Results 81 to 90 of about 3,159 (153)

Studying Kinetochore Kinases [PDF]

, 2016
Mitotic kinetochores are signaling network hubs that regulate chromosome movements, attachment error-correction, and the spindle assembly checkpoint. Key switches in these networks are kinases and phosphatases that enable rapid responses to changing conditions.
Saurin, Adrian T., Kops, Geert J. P. L.
openaire   +4 more sources

Merotelic kinetochores in mammalian tissue cells

, 2005
Merotelic kinetochore attachment is a major source of aneuploidy in mammalian tissue cells in culture. Mammalian kinetochores typically have binding sites for about 20–25 kinetochore microtubules.
Cimini, D., Salmon, E. D., Cameron, L. A., DeLuca, J. G.   +3 more
core   +1 more source

Chromosome segregation in plant meiosis

Frontiers in Plant Science, 2014
Faithful chromosome segregation in meiosis is essential for ploidy stability over sexual life cycles. In plants, defective chromosome segregation caused by gene mutations or other factors leads to the formation of unbalanced or unreduced gametes creating
Linda eZamariola, Choon Lin eTiang, Nico eDe Storme, Wojtek ePawlowski, Danny eGeelen   +4 more
doaj   +1 more source

Kinetochores: Orchestrating the Chromosomal Minuet

, 2010
SummaryWhen it comes to microtubules, kinetochores leave nothing to chance. Recent studies have provided insight into an amazingly choreographed dance between the proteins in the kinetochore and their substrate and power source — the ...
Stukenberg, P. Todd, Foltz, Daniel R., Daniel R. Foltz, P. Todd Stukenberg   +3 more
core   +1 more source

The structure of purified kinetochores reveals multiple microtubule-attachment sites [PDF]

, 2012
Chromosomes must be accurately partitioned to daughter cells to prevent aneuploidy, a hallmark of many tumors and birth defects. Kinetochores are the macromolecular machines that segregate chromosomes by maintaining load-bearing attachments to the ...
Tamir Gonen, Akiyoshi, Bungo, Nicole Duggan, Shane Gonen, Sue Biggins, Gonen, Shane, Iadanza, Matthew G, Gonen, S, Iadanza, MG, Dan Shi, Gonen, T, Shi, D, Akiyoshi, B, Biggins, S, Duggan, N, Biggins, Sue, Shi, Dan, Bungo Akiyoshi, Duggan, Nicole, Gonen, Tamir, Matthew G Iadanza   +20 more
core   +1 more source

Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates [PDF]

, 2017
Mitotic duration is determined by activation of the anaphase-promoting complex/cyclosome (APC/C) bound to its coactivator, Cdc20. Kinetochores, the microtubule-interacting machines on chromosomes, restrain mitotic exit when not attached to spindle ...
Bram Prevo, Dhanya K. Cheerambathur, Lara-Gonzalez, Pablo, Arshad Desai, Cheerambathur, Dhanya K, Kim, Taekyung, Taekyung Kim, Pablo Lara-Gonzalez, Prevo, Bram, Meitinger, Franz, Franz Meitinger, Karen Oegema, Oegema, Karen, Desai, Arshad   +13 more
core   +1 more source

Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex

Nature Communications
The spindle assembly checkpoint (SAC) ensures mitotic exit occurs only after sister chromatid biorientation, but how this coordination is mechanistically achieved remains unclear.
Suruchi Sethi, Sabrina Ghetti, Verena Cmentowski, Teresa Benedetta Guerriere, Patricia Stege, Valentina Piano, Andrea Musacchio   +6 more
doaj   +1 more source

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

eLife, 2015
The spindle assembly checkpoint (SAC) monitors and promotes kinetochore–microtubule attachment during mitosis. Bub1 and BubR1, SAC components, originated from duplication of an ancestor gene.
Katharina Overlack, Ivana Primorac, Mathijs Vleugel, Veronica Krenn, Stefano Maffini, Ingrid Hoffmann, Geert J P L Kops, Andrea Musacchio   +7 more
doaj   +1 more source

Chromosome congression by CENP-E and CENP-Q dependent pathways [PDF]

The timely and efficient movement of chromosomes to the spindle equator during mitosis is a prerequisite for accurate chromosome segregation.
Bancroft, James M.
core  

Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy [PDF]

, 2019
The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by monitoring kinetochore-microtubule interactions. SAC proteins are shed from kinetochores once stable attachments are achieved.
Van Oudenaarden, Alexander, Sacristan, Carlos, Kuijt, Timo E.F., Etemad, Banafsheh, Kops, Geert J.P.L., Vertesy, Abel   +5 more
core