Results 61 to 70 of about 40,318 (318)
PLoS Genetics, 2019 The kinetochore is the central molecular machine that drives chromosome segregation in all eukaryotes. Genetic studies have suggested that protein sumoylation plays a role in regulating the inner kinetochore; however, the mechanism remains elusive. Here,
Raymond T Suhandynata +5 more
doaj +1 more source
Molecular basis of outer kinetochore assembly on CENP-T
eLife, 2016 Stable kinetochore-microtubule attachment is essential for cell division. It requires recruitment of outer kinetochore microtubule binders by centromere proteins C and T (CENP-C and CENP-T).
Pim J Huis in 't Veld +8 more
doaj +1 more source
Checkpoint proteins come under scrutiny [PDF]
, 2013 Details are emerging of the interactions between the kinetochore and various spindle checkpoint proteins that ensure that sister chromatids are equally divided between daughter cells during cell ...
Millar, Jonathan B. A. +1 more
core +1 more source
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. [PDF]
, 2015 The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset.
Bhalla, Needhi +3 more
core +1 more source
Advanced Science, EarlyView.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +9 more
wiley +1 more source
Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa
Advanced Science, EarlyView.Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang +13 more
wiley +1 more source
Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores
Cells, 2019 Faithful chromosome segregation during mitosis is crucial for maintaining genome stability. The spindle assembly checkpoint (SAC) is a surveillance mechanism that ensures accurate mitotic progression.
Zhen Dou +5 more
doaj +1 more source
Identification of four unconventional kinetoplastid kinetochore proteins KKT22–25 in Trypanosoma brucei [PDF]
Open Biology, 2019 The kinetochore is a multi-protein complex that drives chromosome segregation in eukaryotes. It assembles onto centromere DNA and interacts with spindle microtubules during mitosis and meiosis. Although most eukaryotes have canonical kinetochore proteins,
Olga O. Nerusheva +2 more
doaj +1 more source
Kinetochore inactivation by expression of a repressive mRNA. [PDF]
, 2017 Differentiation programs such as meiosis depend on extensive gene regulation to mediate cellular morphogenesis. Meiosis requires transient removal of the outer kinetochore, the complex that connects microtubules to chromosomes.
Chen, Jingxun +8 more
core +2 more sources