Results 21 to 30 of about 117,673 (373)

Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface

Frontiers in Cell and Developmental Biology, 2020
Successful mitotic cell division is critically dependent on the formation of correct attachments between chromosomes and spindle microtubules. Microtubule attachments are mediated by kinetochores, which are large proteinaceous structures assembled on ...
Robert T. Wimbish, J. DeLuca
semanticscholar   +1 more source

Visualizing kinetochore architecture [PDF]

Current Opinion in Structural Biology, 2011
Kinetochores are large macromolecular assemblies that link chromosomes to spindle microtubules (MTs) during mitosis. Here we review recent advances in the study of core MT-binding kinetochore complexes using electron microcopy methods in vitro and nanometer-accuracy fluorescence microscopy in vivo.
Gregory, Alushin, Eva, Nogales
openaire   +2 more sources

Stretching the Rules: Monocentric Chromosomes with Multiple Centromere Domains [PDF]

, 2012
The centromere is a functional chromosome domain that is essential for faithful chromosome segregation during cell division and that can be reliably identified by the presence of the centromere-specific histone H3 variant CenH3.
A Kawabe, AE Hall, AF Dernburg, Alice Navrátilová, Andrea Koblížková, AW Higgins, BA Sullivan, BE Black, Beth A. Sullivan, DA Pepper, E Schroeder-Reiter, Elizabeth Schroeder-Reiter, Eva Chocholová, Gerhard Wanner, HR Lee, HS Malik, HS Malik, IC Moraes, J Macas, J Monen, Jiří Macas, JM Jiang, K Nagaki, K Nagaki, K Prufer, M Plohl, M Sanei, MD Bennett, OJ Marshall, P Binarova, P Neumann, P Neumann, P Neumann, P Novák, Pavel Neumann, PB Talbert, Petr Novák, PW Barlow, R ten Hoopen, RJ McFarlane, RK Dawe, S Heckmann, SA Ribeiro, T Haizel, Veronika Steinbauerová, W Zhang   +45 more
core   +13 more sources

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae [PDF]

, 2014
The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Here we
Corbishley, Stephen, Makrantoni, Vasso, Morrice, Nicholas A., Rachidi, Najma, Robinson, David A., Stark, Michael J. R.   +5 more
core   +9 more sources

A Molecular View of Kinetochore Assembly and Function

Biology, 2017
Kinetochores are large protein assemblies that connect chromosomes to microtubules of the mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to its daughters.
A. Musacchio, A. Desai
semanticscholar   +1 more source

The Kinetochore [PDF]

Cold Spring Harbor Perspectives in Biology, 2014
A critical requirement for mitosis is the distribution of genetic material to the two daughter cells. The central player in this process is the macromolecular kinetochore structure, which binds to both chromosomal DNA and spindle microtubule polymers to direct chromosome alignment and segregation. This review will discuss the key kinetochore activities
openaire   +2 more sources

Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner. [PDF]

, 2019
The spindle assembly checkpoint (SAC) prevents anaphase until all kinetochores attach to the spindle. Each mammalian kinetochore binds many microtubules, but how many attached microtubules are required to turn off the checkpoint, and how the kinetochore ...
Akiyoshi, Alushin, Aravamudhan, Ballister, Barisic, Cane, Cheeseman, Chen, Ciferri, Clute, David, De Antoni, DeLuca, DeLuca, DeLuca, Dick, Dudka, Elting, Elting, Etemad, Etemad, Funabiki, Gassmann, Guimaraes, Hengeveld, Hewitt, Hiruma, Howell, Howell, Hueschen, Janssen, Jelluma, Ji, Johnston, Jonathan Kuhn, Kajtez, Khodjakov, Kuhn, London, Long, Lukinavičius, Maciejowski, Magidson, Maldonado, Maresca, Martin-Lluesma, Matson, McEwen, McIntosh, McKinley, Nijenhuis, Orth, O’Connell, Peterson, Pinsky, Rieder, Rieder, Santaguida, Sarangapani, Saurin, Shah, Sikirzhytski, Sikirzhytski, Sivakumar, Sophie Dumont, Sundin, Suzuki, Suzuki, Tanaka, Tauchman, Uchida, Uetake, Vanoosthuyse, Volkov, Wan, Waters, Wendell, Wojcik, Yoo, Zaytsev, Zaytsev   +80 more
core   +1 more source

Characterization of unconventional kinetochore kinases KKT10 and KKT19 in Trypanosoma brucei

Journal of Cell Science, 2020
The kinetochore is a macromolecular protein complex that drives chromosome segregation in eukaryotes. Unlike most eukaryotes that have canonical kinetochore proteins, evolutionarily divergent kinetoplastids, such as Trypanosoma brucei, have ...
M. Ishii, B. Akiyoshi
semanticscholar   +1 more source

Structure of the inner kinetochore CCAN complex assembled onto a centromeric nucleosome

Nature, 2019
In eukaryotes, accurate chromosome segregation in mitosis and meiosis maintains genome stability and prevents aneuploidy. Kinetochores are large protein complexes that, by assembling onto specialized Cenp-A nucleosomes1,2, function to connect centromeric
K. Yan, Jing Yang, Ziguo Zhang, S. McLaughlin, Leifu Chang, Domenico Fascì, A. Ehrenhofer-Murray, A. Heck, D. Barford   +8 more
semanticscholar   +1 more source

Kinetochore-bound Mps1 regulates kinetochore–microtubule attachments via Ndc80 phosphorylation [PDF]

Journal of Cell Biology, 2021
Dividing cells detect and correct erroneous kinetochore–microtubule attachments during mitosis, thereby avoiding chromosome missegregation. The Aurora B kinase phosphorylates microtubule-binding elements specifically at incorrectly attached kinetochores, promoting their release and providing another chance for proper attachments to form.
Krishna K. Sarangapani, Lori B. Koch, Christian R. Nelson, Charles L. Asbury, Sue Biggins   +4 more
openaire   +2 more sources