Results 41 to 50 of about 117,673 (373)

Modeling Dual Pathways for the Metazoan Spindle Assembly Checkpoint [PDF]

, 2006
Using computational modelling, we investigate mechanisms of signal transduction focusing on the spindle assembly checkpoint where a single unattached kinetochore is able to signal to prevent cell cycle progression.
Acquaviva, Castro, Clute, De Antoni, DeAntoni, Heinrich, Howell, Kraft, Lang, Luo, M. Howard, Mapelli, McEwen, Musacchio, Nasmyth, Nickell, Northrup, Pan, R. P. Sear, Rieder, Rieder, Rieder, Shah, Sironi, Sudakin, Tang, Tang, Vink, Wojcieszyn, Wollman   +29 more
core   +3 more sources

Synergistic Control of Kinetochore Protein Levels by Psh1 and Ubr2.

PLoS Genetics, 2016
The accurate segregation of chromosomes during cell division is achieved by attachment of chromosomes to the mitotic spindle via the kinetochore, a large multi-protein complex that assembles on centromeres.
Eva Herrero, Peter H Thorpe
doaj   +1 more source

Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA.

PLoS Genetics, 2020
The kinetochore, a multi-protein complex assembled on centromeres, is essential to segregate chromosomes during cell division. Deficiencies in kinetochore function can lead to chromosomal instability and aneuploidy-a hallmark of cancer cells. Kinetochore
Guðjón Ólafsson, Peter H Thorpe
doaj   +1 more source

Budding yeast kinetochore proteins, Chl4 and Ctf19, are required to maintain SPB-centromere proximity during G1 and late anaphase. [PDF]

PLoS ONE, 2014
In the budding yeast, centromeres stay clustered near the spindle pole bodies (SPBs) through most of the cell cycle. This SPB-centromere proximity requires microtubules and functional kinetochores, which are protein complexes formed on the centromeres ...
Soumitra Sau, Sabyasachi Sutradhar, Raja Paul, Pratima Sinha   +3 more
doaj   +1 more source

The COMA complex interacts with Cse4 and positions Sli15/Ipl1 at the budding yeast inner kinetochore

eLife, 2019
Kinetochores are macromolecular protein complexes at centromeres that ensure accurate chromosome segregation by attaching chromosomes to spindle microtubules and integrating safeguard mechanisms.
Josef Fischböck-Halwachs, Sylvia Singh, Mia Potočnjak, Götz Hagemann, Victor Solis-Mezarino, S. Woike, Medini Ghodgaonkar-Steger, Florian Weissmann, Laura D. Gallego, Julie Rojas, J. Andreani, A. Köhler, Franz Herzog   +12 more
semanticscholar   +1 more source

Subcellular Euclidean distance measurements with multicolor fluorescence localization imaging in cultured cells

STAR Protocols, 2021
Summary: This protocol measures the 3D Euclidean distance (Δ3D) between two/three fluorescently labeled kinetochore components in fixed samples using Kinetochore Delta software (KiDv1.0.1, MATLAB based).
Tsvetelina E. Germanova, Emanuele Roscioli, Jonathan U. Harrison, Andrew D. McAinsh, Nigel J. Burroughs   +4 more
doaj   +1 more source

HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes. [PDF]

, 2001
Macromolecular structures called kinetochores attach and move chromosomes within the spindle during chromosome segregation. Using electron microscopy, we identified a structure on the holocentric mitotic and meiotic chromosomes of Caenorhabditis elegans ...
Albertson, Albertson, Albertson, Amon, Buchwitz, Dernburg, Fire, Gonczy, Harlow, Heald, Hedgecock, Hodgkin, Howman, Kainta, Kimble, Lombillo, Maney, McDonald, McEwen, Mello, Moore, Nabetani, Newman, Nicklas, O'Connell, Rappleye, Roos, Savoian, Shah, Sharp, Sharp, Wigge, Yanagida, Yao   +33 more
core   +2 more sources

Spatiotemporal dynamics of Spc105 regulates the assembly of the Drosophila kinetochore [PDF]

Open Biology, 2012
The formation of kinetochores shortly before each cell division is a prerequisite for proper chromosome segregation. The synchronous mitoses of Drosophila syncytial embryos have provided an ideal in vivo system to follow kinetochore assembly kinetics and
Zsolt Venkei, Marcin R. Przewloka, Yaseen Ladak, Shahad Albadri, Alex Sossick, Gabor Juhasz, Béla Novák, David M. Glover   +7 more
doaj   +1 more source

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

bioRxiv, 2019
The kinetochore is a macromolecular structure that assembles on the centromeres of chromosomes and provides the major attachment point for spindle microtubules during mitosis.
Manuel Saldivia, Srinivasa P. S. Rao, E. Fang, E. Myburgh, E. Brown, A. Wollman, Ryan Ritchie, Suresh B Lakhsminarayana, Yen-Liang Chen, Debjani Patra, Hazel X. Y. Koh, Sarah L. Williams, F. Supek, Daniel Paape, Christopher Bower-Lepts, M. Leake, R. McCulloch, M. Kaiser, M. Barrett, Jan Jiricek, T. Diagana, J. Mottram   +21 more
semanticscholar   +1 more source

Prime movers : mechanochemistry of mitotic kinesins [PDF]

, 2014
Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams.
A Blangy, A Groen, A Hutterer, A Jannasch, A Karabay, A Toso, A Yildiz, AA Levesque, AB Asenjo, AC Groen, AE Butterfield, AF Huxley, AF Straight, AJ Roberts, AM Mulder, AM Saunders, Andrew McAinsh, AS Kashina, AS Khalil, B Gigant, B Owens, B Wickstead, BH Kwok, BH Kwok, BJ Grant, BT Schaar, C Antonio, C Hentrich, C Peters, C Thiede, C Wandke, CA Watts, CC Leduc, CE Walczak, CJ Lawrence, CK Hu, CL Parke, CL Rieder, CL Rieder, CM Whitehead, CTC Friel, CV Sindelar, CV Sindelar, D Vanneste, D Vanneste, DA Compton, E Doménech, E Karsenti, E Vladimirou, EG Sturgill, ER Hildebrandt, FJ Kull, FJ Kull, G Fink, GC Rogers, GJ Brouhard, GJ Gorbsky, GJPL Kops, H Aizawa, H Boleti, H Drechsler, H Funabiki, H Yardimci, HS Sardar, HS Sardar, HYK Kaan, I Brust-Mascher, I Brust-Mascher, I Minoura, IM Crevel, IM-TC Crevel, J Espeut, J Helenius, J Roostalu, J Roostalu, J Rosenblatt, J Stumpff, J Stumpff, J Stumpff, J Yajima, JC Cochran, JC Gatlin, JC Waters, JM Scholey, JPI Welburn, JR Aist, JR Cooper, JR McIntosh, JRJ Stout, JS Allingham, JS Weinger, K Hahlen, K Jaqaman, K Kaseda, K Kaseda, K Samejima, KE Gascoigne, KJ Verhey, KS Burbank, KW Wood, KW Wood, KY Lee, L Wordeman, LC Kapitein, LC Kapitein, LN Weaver, LR Sproul, M Braun, M Braun, M Glotzer, M Joshi, M Kikkawa, M Klejnot, M Mishima, M Nishiyama, M Wagenbach, MA Hoyt, MA Seeger, MC Alonso, ME Douglas, ME Tanenbaum, ME Tanenbaum, ME Tanenbaum, MI Mayr, MJ Korneev, ML Gupta, MT Valentine, MT Valentine, N Gudimchuk, N Hirokawa, N Hirokawa, N Joseph, NF Endres, NJ Carter, NJ Ganem, OO Rath, P Bieling, Q Chang, R Nitta, R Nunes Bastos, R Uehara, RB Case, RD Vale, Robert A. Cross, S Acar, S Cai, S Cane, S Debonis, S Diez, S Dumont, S Highsmith, S Inoué, S Oh, S Rice, S Rice, S Shastry, SF Bakhoum, SS Rosenfeld, SS Rosenfeld, SW Grill, T Krzysiak, T Maney, T Surrey, TJ Mitchison, TJ Mitchison, TM Kapoor, TT Ogawa, V Fridman, V Magidson, V Mountain, V Varga, VV Bormuth, W Saunders, WW Wang, X Su, X Su, Y Du, Y Kim, Y Kurasawa, Y Oguchi, Y Zhai, YF Dufrene, YM Lee, YY Okada, Z Yang   +184 more
core   +1 more source