Results 51 to 60 of about 36,378 (225)

Ybp2 associates with the central kinetochore of Saccharomyces cerevisiae and mediates proper mitotic progression. [PDF]

PLoS ONE, 2008
The spindle checkpoint ensures the accurate segregation of chromosomes by monitoring the status of kinetochore attachment to microtubules. Simultaneous mutations in one of several kinetochore and cohesion genes and a spindle checkpoint gene cause a ...
Kentaro Ohkuni, Rashid Abdulle, Amy Hin Yan Tong, Charles Boone, Katsumi Kitagawa   +4 more
doaj   +1 more source

Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner. [PDF]

, 2019
The spindle assembly checkpoint (SAC) prevents anaphase until all kinetochores attach to the spindle. Each mammalian kinetochore binds many microtubules, but how many attached microtubules are required to turn off the checkpoint, and how the kinetochore ...
Akiyoshi, Alushin, Aravamudhan, Ballister, Barisic, Cane, Cheeseman, Chen, Ciferri, Clute, David, De Antoni, DeLuca, DeLuca, DeLuca, Dick, Dudka, Elting, Elting, Etemad, Etemad, Funabiki, Gassmann, Guimaraes, Hengeveld, Hewitt, Hiruma, Howell, Howell, Hueschen, Janssen, Jelluma, Ji, Johnston, Jonathan Kuhn, Kajtez, Khodjakov, Kuhn, London, Long, Lukinavičius, Maciejowski, Magidson, Maldonado, Maresca, Martin-Lluesma, Matson, McEwen, McIntosh, McKinley, Nijenhuis, Orth, O’Connell, Peterson, Pinsky, Rieder, Rieder, Santaguida, Sarangapani, Saurin, Shah, Sikirzhytski, Sikirzhytski, Sivakumar, Sophie Dumont, Sundin, Suzuki, Suzuki, Tanaka, Tauchman, Uchida, Uetake, Vanoosthuyse, Volkov, Wan, Waters, Wendell, Wojcik, Yoo, Zaytsev, Zaytsev   +80 more
core   +1 more source

The kinetochore uncoiled [PDF]

The Journal of Cell Biology, 2006
Bill Brinkley had first described the kinetochore in the 1960s. He saw, by electron microscopy, a trilaminar, proteinaceous disc structure that flanked the centromere (Brinkley and Stubblefield, 1966). But further details were obscure for another 20 years.
openaire   +2 more sources

Kinetochore protein depletion underlies cytokinesis failure and somatic polyploidization in the moss Physcomitrella patens

eLife, 2019
Lagging chromosome is a hallmark of aneuploidy arising from errors in the kinetochore–spindle attachment in animal cells. However, kinetochore components and cellular phenotypes associated with kinetochore dysfunction are much less explored in plants ...
Elena Kozgunova, Momoko Nishina, Gohta Goshima   +2 more
doaj   +1 more source

Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle

eLife, 2023
At each cell division, nanometer-scale components self-organize to build a micron-scale spindle. In mammalian spindles, microtubule bundles called kinetochore-fibers attach to chromosomes and focus into spindle poles.
Manuela Richter, Lila Neahring, Jinghui Tao, Renaldo Sutanto, Nathan H Cho, Sophie Dumont   +5 more
doaj   +1 more source

Exotic mitotic mechanisms [PDF]

, 2012
The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope.
Drechsler, Hauke, McAinsh, Andrew D.
core   +1 more source

Identification of four unconventional kinetoplastid kinetochore proteins KKT22–25 in Trypanosoma brucei [PDF]

Open Biology, 2019
The kinetochore is a multi-protein complex that drives chromosome segregation in eukaryotes. It assembles onto centromere DNA and interacts with spindle microtubules during mitosis and meiosis. Although most eukaryotes have canonical kinetochore proteins,
Olga O. Nerusheva, Patryk Ludzia, Bungo Akiyoshi   +2 more
doaj   +1 more source

Splicing factors Sf3A2 and Prp31 have direct roles in mitotic chromosome segregation [PDF]

, 2018
Several studies have shown that RNAi-mediated depletion of splicing factors (SFs) results in mitotic abnormalities. However, it is currently unclear whether these abnormalities reflect defective splicing of specific pre-mRNAs or a direct role of the SFs ...
Alushin, Antrobus, Auckland, Beyer, Blower, Blower, Bobkov, Bonaccorsi, Buffin, Burns, Buttrick, Chase, Ciferri, Conduit, De Renzis, DeLuca, DeLuca, Feijão, Giansanti, Giansanti, Giansanti, Giet, Goshima, Goto, Grenfell, Grenfell, Guilgur, Hanisch, Harel, Hayward, Heeger, Helgeson, Herold, Hofmann, Hofmann, Huranová, Janczyk, Khodor, Kiseleva, Kittler, Lehner, Liu, Maslon, Montembault, Neumann, Nguyen, Pacheco, Peretz, Przewloka, Raffa, Renda, Rogers, Roscioli, Rošić, Schittenhelm, Schweizer, Sharp, Shin, Silljé, Somma, Somma, Sundaramoorthy, Tadros, Takenaka, Tanenbaum, Toso, van der Lelij, Varma, Venkei, Vernì, Walker, Williams, Williams, Wu, Zalokar   +74 more
core   +1 more source

The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubule. [PDF]

, 2011
There has been much effort in recent years aimed at understanding the molecular mechanism by which the Dam1 kinetochore complex is able to couple microtubule depolymerization to poleward movement. Both a biased diffusion and a forced walk model have been
Barnes, Georjana, Drubin, David, Liu, Jian, Nakajima, Yuko, Nogales, Eva, Ramey, Vincent H, Wang, Hong-Wei, Wong, Amanda   +7 more
core   +2 more sources

Poleward force at the kinetochore in metaphase depends on the number of kinetochore microtubules. [PDF]

The Journal of cell biology, 1990
To examine the dependence of poleward force at a kinetochore on the number of kinetochore microtubules (kMTs), we altered the normal balance in the number of microtubules at opposing homologous kinetochores in meiosis I grasshopper spermatocytes at metaphase with a focused laser microbeam.
Thomas S. Hays, Edward D. Salmon
openaire   +3 more sources