Results 51 to 60 of about 117,673 (373)
Tumor Biology, 2017 Spindle and kinetochore–associated protein 1 is a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation.
Kai Wang +5 more
doaj +1 more source
Kinase and Phosphatase Cross-Talk at the Kinetochore
Front. Cell Dev. Biol., 2018 Multiple kinases and phosphatases act on the kinetochore to control chromosome segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown to regulate both kinetochore-microtubule attachments and the spindle assembly checkpoint.
A. Saurin
semanticscholar +1 more source
Chromosome Oscillations in Mitosis [PDF]
, 2005 Successful cell division requires a tight regulation of chromosome motion via the activity of molecular motors. Many of the key players at the origin of the forces generating the movement have been identified, but their spatial and temporal organization ...
A. P. Joglekar +8 more
core +2 more sources
eLife, 2023 At each cell division, nanometer-scale components self-organize to build a micron-scale spindle. In mammalian spindles, microtubule bundles called kinetochore-fibers attach to chromosomes and focus into spindle poles.
Manuela Richter +5 more
doaj +1 more source
Exotic mitotic mechanisms [PDF]
, 2012 The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Drechsler, Hauke, McAinsh, Andrew D.
core +1 more source
Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments
Biology, 2017 In dividing vertebrate cells multiple microtubules must connect to mitotic kinetochores in a highly stereotypical manner, with each sister kinetochore forming microtubule attachments to only one spindle pole.
M. Lampson, E. Grishchuk
semanticscholar +1 more source
Cell Division: Kinetochores SKAdaddle [PDF]
Current Biology, 2013 Accurate chromosome segregation during cell division requires that kinetochores couple microtubule dynamics to chromosome movement. New research reveals that the kinetochore-associated Ska1 complex hangs on to depolymerizing microtubules and brings some important friends along for the ride.
Ye, Anna A., Maresca, Thomas J.
openaire +2 more sources
Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis [PDF]
, 2010 Sds22 defines protein phosphatase 1 location and function at kinetochores and subsequent activity of aurora B in ...
DeLuca, Jennifer G. +5 more
core +4 more sources
Exploring Plant Meiosis: Insights from the Kinetochore Perspective
Current Issues in Molecular Biology, 2023 The central player for chromosome segregation in both mitosis and meiosis is the macromolecular kinetochore structure, which is assembled by >100 structural and regulatory proteins on centromere DNA.
Kang-Di Zhou +8 more
doaj +1 more source
CDK1-CCNB1 creates a spindle checkpoint–permissive state by enabling MPS1 kinetochore localization
Journal of Cell Biology, 2019 Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase PP2A-B55 regulate the engagement of human MPS1 with unattached kinetochores by ...
D. Hayward +9 more
semanticscholar +1 more source