Results 71 to 80 of about 115,854 (373)
The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubule. [PDF]
, 2011 There has been much effort in recent years aimed at understanding the molecular mechanism by which the Dam1 kinetochore complex is able to couple microtubule depolymerization to poleward movement. Both a biased diffusion and a forced walk model have been
Barnes, Georjana +7 more
core +2 more sources
Ybp2 associates with the central kinetochore of Saccharomyces cerevisiae and mediates proper mitotic progression. [PDF]
PLoS ONE, 2008 The spindle checkpoint ensures the accurate segregation of chromosomes by monitoring the status of kinetochore attachment to microtubules. Simultaneous mutations in one of several kinetochore and cohesion genes and a spindle checkpoint gene cause a ...
Kentaro Ohkuni +4 more
doaj +1 more source
Nature Communications, 2019 Proper chromosome segregation depends upon kinetochore phosphorylation by the Chromosome Passenger Complex (CPC). Current models suggest the activity of the CPC decreases in response to the inter-kinetochore stretch that accompanies the formation of bi ...
Prasad D. Trivedi +7 more
semanticscholar +1 more source
TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. [PDF]
, 2015 The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset.
Bhalla, Needhi +3 more
core +1 more source
eLife, 2019 Lagging chromosome is a hallmark of aneuploidy arising from errors in the kinetochore–spindle attachment in animal cells. However, kinetochore components and cellular phenotypes associated with kinetochore dysfunction are much less explored in plants ...
Elena Kozgunova +2 more
doaj +1 more source
Studying Kinetochore Kinases [PDF]
, 2016 Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions.
Geert J. P. L. Kops +2 more
openaire +4 more sources
How to halve ploidy : lessons from budding yeast meiosis [PDF]
, 2012 Maintenance of ploidy in sexually reproducing organisms requires a specialized form of cell division called meiosis that generates genetically diverse haploid gametes from diploid germ cells.
Arumugam, Prakash +2 more
core +1 more source
Exploring Plant Meiosis: Insights from the Kinetochore Perspective
Current Issues in Molecular Biology, 2023 The central player for chromosome segregation in both mitosis and meiosis is the macromolecular kinetochore structure, which is assembled by >100 structural and regulatory proteins on centromere DNA.
Kang-Di Zhou +8 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Microtubules are dynamic, tube-like structures that drive the segregation of duplicated chromosomes during cell division. The Ska complex is part of a molecular machine that forms force-bearing connections between chromosomes and microtubule
Luke A. Helgeson +5 more
semanticscholar +1 more source
Division of labour between PP2A-B56 isoforms at the centromere and kinetochore
eLife, 2019 PP2A-B56 is a serine/threonine phosphatase complex that regulates several major mitotic processes, including sister chromatid cohesion, kinetochore-microtubule attachment and the spindle assembly checkpoint.
Giulia Vallardi +3 more
semanticscholar +1 more source