Results 111 to 120 of about 3,159 (153)
Setting a new standard for kinetochores
Journal of Cell Biology, 2011 Two studies reassess the number of proteins at yeast kinetochores and centromeres.
Ben Short
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Unattached kinetochores drive their own capturing by sequestering a CLASP
Nature Communications, 2018 Kinetochores that are not attached to microtubules prevent chromosome missegregation via the spindle assembly checkpoint. We show that they also promote their own capturing. Similar to what governs the localization of spindle assembly checkpoint proteins,
Jennifer Ortiz, Johannes Lechner
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Journal of Cell Science, 2023
ABSTRACT The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as long-range organelle transport in neuronal axons and spindle assembly in dividing cells.
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ABSTRACT The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as long-range organelle transport in neuronal axons and spindle assembly in dividing cells.
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The kinetochore of the hemiptera
Chromosoma, 1961(1) Breakage of chromosomes was induced by X-rays in adult and nymphal males of Euschistus servus, E. tristigmus and Solubea pugnax (Pentatomidae; Hemiptera-Heteroptera). (2) The diffuse nature of the kinetochore is demonstrated by the ability of chromosome fragments to perpetuate themselves mitotically through many cell generations of ...
S, HUGHES-SCHRADER, F, SCHRADER
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Trends in Plant Science, 2000
Kinetochores are large protein complexes that bind to centromeres. By interacting with microtubules and their associated motor proteins, kinetochores both generate and regulate chromosome movement. Kinetochores also function in the spindle checkpoint; a surveillance mechanism that ensures that metaphase is complete before anaphase begins.
Hong-Guo Yu +3 more
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Kinetochores are large protein complexes that bind to centromeres. By interacting with microtubules and their associated motor proteins, kinetochores both generate and regulate chromosome movement. Kinetochores also function in the spindle checkpoint; a surveillance mechanism that ensures that metaphase is complete before anaphase begins.
Hong-Guo Yu +3 more
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CENP-E Function at Kinetochores Is Essential for Chromosome Alignment [PDF]
Journal of Cell Biology, 1997 CENP-E is a kinesin-like protein that binds to kinetochores and may provide functions that are critical for normal chromosome motility during mitosis. To directly test the in vivo function of CENP-E, we microinjected affinity-purified antibodies to block
Gordon K Chan, Paul Maddox, E D Salmon
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Biochemical Society Transactions, 2006
The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby promoting organization of mitotic ...
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The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby promoting organization of mitotic ...
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Centromeres and kinetochores of Brassicaceae
Chromosome Research, 2014The centromere-the primary constriction of monocentric chromosomes-is essential for correct segregation of chromosomes during mitosis and meiosis. Centromeric DNA varies between different organisms in sequence composition and extension. The main components of centromeric and pericentromeric DNA of Brassicaceae species are centromeric satellite repeats.
Inna, Lermontova +2 more
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Centromere and kinetochore structure
Current Biology, 1992Recent studies have begun to yield some insight into the structural and regulatory components of centromeres, and new assays have been developed that promise to be of use in advancing our understanding of centromere structure and function. In the budding yeast Saccharomyces cerevisiae new proteins that are required for centromere function have been ...
W C, Earnshaw, J E, Tomkiel
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The structure of a primitive kinetochore
Trends in Biochemical Sciences, 1989The isolation of yeast centromeres has provided the opportunity to describe the molecular structure of chromosome attachments to the mitotic spindle. Nucleolytic probes of chromatin structure and construction of conditional mutants in centromere function have been used to study the regulation and assembly of centromeres throughout the cell cycle in ...
K, Bloom, A, Hill, M, Kenna, M, Saunders
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