochore
eLife, 2018 Accurate chromosome segregation relies on bioriented amphitelic attachments of chromosomes to microtubules of the mitotic spindle, in which sister chromatids are connected to opposite spindle poles.
Frances Edwards +4 more
doaj +1 more source
Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis [PDF]
, 2007 Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors.
Clarke, Alan +9 more
core +4 more sources