Results 81 to 90 of about 115,854 (373)

Poleward force at the kinetochore in metaphase depends on the number of kinetochore microtubules. [PDF]

The Journal of cell biology, 1990
To examine the dependence of poleward force at a kinetochore on the number of kinetochore microtubules (kMTs), we altered the normal balance in the number of microtubules at opposing homologous kinetochores in meiosis I grasshopper spermatocytes at metaphase with a focused laser microbeam.
Thomas S. Hays, Edward D. Salmon
openaire   +3 more sources

The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation [PDF]

, 2015
Unlike other organisms that have evolved distinct H2A variants for different functions, Drosophila melanogaster has just one variant which is capable of filling many roles.
Cenci, Giovanni, Verni', Fiammetta
core   +1 more source

Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore–microtubule dynamics

Journal of Cell Biology, 2018
Precise regulation of kinetochore–microtubule attachments is essential for successful chromosome segregation. Central to this regulation is Aurora B kinase, which phosphorylates kinetochore substrates to promote microtubule turnover. A critical target of
Keith F. DeLuca, A. Meppelink, A. Broad, J. Mick, O. Peersen, Sibel Pektaş, S. Lens, J. DeLuca   +7 more
semanticscholar   +1 more source

A Rho for the kinetochore

The Journal of Cell Biology, 2004
![Graphic][1] Chromosome alignment on the spindle (top) is lost if Cdc42 is inactivated (bottom). Narumiya/Macmillan Results from Shingo Yasuda, Shuh Narumiya (Kyoto University, Kyoto, Japan), and colleagues reveal microtubules at the cell cortex, are also needed for microtubule–
openaire   +3 more sources

Discovery of Unconventional Kinetochores in Kinetoplastids [PDF]

Cell, 2014
The kinetochore is the macromolecular protein complex that directs chromosome segregation in eukaryotes. It has been widely assumed that the core kinetochore consists of proteins that are common to all eukaryotes. However, no conventional kinetochore components have been identified in any kinetoplastid genome, thus challenging this assumption of ...
Akiyoshi, B, Gull, K
openaire   +4 more sources

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis [PDF]

, 2007
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors.
Clarke, Alan, Dikovskaya, Dina, Jamieson, Thomas J., Kroboth, Karin, Meniel, Valerie, Nathke, Inke S., Newton, Ian P., Oakley, Abigail, Sansom, Owen, Schiffmann, David   +9 more
core   +5 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Identification of four unconventional kinetoplastid kinetochore proteins KKT22–25 in Trypanosoma brucei [PDF]

Open Biology, 2019
The kinetochore is a multi-protein complex that drives chromosome segregation in eukaryotes. It assembles onto centromere DNA and interacts with spindle microtubules during mitosis and meiosis. Although most eukaryotes have canonical kinetochore proteins,
Olga O. Nerusheva, Patryk Ludzia, Bungo Akiyoshi   +2 more
doaj   +1 more source

Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments

Biology, 2017
In dividing vertebrate cells multiple microtubules must connect to mitotic kinetochores in a highly stereotypical manner, with each sister kinetochore forming microtubule attachments to only one spindle pole.
M. Lampson, E. Grishchuk
semanticscholar   +1 more source

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source