Results 21 to 30 of about 91,169 (280)
Spatiotemporal dynamics of Spc105 regulates the assembly of the Drosophila kinetochore [PDF]
Open Biology, 2012 The formation of kinetochores shortly before each cell division is a prerequisite for proper chromosome segregation. The synchronous mitoses of Drosophila syncytial embryos have provided an ideal in vivo system to follow kinetochore assembly kinetics and
Zsolt Venkei +7 more
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Tumor Biology, 2017 Spindle and kinetochore–associated protein 1 is a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.
Kai Wang +5 more
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eLife, 2023 At each cell division, nanometer-scale components self-organize to build a micron-scale spindle. In mammalian spindles, microtubule bundles called kinetochore-fibers attach to chromosomes and focus into spindle poles.
Manuela Richter +5 more
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Cell Division: Kinetochores SKAdaddle [PDF]
Current Biology, 2013 Accurate chromosome segregation during cell division requires that kinetochores couple microtubule dynamics to chromosome movement. New research reveals that the kinetochore-associated Ska1 complex hangs on to depolymerizing microtubules and brings some important friends along for the ride.
Ye, Anna A., Maresca, Thomas J.
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Studying Kinetochore Kinases [PDF]
, 2016 Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions.
Saurin, Adrian T., Kops, Geert J. P. L.
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Balancing the kinetochore ledger [PDF]
Journal of Cell Biology, 2012 Reduction of polo-like kinase-1 (Plk1) at kinetochores as cells progress from prometaphase to metaphase is surprising given that the kinase is thought to stabilize kinetochore–microtubule (kt–MT) attachments. In this issue, Liu et al. (2012. J. Cell Biol.
Cane, Stuart, Maresca, Thomas J.
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eLife, 2019 Lagging chromosome is a hallmark of aneuploidy arising from errors in the kinetochore–spindle attachment in animal cells. However, kinetochore components and cellular phenotypes associated with kinetochore dysfunction are much less explored in plants ...
Elena Kozgunova +2 more
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Ybp2 associates with the central kinetochore of Saccharomyces cerevisiae and mediates proper mitotic progression. [PDF]
PLoS ONE, 2008 The spindle checkpoint ensures the accurate segregation of chromosomes by monitoring the status of kinetochore attachment to microtubules. Simultaneous mutations in one of several kinetochore and cohesion genes and a spindle checkpoint gene cause a ...
Kentaro Ohkuni +4 more
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Exploring Plant Meiosis: Insights from the Kinetochore Perspective
Current Issues in Molecular Biology, 2023 The central player for chromosome segregation in both mitosis and meiosis is the macromolecular kinetochore structure, which is assembled by >100 structural and regulatory proteins on centromere DNA.
Kang-Di Zhou +8 more
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Molecular basis of outer kinetochore assembly on CENP-T
eLife, 2016 Stable kinetochore-microtubule attachment is essential for cell division. It requires recruitment of outer kinetochore microtubule binders by centromere proteins C and T (CENP-C and CENP-T).
Pim J Huis in 't Veld +8 more
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