Results 91 to 100 of about 3,159 (153)

Localization of Mad2 to Kinetochores Depends on Microtubule Attachment, Not Tension

, 1998
A single unattached kinetochore can delay anaphase onset in mitotic tissue culture cells (Rieder, C.L., A. Schultz, R. Cole, G. Sluder. 1994. J. Cell Biol. 127:1301–1310).
Jennifer C. Waters, Waters, Jennifer C., Murray, Andrew W., E.D. Salmon, Salmon, E. D., Chen, Rey Huei, Rey-Huei Chen, Andrew W. Murray   +7 more
core   +1 more source

Cell cycle: Checkpoint proteins and kinetochores

, 1997
Vertebrate homologs of yeast spindle assembly checkpoint proteins are localized to kinetochores and may act as a sensor for proper chromosome attachment to the mitotic ...
Straight, Aaron F
core   +1 more source

The dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spindle assembly checkpoint response in Cryptococcus neoformans.

PLoS Genetics
During chromosome segregation, the spindle assembly checkpoint (SAC) detects errors in kinetochore-microtubule attachments. Timely activation and maintenance of the SAC until defects are corrected is essential for genome stability.
Satya Dev Polisetty, Krishna Bhat, Kuladeep Das, Ivan Clark, Kevin G Hardwick, Kaustuv Sanyal   +5 more
doaj   +1 more source

Kinetochores Generate Microtubules with Distal Plus Ends:Their Roles and Limited Lifetime in Mitosis

, 2010
In early mitosis, microtubules can be generated at kinetochores as well as at spindle poles. However, the role and regulation of kinetochore-derived microtubules have been unclear.
Tanaka, Tomoyuki U.; id_orcid, Komoto, Shinya, Tanaka, Kozo, Tanaka, Tomoyuki U., Antony, Claude, Kitamura, Etsushi, Kitamura, Yoko   +6 more
core   +1 more source

The Saccharomyces cerevisiae kinetochore

FEBS Letters, 1996
Accurate chromosome segregation is DApenDAnt on a specialized chromosomal structure, the kinetochore/centromere. The only essential constituent of the S. cerevisiae kinetochore established today is CBF3, a multisubunit complex that binds to S. cerevisiae centromere DNA.
Lechner, Johannes, Ortiz, Jennifer
openaire   +2 more sources

Captivating Capture: How Microtubules Attach to Kinetochores

, 2003
Accurate chromosome segregation is essential to ensure genomic stability because the aneuploidy that results from segregation errors leads to birth defects and contributes to the development of cancer.
Biggins, Sue, Walczak, Claire E
core   +1 more source

Spindle Checkpoint at Kinetochores

, 2016
The kinetochore—a large protein assembly on centromeric chromatin—functions as the docking site for spindle microtubules and as a signaling hub for the spindle checkpoint.
Kim, Soonjoung
core  

How kinetochores CCAN resist force

, 2014
Kinetochores orchestrate chromosome segregation during mitosis and must cope with dynamic forces generated by attached microtubules. In this issue of Developmental Cell, Suzuki et al. (2014) demonstrate that the constitutive centromere-associated network
McAinsh, Andrew D.
core   +1 more source

Chromosome segregation during spermatogenesis occurs through a unique center-kinetic mechanism in holocentric moth species.

PLoS Genetics
Precise regulation of chromosome dynamics in the germline is essential for reproductive success across species. Yet, the mechanisms underlying meiotic chromosomal events such as homolog pairing and chromosome segregation are not fully understood in many ...
Clio Hockens, Hernan Lorenzi, Tricia T Wang, Elissa P Lei, Leah F Rosin   +4 more
doaj   +1 more source

Fission yeast Wee1 is required for stable kinetochore-microtubule attachment

Open Biology
Wee1 is a cell cycle regulator that phosphorylates Cdk1/Cdc2 and inhibits G2/M transition. Loss of Wee1 in fission yeast results in an early onset of mitosis.
Masahiro Takado, Takaharu G. Yamamoto, Yuji Chikashige, Tomohiro Matsumoto   +3 more
doaj   +1 more source