Results 81 to 90 of about 40,318 (318)
Advanced Science, EarlyView.The waterlogging tolerance of allotetraploid Actinidia valvata is inherited from one of its diploid progenitors, which leads to subgenome expression dominance, mediated by complex mechanisms including altered chromatin accessibility and DNA methylation.
Xiaoli Hu +14 more
wiley +1 more source
The Journal of Cell Biology, 2006 ![][1] Overproduced CENP-A (green) induces an ectopic kinetochore (blue) with attached microtubule (red). KARPEN/ELSEVIER Extra functional kinetochores can be created by overexpressing just a single protein, according to Patrick Heun, Sylvia Erhardt, Gary Karpen (University ...
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Kinetochore or Centromere? [PDF]
Nature, 1939 IN his recent communication1, Dr. Mather seems to have no argument against the applicability of ‘kinetochore’. He sponsors “centromere” largely because it is used by a number of investigators. But I, for one, am not convinced that it is the “best term in use to-day”. To Dr. Mather ‘centromere’ may imply a visible particle, but to many it will connote a
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Plant kinetochore complex: composition, function, and regulation
Frontiers in Plant ScienceThe kinetochore complex, an important protein assembly situated on the centromere, plays a pivotal role in chromosome segregation during cell division.
Yuqian Xie +5 more
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Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]
, 2014 The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
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Human Shugoshin Mediates Kinetochore-Driven Formation of Kinetochore Microtubules [PDF]
Cell Cycle, 2006 The conserved protein Shugoshin (Sgo) plays a role in the maintenance of centromeric cohesion in mitosis and meiosis. Human Shugoshin (hSgo) was first identified as an overexpressed protein in breast cancers. Here we demonstrate that hSgo mediates kinetochore-driven formation of kinetochore -microtubules (MTs) during bipolar spindle assembly.
Megumi Tsuji +5 more
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Long‐Read Whole‐Genome Sequencing Uncovers a Deletion Upstream to HOXD13 Causing Synpolydactyly
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Synpolydactyly (SPD) is a heterogeneous distal‐limb malformation syndrome, characterized by webbing and duplication of adjacent digits. SPD1, the most common type, is attributed to disease‐causing variants in HOXD13, a transcription factor in the HOXD cluster that is essential for limb development. Here, we present a challenging exome‐negative
Jonathan Rips +9 more
wiley +1 more source
Ordered Kinetochore Assembly in the Human-Pathogenic Basidiomycetous Yeast
mBio, 2013 Kinetochores facilitate interaction between chromosomes and the spindle apparatus. The formation of a metazoan trilayered kinetochore is an ordered event in which inner, middle, and outer layers assemble during disassembly of the nuclear envelope during ...
Lukasz Kozubowski +8 more
doaj +1 more source
SWAP, SWITCH, and STABILIZE: Mechanisms of Kinetochore–Microtubule Error Correction
Cells, 2022 For correct chromosome segregation in mitosis, eukaryotic cells must establish chromosome biorientation where sister kinetochores attach to microtubules extending from opposite spindle poles.
Tomoyuki U. Tanaka, Tongli Zhang
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In Vitro Kinetochore Assembly [PDF]
, 2016 The kinetochore is the primary site of interaction between chromosomes and microtubules of the mitotic spindle during chromosome segregation. Kinetochores are composed of more than 100 proteins that transiently assemble during mitosis at a single epigenetically defined region on each chromosome, known as the centromere.
Aaron F. Straight, Matthew D. D. Miell
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