Results 81 to 90 of about 117,673 (373)

Human Ska complex and Ndc80 complex interact to form a load-bearing assembly that strengthens kinetochore–microtubule attachments

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Microtubules are dynamic, tube-like structures that drive the segregation of duplicated chromosomes during cell division. The Ska complex is part of a molecular machine that forms force-bearing connections between chromosomes and microtubule
Luke A. Helgeson, A. Zelter, Michael Riffle, M. MacCoss, C. Asbury, T. Davis   +5 more
semanticscholar   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Quantitative Analysis of Kinetochore Protein Levels and Inter-Kinetochore Distances in Mammalian Cells During Mitosis

Bio-Protocol
The mammalian kinetochore is a multi-layered protein complex that forms on the centromeric chromatin. The kinetochore serves as the attachment hub for the plus ends of microtubules emanating from the centrosomes during mitosis.
Neeraj Wasnik, Mahima Singhal, Sukirti Khantwal, Sanghamitra Mylavarapu, Sivaram Mylavarapu   +4 more
doaj   +1 more source

Recent Progress on the Localization of the Spindle Assembly Checkpoint Machinery to Kinetochores

Cells, 2019
Faithful chromosome segregation during mitosis is crucial for maintaining genome stability. The spindle assembly checkpoint (SAC) is a surveillance mechanism that ensures accurate mitotic progression.
Zhen Dou, Diogjena Katerina Prifti, Ping Gui, Xing Liu, Sabine Elowe, Xuebiao Yao   +5 more
doaj   +1 more source

Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore–microtubule dynamics

Journal of Cell Biology, 2018
Precise regulation of kinetochore–microtubule attachments is essential for successful chromosome segregation. Central to this regulation is Aurora B kinase, which phosphorylates kinetochore substrates to promote microtubule turnover. A critical target of
Keith F. DeLuca, A. Meppelink, A. Broad, Jeanne E. Mick, O. Peersen, Sibel Pektaş, S. Lens, J. DeLuca   +7 more
semanticscholar   +1 more source

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis [PDF]

, 2007
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors.
Clarke, Alan, Dikovskaya, Dina, Jamieson, Thomas J., Kroboth, Karin, Meniel, Valerie, Nathke, Inke S., Newton, Ian P., Oakley, Abigail, Sansom, Owen, Schiffmann, David   +9 more
core   +5 more sources

LOXHD1 and RHOB Expression by Monocytes Predicts Progressive Systemic Sclerosis associated Interstitial Lung Disease

Arthritis Care &Research, Accepted Article.
Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla, Robert Lafyatis, Kevin F Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J Kass   +13 more
wiley   +1 more source

Enrichment of Aurora B kinase at the inner kinetochore controls outer kinetochore assembly

Journal of Cell Biology, 2019
In mitosis, the outer kinetochore is assembled to signal the spindle assembly checkpoint and to attach chromosomes to spindle microtubules. Bonner et al.
Mary Kate Bonner, Julian Haase, Jason Swinderman, Hyunmi K. Halas, L. M. Miller Jenkins, Alexander E. Kelly   +5 more
semanticscholar   +1 more source

Molecular mechanisms facilitating the initial kinetochore encounter with spindle microtubules [PDF]

, 2017
The initial kinetochore encounter with a spindle microtubule (kinetochore capture) is one of the rate-limiting steps in establishing proper kinetochore–microtubule interaction during mitosis. Kinetochore capture is facilitated by multiple factors such as
Al-Bassam, Amberg, Athale, Bressan, Brun, Carazo-Salas, Cheerambathur, Clarke, Etsushi Kitamura, Fu, Gandhi, Gonen, Haruki, Hill, Janke, Kalinina, Kaláb, Kerppola, Khodjakov, Kirschner, Kitamura, Kitamura, Knop, Lim, Long, Ma, Maekawa, Maffini, Maiato, Marek Gierlinski, Maure, Michaelis, Miller, Natsume, Nicola O’Reilly, Nishimura, Ortiz, O’Reilly, Pasqualone, Peset, Richmond, Rieder, Shrestha, Straight, Straight, Sullivan, Sung, Tanaka, Tanaka, Tanaka, Tanaka, Tanaka, Tanaka, Tomoyuki U. Tanaka, Uhlmann, Vanya Vasileva, Wieczorek, Winey, Wollman, Yabuki, Yin, Zuojun Yue   +61 more
core   +2 more sources

MYCOPHENOLATE MOFETIL TREATMENT REDUCES THE RISK OF TREATMENT ESCALATION DUE TO VASCULAR COMPLICATIONS IN LIMITED CUTANEOUS SYSTEMIC SCLEROSIS: EMULATION OF A TARGET TRIAL FROM ITALIAN RHEUMATOLOGY SOCIETY SPRING REGISTRY

Arthritis Care &Research, Accepted Article.
Objective Mycophenolate Mofetil (MMF) use in limited cutaneous systemic sclerosis (lcSSc) is relatively uncommon due to the lower fibrotic burden and the predominance of the vascular complications. In vitro observations and clinical data from transplanted patients suggest a protective effect of MMF on endothelial function.
Enrico De Lorenzis, Gerlando Natalello, Rossella De Angelis, Lucrezia Verardi, Dilia Giuggioli, Gianluigi Bajocchi, Lorenzo Dagna, Silvia Bellando‐Randone, Giovanni Zanframundo, Rosario Foti, Fabio Cacciapaglia, Giovanna Cuomo, Alarico Ariani, Edoardo Rosato, Gemma Lepri, Francesco Girelli, Valeria Riccieri, Elisabetta Zanatta, Ilaria Cavazzana, Francesca Ingegnoli, Maria De Santis, Giuseppe Murdaca, Giuseppina Abignano, Giorgio Pettiti, Alessandra Della Rossa, Maurizio Caminiti, Annamaria Iuliano, Giovanni Ciano, Lorenzo Beretta, Gianluca Bagnato, Ennio Lubrano, Maria Ilenia De Andres, Alessandro Giollo, Cosimo Bruni, Martina Orlandi, Marco Fornaro, Marta Saracco, Cecilia Agnes, Pier Giacomo Cerasuolo, Gabriella Alonzi, Edoardo Cipolletta, Federica Lumetti, Amelia Spinella, Luca Magnani, Corrado Campochiaro, Giacomo De Luca, Veronica Codullo, Elisa Visalli, Carlo Iandoli, Antonietta Gigante, Greta Pellegrino, Erika Pigatto, Maria‐Grazia Lazzaroni, Franco Franceschini, Elena Generali, Gianna Mennillo, Simone Barsotti, Giuseppa Pagano Mariano, Federica Furini, Licia Vultaggio, Simone Parisi, Clara Lisa Peroni, Gerolamo Bianchi, Enrico Fusaro, Gian Domenico Sebastiani, Marcello Govoni, Salvatore D'Angelo, Franco Cozzi, Fabrizio Conti, Serena Guiducci, Andrea Doria, Carlo Salvarani, Florenzo Iannone, Maria Antonietta D'Agostino, Clodoveo Ferri, Marco Matucci Cerinic, Silvia Laura Bosello, on behalf of SPRING collaborators   +77 more
wiley   +1 more source