Results 71 to 80 of about 105,405 (279)

Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores

Cells, 2019
Faithful chromosome segregation during mitosis is crucial for maintaining genome stability. The spindle assembly checkpoint (SAC) is a surveillance mechanism that ensures accurate mitotic progression.
Zhen Dou, Diogjena Katerina Prifti, Ping Gui, Xing Liu, Sabine Elowe, Xuebiao Yao   +5 more
doaj   +1 more source

Molecular mechanisms facilitating the initial kinetochore encounter with spindle microtubules [PDF]

, 2017
The initial kinetochore encounter with a spindle microtubule (kinetochore capture) is one of the rate-limiting steps in establishing proper kinetochore–microtubule interaction during mitosis. Kinetochore capture is facilitated by multiple factors such as
Al-Bassam, Amberg, Athale, Bressan, Brun, Carazo-Salas, Cheerambathur, Clarke, Etsushi Kitamura, Fu, Gandhi, Gonen, Haruki, Hill, Janke, Kalinina, Kaláb, Kerppola, Khodjakov, Kirschner, Kitamura, Kitamura, Knop, Lim, Long, Ma, Maekawa, Maffini, Maiato, Marek Gierlinski, Maure, Michaelis, Miller, Natsume, Nicola O’Reilly, Nishimura, Ortiz, O’Reilly, Pasqualone, Peset, Richmond, Rieder, Shrestha, Straight, Straight, Sullivan, Sung, Tanaka, Tanaka, Tanaka, Tanaka, Tanaka, Tanaka, Tomoyuki U. Tanaka, Uhlmann, Vanya Vasileva, Wieczorek, Winey, Wollman, Yabuki, Yin, Zuojun Yue   +61 more
core   +2 more sources

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

Advanced Science, EarlyView.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho, Jee Won Hwang, Gyu Hwan Hyun, Sangkyu Lee, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim   +6 more
wiley   +1 more source

Importin-beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function [PDF]

, 2017
Protein conjugation with small ubiquitin-related modifier (SUMO) is a post-translational modification that modulates protein interactions and localisation.
Damizia, Michela, DE SANTIS, RICCARDO, DE TURRIS, VALERIA, GILISTRO, EUGENIA, Lavia, Patrizia, MORONI, SARA, ROSA, ALESSANDRO, VERRICO, ANNALISA   +7 more
core   +1 more source

ZSL Orchestrates Synaptonemal Complex Assembly as a Central Region Scaffold to Ensure Synapsis Fidelity and Crossover Control in Polyploid Meiosis

Advanced Science, EarlyView.
A central molecular adaptor, ZSL, is identified that links transverse filaments ZYP1 to central element SCEP1/2 to drive synaptonemal complex assembly in Brassica napus. Loss of ZSL abolishes synaptonemal complex formation, disrupts meiotic chromosome segregation, and markedly increases crossovers, providing mechanistic insight into meiotic fidelity ...
Miaowei Geng, Shaochen Jia, Fei Cao, Cuiping Liu, Heshuang Zhang, Gang Xu, Jixin Zhuang, Yashi Zhang, Can Liu, Yuhang Zhao, Zilin Guo, Xinjie Yuan, Jiaqing Yang, Lei Chu, Bowei Cai, Hu Zhao, Chao Yang   +16 more
wiley   +1 more source

Recent advances in plant kinetochore research

Frontiers in Cell and Developmental Biology
Faithful chromosome segregation is crucial for cell division in eukaryotes, facilitated by the kinetochore, a multi-subunit protein complex that connects chromosomes to the spindle microtubules.
Elena Kozgunova, Elena Kozgunova
doaj   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Plant kinetochore complex: composition, function, and regulation

Frontiers in Plant Science
The kinetochore complex, an important protein assembly situated on the centromere, plays a pivotal role in chromosome segregation during cell division.
Yuqian Xie, Mingliang Wang, Beixin Mo, Beixin Mo, Chao Liang, Chao Liang   +5 more
doaj   +1 more source

Ordered Kinetochore Assembly in the Human-Pathogenic Basidiomycetous Yeast Cryptococcus neoformans

mBio, 2013
Kinetochores facilitate interaction between chromosomes and the spindle apparatus. The formation of a metazoan trilayered kinetochore is an ordered event in which inner, middle, and outer layers assemble during disassembly of the nuclear envelope during ...
Lukasz Kozubowski, Vikas Yadav, Gautam Chatterjee, Shreyas Sridhar, Masashi Yamaguchi, Susumu Kawamoto, Indrani Bose, Joseph Heitman, Kaustuv Sanyal   +8 more
doaj   +1 more source

One-two punch mechanism of gene repression: a fresh perspective on gene regulation. [PDF]

, 2017
Cellular differentiation depends on temporally controlled waves of gene activation and inactivation that ultimately transform one cell type into another.
Tresenrider, Amy, Ünal, Elçin
core   +1 more source