Results 81 to 90 of about 36,378 (225)
Mad2, Bub3, and Mps1 regulate chromosome segregation and mitotic synchrony in Giardia intestinalis, a binucleate protist lacking an anaphase-promoting complex. [PDF]
, 2014 The binucleate pathogen Giardia intestinalis is a highly divergent eukaryote with a semiopen mitosis, lacking an anaphase-promoting complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.
Cande, W Zacheus, Vicente, Juan-Jesus
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In Vitro Kinetochore Assembly [PDF]
, 2016 The kinetochore is the primary site of interaction between chromosomes and microtubules of the mitotic spindle during chromosome segregation. Kinetochores are composed of more than 100 proteins that transiently assemble during mitosis at a single epigenetically defined region on each chromosome, known as the centromere.
Aaron F. Straight, Matthew D. D. Miell
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Mosaic origin of the eukaryotic kinetochore [PDF]
Proceedings of the National Academy of Sciences, 2019 SignificanceEukaryotes, which include diverse species like animals, fungi, and plants, have cells that are fundamentally more complex than prokaryotic cells, such as bacteria. However, eukaryotes did evolve from prokaryotes, so they must have acquired this cellular complexity after they diverged from prokaryotes.
Geert J. P. L. Kops +7 more
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Nature Communications, 2016 Ska1 is a kinetochore-localised protein that couples kinetochore movement to microtubule (MT) depolymerisation. Here Thomas et al. show that the MT +TIP binding protein EB1 recruits Ska1 to the MT-kinetochore interface and stabilises the interaction ...
Geethu E. Thomas +12 more
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The roles of kinetochore of micronucleus in mitosis of HeLa cells: a live cell imaging study
Cancer Cell International, 2019 Background Micronuclei (MNi) are extensively used to evaluate genotoxic effects and chromosome instability. However, the roles of kinetochore of MN in mitosis have not been completely addressed.
Erkang Jiang +7 more
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Chromosome segregation in plant meiosis [PDF]
, 2014 Faithful chromosome segregation in meiosis is essential for ploidy stability over sexual life cycles. In plants, defective chromosome segregation caused by gene mutations or other factors leads to the formation of unbalanced or unreduced gametes creating
De Storme, Nico +4 more
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Kinetochore microtubules shorten by loss of subunits at the kinetochores of prometaphase chromosomes [PDF]
Journal of Cell Science, 1991 ABSTRACT The site of tubulin subunit dissociation was determined during poleward chromosome movement in prometaphase newt lung cell mitotic spindles using fluorescence photobleaching techniques and nocodazole-induced spindle shortening.
Lynne Cassimeris, Edward D. Salmon
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PLoS Genetics, 2015 In oocytes, where centrosomes are absent, the chromosomes direct the assembly of a bipolar spindle. Interactions between chromosomes and microtubules are essential for both spindle formation and chromosome segregation, but the nature and function of ...
Sarah J Radford +4 more
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eLife, 2020 The spindle generates force to segregate chromosomes at cell division. In mammalian cells, kinetochore-fibers connect chromosomes to the spindle. The dynamic spindle anchors kinetochore-fibers in space and time to move chromosomes.
Pooja Suresh +2 more
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Chromosome Oscillations in Mitosis
, 2005 Successful cell division requires a tight regulation of chromosome motion via the activity of molecular motors. Many of the key players at the origin of the forces generating the movement have been identified, but their spatial and temporal organization ...
A. P. Joglekar +8 more
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