Results 71 to 80 of about 3,159 (153)

Dynein at kinetochores: Making the connection

, 2017
Dynein removes the checkpoint proteins from kinetochores once chromosomes are bioriented. In this issue, Gama et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610108) and Mosalaganti et al. (2017. J. Cell Biol.
Toni McHugh, Julie P.I. Welburn
core   +1 more source

Pac-man motility of kinetochores unleashed by laser microsurgery [PDF]

, 2012
© The Author(s), 2012. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology of the Cell 23 (2012): 3133-3142, doi:10.1091/mbc.E12-04-0314.We report on ...
LaFountain, James R., Cohan, Christopher S., Oldenbourg, Rudolf   +2 more
core   +1 more source

MPS1 promotes timely spindle bipolarization to prevent kinetochore-microtubule attachment errors in oocytes

The EMBO Journal
Incorrect kinetochore–microtubule attachment leads to chromosome segregation errors. The risk of incorrect attachment is high in acentrosomal oocytes, where kinetochores are surrounded by randomly oriented microtubules until spindle bipolarization ...
Shuhei Yoshida, Reiko Nakagawa, Kohei Asai, Tomoya S Kitajima   +3 more
doaj   +1 more source

Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere

eLife, 2014
To protect against aneuploidy, chromosomes must attach to microtubules from opposite poles (‘biorientation’) prior to their segregation during mitosis.
Kitty F Verzijlbergen, Olga O Nerusheva, David Kelly, Alastair Kerr, Dean Clift, Flavia de Lima Alves, Juri Rappsilber, Adele L Marston   +7 more
doaj   +1 more source

Centromeric Non-Coding RNAs: Conservation and Diversity in Function

Non-Coding RNA, 2020
Chromosome segregation is strictly regulated for the proper distribution of genetic material to daughter cells. During this process, mitotic chromosomes are pulled to both poles by bundles of microtubules attached to kinetochores that are assembled on ...
Takashi Ideue, Tokio Tani
doaj   +1 more source

The dynamic protein architecture of human kinetochores

, 2009
Accurate segregation of genomic DNA during mitosis is one of the cell’s most vital functions. Errors in this process result in defects that are implicated in many human diseases and developmental disorders.
O'Quinn, Ryan Patrick
core   +1 more source

Spindle Checkpoint Protein Dynamics at Kinetochores in Living Cells

, 2004
Background: To test current models for how unattached and untense kinetochores prevent Cdc20 activation of the anaphase-promoting complex/cyclosome (APC/C) throughout the spindle and the cytoplasm, we used GFP fusions and live-cell imaging to quantify ...
Farrar, Emily M, Moree, Ben, Stewart, Scott, Salmon, E.D, Howell, Bonnie, Fang, Guowei, Farrar, Emily, Howell, Bonnie J   +7 more
core   +1 more source

The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores

eLife, 2016
The spindle- and kinetochore-associated (Ska) complex is essential for normal anaphase onset in mitosis. The C-terminal domain (CTD) of Ska1 binds microtubules and was proposed to facilitate kinetochore movement on depolymerizing spindle microtubules ...
Sushama Sivakumar, Paweł Ł Janczyk, Qianhui Qu, Chad A Brautigam, P Todd Stukenberg, Hongtao Yu, Gary J Gorbsky   +6 more
doaj   +1 more source

Meiosis I chromosome segregation is established through regulation of microtubule–kinetochore interactions

eLife, 2012
During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain together.
Matthew P Miller, Elçin Ünal, Gloria A Brar, Angelika Amon   +3 more
doaj   +1 more source

Release of Mps1 from Kinetochores Is Crucial for Timely Anaphase Onset [PDF]

, 2010
Mps1 kinase activity is required for proper chromosome segregation during mitosis through its involvements in microtubule–chromosome attachment error correction and the mitotic checkpoint.
Nicholas P. Kwiatkowski, Tale Sliedrecht, Tobias B. Dansen, Jelluma, Nannette, Sliedrecht, Tale, Dansen, Tobias B., Geert J.P.L. Kops, Kwiatkowski, Nicholas, Nannette Jelluma, Kops, Geert J.P.L.   +9 more
core   +1 more source