Results 11 to 20 of about 115,854 (373)
Structural plasticity of the living kinetochore [PDF]
Journal of Cell Biology, 2017 The kinetochore is a large, evolutionarily conserved protein structure that connects chromosomes with microtubules. During chromosome segregation, outer kinetochore components track depolymerizing ends of microtubules to facilitate the separation of ...
Karthik Dhatchinamoorthy +6 more
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Mosaic origin of the eukaryotic kinetochore [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Eukaryotes, which include diverse species like animals, fungi, and plants, have cells that are fundamentally more complex than prokaryotic cells, such as bacteria.
E. Tromer +3 more
semanticscholar +7 more sources
Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore
Nature Communications, 2023 Multiple microtubule-directed activities concentrate on mitotic chromosomes to ensure their faithful segregation. These include couplers and dynamics regulators localized at the kinetochore, the microtubule interface built on centromeric chromatin, as ...
Bram Prevo +3 more
doaj +6 more sources
Kinetochore inactivation by expression of a repressive mRNA [PDF]
eLife, 2017 Differentiation programs such as meiosis depend on extensive gene regulation to mediate cellular morphogenesis. Meiosis requires transient removal of the outer kinetochore, the complex that connects microtubules to chromosomes.
Jingxun Chen +8 more
semanticscholar +4 more sources
Chromosome Segregation Is Biased by Kinetochore Size [PDF]
Current Biology, 2018 Chromosome missegregation during mitosis or meiosis is a hallmark of cancer and the main cause of prenatal death in humans. The gain or loss of specific chromosomes is thought to be random, with cell viability being essentially determined by selection ...
Danica Drpic +8 more
semanticscholar +3 more sources
Frontiers in Cellular and Infection Microbiology, 2021 Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer kinetochore network that binds to microtubules.
Lorenzo Brusini +6 more
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The Mub1/Ubr2 ubiquitin ligase complex regulates the conserved Dsn1 kinetochore protein. [PDF]
PLoS Genetics, 2013 The kinetochore is the macromolecular complex that assembles onto centromeric DNA and orchestrates the segregation of duplicated chromosomes. More than 60 components make up the budding yeast kinetochore, including inner kinetochore proteins that bind to
Bungo Akiyoshi +5 more
doaj +1 more source
Biochemical evidence for diverse strategies in the inner kinetochore [PDF]
Open Biology, 2020 The kinetochore is a complex structure whose function is absolutely essential. Unlike the centromere, the kinetochore at first appeared remarkably well conserved from yeast to humans, especially the microtubule-binding outer kinetochore.
G. E. Hamilton, T. N. Davis
doaj +1 more source
Insights into the Kinetochore [PDF]
Structure, 2008 The Ndc80 complex is a core component of the kinetochore, which links chromosomes to microtubules. Recently, Ciferri et al. (2008) published an atomic-level structure of the complex with implications for kinetochore architecture and for the generation and control of chromosome movements during mitosis.
Charles L. Asbury, Trisha N. Davis
openaire +2 more sources
Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells
Journal of Cell Biology, 2020 Broad et al. investigate multiple populations of Aurora B kinase at the centromere and kinetochore. Two distinct histone modifications initiate pathways that individually recruit Aurora B to spatially distinct centromeric regions, and neither pathway is ...
A. Broad, Keith F. DeLuca, J. DeLuca
semanticscholar +1 more source