Results 71 to 80 of about 36,378 (225)
Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]
, 2014 Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Amalie E. Dick +36 more
core +1 more source
Conservation of centromeric histone 3 interaction partners in plants [PDF]
, 2020 The loading and maintenance of centromeric histone 3 (CENH3) at the centromere are critical processes ensuring appropriate kinetochore establishment and equivalent segregation of the homologous chromosomes during cell division.
Geelen, Danny +3 more
core +1 more source
Discovery of Unconventional Kinetochores in Kinetoplastids [PDF]
Cell, 2014 The kinetochore is the macromolecular protein complex that directs chromosome segregation in eukaryotes. It has been widely assumed that the core kinetochore consists of proteins that are common to all eukaryotes. However, no conventional kinetochore components have been identified in any kinetoplastid genome, thus challenging this assumption of ...
Akiyoshi, B, Gull, K
openaire +4 more sources
Latrunculin A delays anaphase onset in fission yeast by disrupting an ase1-independent pathway controlling mitotic spindle stability [PDF]
, 2008 It has been proposed previously that latrunculin A, an inhibitor of actin polymerization, delays the onset of anaphase by causing spindle misorientation in fission yeast.
Meadows, John C., Millar, Jonathan B. A.
core +2 more sources
The Journal of Cell Biology, 2006 ![][1] Overproduced CENP-A (green) induces an ectopic kinetochore (blue) with attached microtubule (red). KARPEN/ELSEVIER Extra functional kinetochores can be created by overexpressing just a single protein, according to Patrick Heun, Sylvia Erhardt, Gary Karpen (University ...
openaire +3 more sources
A novel chromosome segregation mechanism during female meiosis. [PDF]
, 2016 In a wide range of eukaryotes, chromosome segregation occurs through anaphase A, in which chromosomes move toward stationary spindle poles, anaphase B, in which chromosomes move at the same velocity as outwardly moving spindle poles, or both. In contrast,
Cortes, Daniel B +4 more
core +1 more source
Kinetochore or Centromere? [PDF]
Nature, 1939 IN his recent communication1, Dr. Mather seems to have no argument against the applicability of ‘kinetochore’. He sponsors “centromere” largely because it is used by a number of investigators. But I, for one, am not convinced that it is the “best term in use to-day”. To Dr. Mather ‘centromere’ may imply a visible particle, but to many it will connote a
openaire +1 more source
Studying Kinetochore Kinases [PDF]
, 2016 Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions.
Geert J. P. L. Kops +2 more
openaire +3 more sources
Human Shugoshin Mediates Kinetochore-Driven Formation of Kinetochore Microtubules [PDF]
Cell Cycle, 2006 The conserved protein Shugoshin (Sgo) plays a role in the maintenance of centromeric cohesion in mitosis and meiosis. Human Shugoshin (hSgo) was first identified as an overexpressed protein in breast cancers. Here we demonstrate that hSgo mediates kinetochore-driven formation of kinetochore -microtubules (MTs) during bipolar spindle assembly.
Megumi Tsuji +5 more
openaire +3 more sources
Ordered Kinetochore Assembly in the Human-Pathogenic Basidiomycetous Yeast
mBio, 2013 Kinetochores facilitate interaction between chromosomes and the spindle apparatus. The formation of a metazoan trilayered kinetochore is an ordered event in which inner, middle, and outer layers assemble during disassembly of the nuclear envelope during ...
Lukasz Kozubowski +8 more
doaj +1 more source