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The kinetochores of Caenorhabditis elegans
Chromosoma, 1982Light microscopy of the mitotic chromosomes of Caenorhabditis elegans suggests that non-localized kinetochores are present, since the chromosomes appear as stiff rods 1 to 2 micrometers in length and lack any visible constriction. The holokinetic structure was confirmed by reconstructions of electron micrographs of dividing nuclei in serially sectioned
D G, Albertson, J N, Thomson
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Kinetochore structure and function
Trends in Cell Biology, 2005The vertebrate kinetochore is a complex structure that specifies the attachments between the chromosomes and microtubules of the spindle and is thus essential for accurate chromosome segregation. Kinetochores are assembled on centromeric chromatin through complex pathways that are coordinated with the cell cycle.
Gordon K, Chan +2 more
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Structure of the mammalian kinetochore
Chromosoma, 1981The structure of the mammalian trilaminar kinetochore was investigated using stereo electron microscopy of chromosomes in hypotonic solutions which unraveled the chromosome but maintained microtubules. Mouse and Chinese hamster ovary cells were arrested in Colcemid and allowed to reform microtubules after Colcemid was removed. Recovered cells were then
H, Ris, P L, Witt
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The Formation, Structure, and Composition of the Mammalian Kinetochore and Kinetochore Fiber
1982Publisher Summary Advances in the understanding of the formation, structure, and chemistry of the mammalian kinetochore and its associated fiber are summarized in the chapter. The initiation of chromosome movement during cell division can be correlated with the formation of a fiber, composed primarily of microtubules (MTs) and associated proteins ...
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Evolving Centromeres and Kinetochores
2017The genetic material, contained on chromosomes, is often described as the "blueprint for life." During nuclear division, the chromosomes are pulled into each of the two daughter nuclei by the coordination of spindle microtubules, kinetochores, centromeres, and chromatin.
Steven, Friedman, Michael, Freitag
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A blueprint for kinetochores — new insights into the molecular mechanics of cell division
Nature Reviews Molecular Cell Biology, 2011Stefan Westermann +2 more
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