Results 11 to 20 of about 117,673 (373)

Structural plasticity of the living kinetochore [PDF]

Journal of Cell Biology, 2017
The kinetochore is a large, evolutionarily conserved protein structure that connects chromosomes with microtubules. During chromosome segregation, outer kinetochore components track depolymerizing ends of microtubules to facilitate the separation of ...
Karthik Dhatchinamoorthy, M. Shivaraju, Jeffrey J. Lange, B. Rubinstein, J. Unruh, Brian D. Slaughter, J. Gerton   +6 more
semanticscholar   +3 more sources

Chromosome Segregation Is Biased by Kinetochore Size [PDF]

Current Biology, 2018
Chromosome missegregation during mitosis or meiosis is a hallmark of cancer and the main cause of prenatal death in humans. The gain or loss of specific chromosomes is thought to be random, with cell viability being essentially determined by selection ...
Danica Drpic, Ana C. Almeida, P. Aguiar, F. Renda, Joana Damas, H. Lewin, D. Larkin, A. Khodjakov, H. Maiato   +8 more
semanticscholar   +4 more sources

A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans. [PDF]

PLoS Genetics, 2012
Unlike most eukaryotes, a kinetochore is fully assembled early in the cell cycle in budding yeasts Saccharomyces cerevisiae and Candida albicans. These kinetochores are clustered together throughout the cell cycle.
Jitendra Thakur, Kaustuv Sanyal
doaj   +1 more source

Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex

Frontiers in Cellular and Infection Microbiology, 2021
Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer kinetochore network that binds to microtubules.
Lorenzo Brusini, Lorenzo Brusini, Simon D’Archivio, Simon D’Archivio, Jennifer McDonald, Jennifer McDonald, Bill Wickstead   +6 more
doaj   +1 more source

The Mub1/Ubr2 ubiquitin ligase complex regulates the conserved Dsn1 kinetochore protein. [PDF]

PLoS Genetics, 2013
The kinetochore is the macromolecular complex that assembles onto centromeric DNA and orchestrates the segregation of duplicated chromosomes. More than 60 components make up the budding yeast kinetochore, including inner kinetochore proteins that bind to
Bungo Akiyoshi, Christian R Nelson, Nicole Duggan, Steven Ceto, Jeffrey A Ranish, Sue Biggins   +5 more
doaj   +1 more source

Biochemical evidence for diverse strategies in the inner kinetochore [PDF]

Open Biology, 2020
The kinetochore is a complex structure whose function is absolutely essential. Unlike the centromere, the kinetochore at first appeared remarkably well conserved from yeast to humans, especially the microtubule-binding outer kinetochore.
G. E. Hamilton, T. N. Davis
doaj   +1 more source

Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells

Journal of Cell Biology, 2020
Broad et al. investigate multiple populations of Aurora B kinase at the centromere and kinetochore. Two distinct histone modifications initiate pathways that individually recruit Aurora B to spatially distinct centromeric regions, and neither pathway is ...
A. Broad, Keith F. DeLuca, J. DeLuca
semanticscholar   +1 more source

CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes [PDF]

, 2020
Accurate chromosome segregation demands efficient capture of microtubules by kinetochores and their conversion to stable bioriented attachments that can congress and then segregate chromosomes.
Allan, Andrew D. McAinsh, Auckland, Bancroft, Baumbach, Berto, Berto, Bolhy, Bomont, Chan, Ciossani, Currie, DeSantis, Dix, Dudka, Emanuele Roscioli, Etemad, Faulkner, Feng, Filges, Gama, Gassmann, Gutierrez, Haley, Helena Louise Elvidge Coker, Helgeson, Hoffman, Holt, Howell, Huang, Huis In ’t Veld, Johnson, Kanfer, Kanfer, Klinman, Kuhn, Liu, Magidson, Magidson, Maiato, McEwen, McEwen, McKinley, Meraldi, Monda, Moughamian, Musacchio, Musacchio, Musinipally, Olenick, Olziersky, Pandey, Pereira, Peterka, Philip Auckland, Raaijmakers, Ran, Rattner, Rodriguez-Rodriguez, Roscioli, Sacristan, Samejima, Schmidt, Shao, Shrestha, Siller, Simões, Stehman, Tai, Thrower, Toropova, Vagnoni, Vergnolle, Volkov, Wojcik, Wynne, Wynne, Wynne, Yang, Yi, Zhu   +80 more
core   +1 more source

Assembly principles and stoichiometry of a complete human kinetochore module

Science Advances, 2020
Biochemical reconstitution of human kinetochore delivers complexes with all subunits in the expected stoichiometry. Centromeres are epigenetically determined chromosomal loci that seed kinetochore assembly to promote chromosome segregation during cell ...
K. Walstein, Arsen Petrovic, D. Pan, Birte Hagemeier, Doro Vogt, I. Vetter, A. Musacchio   +6 more
semanticscholar   +1 more source

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.

PLoS Genetics, 2021
The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-
Michael Bokros, Delaney Sherwin, Marie-Helene Kabbaj, Yanchang Wang   +3 more
doaj   +1 more source