Results 11 to 20 of about 36,378 (225)
A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans. [PDF]
PLoS Genetics, 2012 Unlike most eukaryotes, a kinetochore is fully assembled early in the cell cycle in budding yeasts Saccharomyces cerevisiae and Candida albicans. These kinetochores are clustered together throughout the cell cycle.
Jitendra Thakur, Kaustuv Sanyal
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer kinetochore network that binds to microtubules.
Lorenzo Brusini +6 more
doaj +1 more source
The Mub1/Ubr2 ubiquitin ligase complex regulates the conserved Dsn1 kinetochore protein. [PDF]
PLoS Genetics, 2013 The kinetochore is the macromolecular complex that assembles onto centromeric DNA and orchestrates the segregation of duplicated chromosomes. More than 60 components make up the budding yeast kinetochore, including inner kinetochore proteins that bind to
Bungo Akiyoshi +5 more
doaj +1 more source
Insights into the Kinetochore [PDF]
Structure, 2008 The Ndc80 complex is a core component of the kinetochore, which links chromosomes to microtubules. Recently, Ciferri et al. (2008) published an atomic-level structure of the complex with implications for kinetochore architecture and for the generation and control of chromosome movements during mitosis.
Charles L. Asbury, Trisha N. Davis
openaire +2 more sources
The ultrastructure of the kinetochore and kinetochore fiber in Drosophila somatic cells [PDF]
Chromosoma, 2006 Drosophila melanogaster is a widely used model organism for the molecular dissection of mitosis in animals. However, despite the popularity of this system, no studies have been published on the ultrastructure of Drosophila kinetochores and kinetochore fibers (K-fibers) in somatic cells.
Sara Moutinho-Pereira +8 more
openaire +4 more sources
Synergistic Control of Kinetochore Protein Levels by Psh1 and Ubr2. [PDF]
PLoS Genetics, 2016 The accurate segregation of chromosomes during cell division is achieved by attachment of chromosomes to the mitotic spindle via the kinetochore, a large multi-protein complex that assembles on centromeres.
Eva Herrero, Peter H Thorpe
doaj +1 more source
The life and miracles of kinetochores [PDF]
The EMBO Journal, 2009 Kinetochores are large protein assemblies built on chromosomal loci named centromeres. The main functions of kinetochores can be grouped under four modules. The first module, in the inner kinetochore, contributes a sturdy interface with centromeric chromatin. The second module, the outer kinetochore, contributes a microtubule-binding interface.
Santaguida, Stefano, Musacchio, Andrea
openaire +3 more sources
Integrating Functions at the Kinetochore [PDF]
Cell, 2002 Kinetochore components have catalytic as well as structural activities. New evidence illustrates how these proteins integrate spindle morphogenesis with regulation of the timing and accuracy of chromosome segregation.
Frank Solomon, Soni L. Shimoda
openaire +2 more sources
Tension Management in the Kinetochore [PDF]
Current Biology, 2010 The kinetochore is the protein machine built at the centromere that integrates mechanical force and chemical energy from dynamic microtubules into directed chromosome motion. The kinetochore also provides a powerful signaling function that is able to alter the properties of the spindle checkpoint and initiate a signal transduction cascade that leads to
Elaine Y Yeh, Kerry Bloom
openaire +3 more sources
Kinetochore structure: electron spectroscopic imaging of the kinetochore. [PDF]
The Journal of cell biology, 1989 The structure of the kinetochore in thin section has been studied in the Indian muntjac by an electron spectroscopic imaging technique. This procedures allows the analysis of the distribution of phosphorus within the layers of the kinetochore. The results indicate that this element is a major component of both the inner and outer plates whereas it is ...
David P. Bazett-Jones, Jerome B. Rattner
openaire +3 more sources