Results 21 to 30 of about 36,378 (225)

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.

PLoS Genetics, 2021
The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-
Michael Bokros, Delaney Sherwin, Marie-Helene Kabbaj, Yanchang Wang   +3 more
doaj   +1 more source

DNA content of a functioning chicken kinetochore [PDF]

, 2014
© The Author(s) 2014. In order to understand the three-dimensional structure of the functional kinetochore in vertebrates, we require a complete list and stoichiometry for the protein components of the kinetochore, which can be provided by genetic and ...
A Alonso, AE Barry, AF Pluta, AP Joglekar, BA Sullivan, BR Brinkley, CM Wade, D Gerlich, D Sart du, D Varma, DR Foltz, FG Westhorpe, H Maiato, H Saitoh, IM Cheeseman, J Dekker, JH Hegemann, K Jaqaman, LL Sullivan, LS Burrack, MD Blower, N Naumova, O Capozzi, OJ Marshall, P Luykx, P Vagnarelli, Paola Vagnarelli, PT Jokelainen, R Saffery, SA Ribeiro, SA Ribeiro, Susana Abreu Ribeiro, T Fukagawa, T Hori, WC Earnshaw, WC Earnshaw, WH Shang, WH Shang, William C. Earnshaw, X Wan   +39 more
core   +3 more sources

CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes [PDF]

, 2020
Accurate chromosome segregation demands efficient capture of microtubules by kinetochores and their conversion to stable bioriented attachments that can congress and then segregate chromosomes.
Allan, Andrew D. McAinsh, Auckland, Bancroft, Baumbach, Berto, Berto, Bolhy, Bomont, Chan, Ciossani, Currie, DeSantis, Dix, Dudka, Emanuele Roscioli, Etemad, Faulkner, Feng, Filges, Gama, Gassmann, Gutierrez, Haley, Helena Louise Elvidge Coker, Helgeson, Hoffman, Holt, Howell, Huang, Huis In ’t Veld, Johnson, Kanfer, Kanfer, Klinman, Kuhn, Liu, Magidson, Magidson, Maiato, McEwen, McEwen, McKinley, Meraldi, Monda, Moughamian, Musacchio, Musacchio, Musinipally, Olenick, Olziersky, Pandey, Pereira, Peterka, Philip Auckland, Raaijmakers, Ran, Rattner, Rodriguez-Rodriguez, Roscioli, Sacristan, Samejima, Schmidt, Shao, Shrestha, Siller, Simões, Stehman, Tai, Thrower, Toropova, Vagnoni, Vergnolle, Volkov, Wojcik, Wynne, Wynne, Wynne, Yang, Yi, Zhu   +80 more
core   +1 more source

The path of DNA in the kinetochore [PDF]

Current Biology, 2006
The kinetochore is the protein-DNA complex at eukaryotic centromeres that functions as the attachment site for spindle microtubules. In budding yeast, the centromere spans 120 bp, there is a single microtubule per kinetochore, and the entire spindle is composed of 16 kinetochore microtubules plus four interpolar microtubules from each pole.
Shantanu Sharma, Kerry Bloom, Nikolay V. Dokholyan   +2 more
openaire   +3 more sources

Structural plasticity of the living kinetochore [PDF]

, 2017
The kinetochore is a large, evolutionarily conserved protein structure that connects chromosomes with microtubules. During chromosome segregation, outer kinetochore components track depolymerizing ends of microtubules to facilitate the separation of ...
Akiyoshi, Al-Bassam, Aravamudhan, Aravamudhan, Asbury, Biggins, Biggins, Boris Rubinstein, Brian D. Slaughter, Chan, Cheeseman, Culotti, Daniel, De Wulf, Desai, Duffy, Field, Foley, Gandhi, Gao, Gardner, Gestaut, Grishchuk, Guimaraes, Hartwell, He, Hedges, Hill, Hornung, Hornung, Jaspersen, Jay R. Unruh, Jeffrey J. Lange, Jennifer L. Gerton, Jin, Jin, Joglekar, Joglekar, Joglekar, Joglekar, Karthik Dhatchinamoorthy, Kim, Kosco, Lampert, Liu, Longtine, Mallavarapu, Malvezzi, Manjunatha Shivaraju, Mayer, McAinsh, McIntosh, McKinney, Meng, Mieck, Miller, Miranda, Ng, Obuse, Pavelka, Pearson, Pfau, Podolski, Powers, Ramey, Sarangapani, Schleiffer, Schmidt, Severin, Shivaraju, Smith, Stephens, Su, Suzuki, Tanaka, Tien, Tytell, Umbreit, Usui, van Breugel, van Hooff, Visintin, Walczak, Wang, Welburn, Westermann, Westermann, Winey, Wisniewski, Wolyniak, Yuen   +90 more
core   +1 more source

The Kinetochore [PDF]

Cold Spring Harbor Perspectives in Biology, 2014
A critical requirement for mitosis is the distribution of genetic material to the two daughter cells. The central player in this process is the macromolecular kinetochore structure, which binds to both chromosomal DNA and spindle microtubule polymers to direct chromosome alignment and segregation. This review will discuss the key kinetochore activities
openaire   +2 more sources

Chromosome Segregation Is Biased by Kinetochore Size [PDF]

, 2018
Chromosome missegregation during mitosis or meiosis is a hallmark of cancer and the main cause of prenatal death in humans. The gain or loss of specific chromosomes is thought to be random, with cell viability being essentially determined by selection ...
Aguiar, P, Almeida, A C, Damas, J, Drpic, D, Khodjakov, A, Larkin, D M, Lewin, H A, Maiato, H, Renda, F   +8 more
core   +1 more source

Reductionism at the vertebrate kinetochore [PDF]

Journal of Cell Biology, 2012
The kinetochore forms the site of attachment for mitotic spindle microtubules driving chromosome segregation. The interdependent protein interactions in this large structure have made it difficult to dissect the function of its components. In this issue, Hori et al. (2013. J. Cell Biol.
Stankovic, Ana, Jansen, Lars E.T.
openaire   +5 more sources

Monopolin subunit Csm1 associates with MIND complex to establish monopolar attachment of sister kinetochores at meiosis I [PDF]

, 2013
Sexually reproducing organisms halve their cellular ploidy during gametogenesis by undergoing a specialized form of cell division known as meiosis. During meiosis, a single round of DNA replication is followed by two rounds of nuclear divisions (referred
A Petrovic, A Toth, AL Marston, AP Joglekar, C Michaelis, C Rumpf, E Screpanti, Eva Hoffmann, GW Kerr, GW Kerr, IL Brito, J Fernius, J Gregan, J Huang, J Matos, J Wong, Jacob Z. Dalgaard, Jonathan B. A. Millar, K Johzuka, K Tada, K Tanaka, KD Corbett, KD Corbett, KP Rabitsch, Louise Newnham, M Petronczki, M Petronczki, MR Przewloka, N Grandin, P Hieter, P Hornung, Prakash Arumugam, Rajesh T. Shenoy, RK Clyne, S Keeney, S Santaguida, S Westermann, SB Buonomo, Sourav Sarkar, Sue Biggins, X Li   +40 more
core   +12 more sources

Balancing the kinetochore ledger [PDF]

Journal of Cell Biology, 2012
Reduction of polo-like kinase-1 (Plk1) at kinetochores as cells progress from prometaphase to metaphase is surprising given that the kinase is thought to stabilize kinetochore–microtubule (kt–MT) attachments. In this issue, Liu et al. (2012. J. Cell Biol.
Thomas J. Maresca, Stuart Cane
openaire   +3 more sources