Results 61 to 70 of about 115,854 (373)

A TOGgle for Tension at Kinetochores [PDF]

Cell, 2016
Differential stability of kinetochore-microtubule attachments at low versus high tension is critical for accurate chromosome segregation. Miller et al. find that a TOG domain microtubule-binding protein imparts intrinsic tension selectivity to kinetochore-microtubule attachments.
Bram Prevo, Bram Prevo, Dhanya K. Cheerambathur, Dhanya K. Cheerambathur, Arshad Desai, Arshad Desai   +5 more
openaire   +3 more sources

Adventures of the undead at kinetochores [PDF]

Molecular & Cellular Oncology, 2021
At the metaphase-to-anaphase transition, phosphatase activity feeds back to reverse early mitotic phosphorylation events. Our recent work indicates that the pseudokinase domain of the spindle checkpoint protein BUB1 (Budding Uninhibited by Benzimidazoles 1) mitotic checkpoint serine/threonine kinase B (BUB1B, BUBR1) maintains kinase-phosphatase balance
openaire   +4 more sources

Prime movers : mechanochemistry of mitotic kinesins [PDF]

, 2014
Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams.
A Blangy, A Groen, A Hutterer, A Jannasch, A Karabay, A Toso, A Yildiz, AA Levesque, AB Asenjo, AC Groen, AE Butterfield, AF Huxley, AF Straight, AJ Roberts, AM Mulder, AM Saunders, Andrew McAinsh, AS Kashina, AS Khalil, B Gigant, B Owens, B Wickstead, BH Kwok, BH Kwok, BJ Grant, BT Schaar, C Antonio, C Hentrich, C Peters, C Thiede, C Wandke, CA Watts, CC Leduc, CE Walczak, CJ Lawrence, CK Hu, CL Parke, CL Rieder, CL Rieder, CM Whitehead, CTC Friel, CV Sindelar, CV Sindelar, D Vanneste, D Vanneste, DA Compton, E Doménech, E Karsenti, E Vladimirou, EG Sturgill, ER Hildebrandt, FJ Kull, FJ Kull, G Fink, GC Rogers, GJ Brouhard, GJ Gorbsky, GJPL Kops, H Aizawa, H Boleti, H Drechsler, H Funabiki, H Yardimci, HS Sardar, HS Sardar, HYK Kaan, I Brust-Mascher, I Brust-Mascher, I Minoura, IM Crevel, IM-TC Crevel, J Espeut, J Helenius, J Roostalu, J Roostalu, J Rosenblatt, J Stumpff, J Stumpff, J Stumpff, J Yajima, JC Cochran, JC Gatlin, JC Waters, JM Scholey, JPI Welburn, JR Aist, JR Cooper, JR McIntosh, JRJ Stout, JS Allingham, JS Weinger, K Hahlen, K Jaqaman, K Kaseda, K Kaseda, K Samejima, KE Gascoigne, KJ Verhey, KS Burbank, KW Wood, KW Wood, KY Lee, L Wordeman, LC Kapitein, LC Kapitein, LN Weaver, LR Sproul, M Braun, M Braun, M Glotzer, M Joshi, M Kikkawa, M Klejnot, M Mishima, M Nishiyama, M Wagenbach, MA Hoyt, MA Seeger, MC Alonso, ME Douglas, ME Tanenbaum, ME Tanenbaum, ME Tanenbaum, MI Mayr, MJ Korneev, ML Gupta, MT Valentine, MT Valentine, N Gudimchuk, N Hirokawa, N Hirokawa, N Joseph, NF Endres, NJ Carter, NJ Ganem, OO Rath, P Bieling, Q Chang, R Nitta, R Nunes Bastos, R Uehara, RB Case, RD Vale, Robert A. Cross, S Acar, S Cai, S Cane, S Debonis, S Diez, S Dumont, S Highsmith, S Inoué, S Oh, S Rice, S Rice, S Shastry, SF Bakhoum, SS Rosenfeld, SS Rosenfeld, SW Grill, T Krzysiak, T Maney, T Surrey, TJ Mitchison, TJ Mitchison, TM Kapoor, TT Ogawa, V Fridman, V Magidson, V Mountain, V Varga, VV Bormuth, W Saunders, WW Wang, X Su, X Su, Y Du, Y Kim, Y Kurasawa, Y Oguchi, Y Zhai, YF Dufrene, YM Lee, YY Okada, Z Yang   +184 more
core   +1 more source

Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle

eLife, 2023
At each cell division, nanometer-scale components self-organize to build a micron-scale spindle. In mammalian spindles, microtubule bundles called kinetochore-fibers attach to chromosomes and focus into spindle poles.
Manuela Richter, Lila Neahring, Jinghui Tao, Renaldo Sutanto, Nathan H Cho, Sophie Dumont   +5 more
doaj   +1 more source

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

bioRxiv, 2019
The kinetochore is a macromolecular structure that assembles on the centromeres of chromosomes and provides the major attachment point for spindle microtubules during mitosis.
Manuel Saldivia, Srinivasa P. S. Rao, E. Fang, E. Myburgh, E. Brown, A. Wollman, Ryan Ritchie, Suresh B Lakhsminarayana, Yen-Liang Chen, Debjani Patra, Hazel X. Y. Koh, Sarah L. Williams, F. Supek, Daniel Paape, Christopher Bower-Lepts, M. Leake, R. McCulloch, M. Kaiser, M. Barrett, Jan Jiricek, T. Diagana, J. Mottram   +21 more
semanticscholar   +1 more source

The kinetochore uncoiled [PDF]

The Journal of Cell Biology, 2006
Bill Brinkley had first described the kinetochore in the 1960s. He saw, by electron microscopy, a trilaminar, proteinaceous disc structure that flanked the centromere (Brinkley and Stubblefield, 1966). But further details were obscure for another 20 years.
openaire   +2 more sources

Bod1, a novel kinetochore protein required for chromosome biorientation [PDF]

, 2007
We have combined the proteomic analysis of Xenopus laevis in vitro–assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. The first of these is Bod1, a protein
Andersen, Jens S., Blow, J. Julian, Hunter, Christopher J., Khoudoli, Guennadi A., McAinsh, Andrew D., McClelland, Sarah E., Porter, Iain M., Swedlow, Jason R.   +7 more
core   +4 more sources

CDK1-CCNB1 creates a spindle checkpoint–permissive state by enabling MPS1 kinetochore localization

Journal of Cell Biology, 2019
Spindle checkpoint signaling is initiated by recruitment of the kinase MPS1 to unattached kinetochores during mitosis. We show that CDK1-CCNB1 and a counteracting phosphatase PP2A-B55 regulate the engagement of human MPS1 with unattached kinetochores by ...
D. Hayward, Tatiana Alfonso-Pérez, M. J. Cundell, Michael Hopkins, James Holder, James M. Bancroft, Lukas H Hutter, B. Novák, F. Barr, U. Gruneberg   +9 more
semanticscholar   +1 more source

Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]

, 2014
The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
core   +2 more sources

CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization

Journal of Cell Biology, 2019
Kinetochore localization of CENP-C, which is a key and conserved kinetochore component, is regulated during cell cycle progression. Watanabe et al. demonstrate that CDK1-mediated CENP-C phosphorylation regulates mitotic kinetochore localization via ...
Reito Watanabe, Masatoshi Hara, E. Okumura, Solène Hervé, D. Fachinetti, M. Ariyoshi, T. Fukagawa   +6 more
semanticscholar   +1 more source