Results 91 to 100 of about 117,673 (373)

Recent advances in plant kinetochore research

Frontiers in Cell and Developmental Biology
Faithful chromosome segregation is crucial for cell division in eukaryotes, facilitated by the kinetochore, a multi-subunit protein complex that connects chromosomes to the spindle microtubules.
Elena Kozgunova, Elena Kozgunova
doaj   +1 more source

The kinetochore–microtubule interface at a glance

Journal of Cell Science, 2018
Accurate chromosome segregation critically depends on the formation of attachments between microtubule polymers and each sister chromatid. The kinetochore is the macromolecular complex that assembles at the centromere of each chromosome during mitosis ...
Julie K. Monda, I. Cheeseman
semanticscholar   +1 more source

DNA content of a functioning chicken kinetochore [PDF]

, 2014
© The Author(s) 2014. In order to understand the three-dimensional structure of the functional kinetochore in vertebrates, we require a complete list and stoichiometry for the protein components of the kinetochore, which can be provided by genetic and ...
A Alonso, AE Barry, AF Pluta, AP Joglekar, BA Sullivan, BR Brinkley, CM Wade, D Gerlich, D Sart du, D Varma, DR Foltz, FG Westhorpe, H Maiato, H Saitoh, IM Cheeseman, J Dekker, JH Hegemann, K Jaqaman, LL Sullivan, LS Burrack, MD Blower, N Naumova, O Capozzi, OJ Marshall, P Luykx, P Vagnarelli, Paola Vagnarelli, PT Jokelainen, R Saffery, SA Ribeiro, SA Ribeiro, Susana Abreu Ribeiro, T Fukagawa, T Hori, WC Earnshaw, WC Earnshaw, WH Shang, WH Shang, William C. Earnshaw, X Wan   +39 more
core   +3 more sources

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

Plant kinetochore complex: composition, function, and regulation

Frontiers in Plant Science
The kinetochore complex, an important protein assembly situated on the centromere, plays a pivotal role in chromosome segregation during cell division.
Yuqian Xie, Mingliang Wang, Beixin Mo, Beixin Mo, Chao Liang, Chao Liang   +5 more
doaj   +1 more source

Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes

eLife, 2020
The spindle generates force to segregate chromosomes at cell division. In mammalian cells, kinetochore-fibers connect chromosomes to the spindle. The dynamic spindle anchors kinetochore-fibers in space and time to move chromosomes.
Pooja Suresh, Alexandra F Long, Sophie Dumont   +2 more
doaj   +1 more source

Trypanosome outer kinetochore proteins suggest conservation of chromosome segregation machinery across eukaryotes

Journal of Cell Biology, 2017
Kinetochores are multiprotein complexes that couple eukaryotic chromosomes to the mitotic spindle to ensure proper segregation. The model for kinetochore assembly is conserved between humans and yeast, and homologues of several components are widely ...
Simon D’Archivio, B. Wickstead
semanticscholar   +1 more source

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

Advanced Science, EarlyView.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian, Jiatong Li, Jingyi Kang, Xiangning Xu, Bicheng Wang, Shuo Lou, Jingyu Li, Yuying Yang, Yanbing Zhang, Yangzi Zheng, Jing Weng, Yuanjing Liang, Wei Ma   +12 more
wiley   +1 more source

The roles of kinetochore of micronucleus in mitosis of HeLa cells: a live cell imaging study

Cancer Cell International, 2019
Background Micronuclei (MNi) are extensively used to evaluate genotoxic effects and chromosome instability. However, the roles of kinetochore of MN in mitosis have not been completely addressed.
Erkang Jiang, Lianping Wei, Fang Tao, Mei Yu, Shu Wang, Xiuhong Zhou, Daxiang Li, Zhongwen Xie   +7 more
doaj   +1 more source

Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments

bioRxiv, 2018
Proper kinetochore-microtubule attachments, mediated by the NDC80 complex, are required for error-free chromosome segregation. Erroneous attachments are corrected by the tension dependence of kinetochore-microtubule interactions.
Tae Yeon Yoo, Jeong-Mo Choi, W. Conway, Che-Hang Yu, R. Pappu, D. Needleman   +5 more
semanticscholar   +1 more source