Results 21 to 30 of about 115,854 (373)

The ultrastructure of the kinetochore and kinetochore fiber in Drosophila somatic cells [PDF]

Chromosoma, 2006
Drosophila melanogaster is a widely used model organism for the molecular dissection of mitosis in animals. However, despite the popularity of this system, no studies have been published on the ultrastructure of Drosophila kinetochores and kinetochore fibers (K-fibers) in somatic cells.
Sara Moutinho-Pereira, Helder Maiato, Kristin J. VandenBeldt, Polla Hergert, Yimin Dong, Bruce F. McEwen, Bruce F. McEwen, Conly L. Rieder, Conly L. Rieder   +8 more
openaire   +4 more sources

Him-10 Is Required for Kinetochore Structure and Function on Caenorhabditis elegans Holocentric Chromosomes [PDF]

, 2001
Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Mary Howe, Kent McDonald, Donna G. Albertson, Barbara J Meyer   +3 more
openalex   +4 more sources

The life and miracles of kinetochores [PDF]

The EMBO Journal, 2009
Kinetochores are large protein assemblies built on chromosomal loci named centromeres. The main functions of kinetochores can be grouped under four modules. The first module, in the inner kinetochore, contributes a sturdy interface with centromeric chromatin. The second module, the outer kinetochore, contributes a microtubule-binding interface.
Santaguida, Stefano, Musacchio, Andrea
openaire   +3 more sources

Assembly principles and stoichiometry of a complete human kinetochore module

Science Advances, 2020
Biochemical reconstitution of human kinetochore delivers complexes with all subunits in the expected stoichiometry. Centromeres are epigenetically determined chromosomal loci that seed kinetochore assembly to promote chromosome segregation during cell ...
K. Walstein, Arsen Petrovic, D. Pan, Birte Hagemeier, Doro Vogt, I. Vetter, A. Musacchio   +6 more
semanticscholar   +1 more source

Hec1/Ndc80 Tail Domain Function at the Kinetochore-Microtubule Interface

Frontiers in Cell and Developmental Biology, 2020
Successful mitotic cell division is critically dependent on the formation of correct attachments between chromosomes and spindle microtubules. Microtubule attachments are mediated by kinetochores, which are large proteinaceous structures assembled on ...
Robert T. Wimbish, J. DeLuca
semanticscholar   +1 more source

Integrating Functions at the Kinetochore [PDF]

Cell, 2002
Kinetochore components have catalytic as well as structural activities. New evidence illustrates how these proteins integrate spindle morphogenesis with regulation of the timing and accuracy of chromosome segregation.
Frank Solomon, Soni L. Shimoda
openaire   +2 more sources

CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes [PDF]

, 2020
Accurate chromosome segregation demands efficient capture of microtubules by kinetochores and their conversion to stable bioriented attachments that can congress and then segregate chromosomes.
Allan, Andrew D. McAinsh, Auckland, Bancroft, Baumbach, Berto, Berto, Bolhy, Bomont, Chan, Ciossani, Currie, DeSantis, Dix, Dudka, Emanuele Roscioli, Etemad, Faulkner, Feng, Filges, Gama, Gassmann, Gutierrez, Haley, Helena Louise Elvidge Coker, Helgeson, Hoffman, Holt, Howell, Huang, Huis In ’t Veld, Johnson, Kanfer, Kanfer, Klinman, Kuhn, Liu, Magidson, Magidson, Maiato, McEwen, McEwen, McKinley, Meraldi, Monda, Moughamian, Musacchio, Musacchio, Musinipally, Olenick, Olziersky, Pandey, Pereira, Peterka, Philip Auckland, Raaijmakers, Ran, Rattner, Rodriguez-Rodriguez, Roscioli, Sacristan, Samejima, Schmidt, Shao, Shrestha, Siller, Simões, Stehman, Tai, Thrower, Toropova, Vagnoni, Vergnolle, Volkov, Wojcik, Wynne, Wynne, Wynne, Yang, Yi, Zhu   +80 more
core   +1 more source

Yeast Fin1-PP1 dephosphorylates an Ipl1 substrate, Ndc80, to remove Bub1-Bub3 checkpoint proteins from the kinetochore during anaphase.

PLoS Genetics, 2021
The spindle assembly checkpoint (SAC) prevents anaphase onset in response to chromosome attachment defects, and SAC silencing is essential for anaphase onset. Following anaphase onset, activated Cdc14 phosphatase dephosphorylates the substrates of cyclin-
Michael Bokros, Delaney Sherwin, Marie-Helene Kabbaj, Yanchang Wang   +3 more
doaj   +1 more source

Tension Management in the Kinetochore [PDF]

Current Biology, 2010
The kinetochore is the protein machine built at the centromere that integrates mechanical force and chemical energy from dynamic microtubules into directed chromosome motion. The kinetochore also provides a powerful signaling function that is able to alter the properties of the spindle checkpoint and initiate a signal transduction cascade that leads to
Elaine Y Yeh, Kerry Bloom
openaire   +3 more sources

Kinetochore structure: electron spectroscopic imaging of the kinetochore. [PDF]

The Journal of cell biology, 1989
The structure of the kinetochore in thin section has been studied in the Indian muntjac by an electron spectroscopic imaging technique. This procedures allows the analysis of the distribution of phosphorus within the layers of the kinetochore. The results indicate that this element is a major component of both the inner and outer plates whereas it is ...
David P. Bazett-Jones, Jerome B. Rattner
openaire   +3 more sources