Results 51 to 60 of about 3,159 (153)
Fin1-PP1 Helps Clear Spindle Assembly Checkpoint Protein Bub1 from Kinetochores in Anaphase
Cell Reports, 2016 Summary: The spindle assembly checkpoint (SAC) monitors chromosome attachment defects, and the assembly of SAC proteins at kinetochores is essential for its activation, but the SAC disassembly process remains unknown.
Michael Bokros +4 more
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Kinetochore structure: electron spectroscopic imaging of the kinetochore. [PDF]
The Journal of cell biology, 1989 The structure of the kinetochore in thin section has been studied in the Indian muntjac by an electron spectroscopic imaging technique. This procedures allows the analysis of the distribution of phosphorus within the layers of the kinetochore. The results indicate that this element is a major component of both the inner and outer plates whereas it is ...
J B, Rattner, D P, Bazett-Jones
openaire +2 more sources
Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint. [PDF]
PLoS Genetics, 2012 The attachment of sister kinetochores by microtubules emanating from opposite spindle poles establishes chromosome bipolar attachment, which generates tension on chromosomes and is essential for sister-chromatid segregation.
Fengzhi Jin +4 more
doaj +1 more source
A Perikinetochoric Ring Defined by MCAK and Aurora-B as a Novel Centromere Domain. [PDF]
PLoS Genetics, 2006 Mitotic Centromere-Associated Kinesin (MCAK) is a member of the kinesin-13 subfamily of kinesin-related proteins. In mitosis, this microtubule-depolymerising kinesin seems to be implicated in chromosome segregation and in the correction of improper ...
María Teresa Parra +7 more
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Stochastic modelling of chromosomal segregation : errors can introduce correction
, 2014 Cell division is a complex process requiring the cell to have many internal checks so that division may proceed and be completed correctly. Failure to divide correctly can have serious consequences, including progression to cancer.
Roitershtein, Alexander +5 more
core +1 more source
How do Kinetochores CLASP Dynamic Microtubules? [PDF]
, 2003 Maintenance of genetic stability during cell division requires binding of chromosomes to the mitotic spindle, a process that involves attachment of spindle microtubules to kinetochores.
William C. Earnshaw +9 more
core +1 more source
A Molecular View of Kinetochore Assembly and Function
Biology, 2017 Kinetochores are large protein assemblies that connect chromosomes to microtubules of the mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to its daughters.
Andrea Musacchio, Arshad Desai
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Reductionism at the vertebrate kinetochore [PDF]
Journal of Cell Biology, 2012 The kinetochore forms the site of attachment for mitotic spindle microtubules driving chromosome segregation. The interdependent protein interactions in this large structure have made it difficult to dissect the function of its components. In this issue, Hori et al. (2013. J. Cell Biol.
Stankovic, Ana, Jansen, Lars E.T.
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, 2011 Researchers detail how kinetochores respond to force from spindle.
Mitch Leslie
core +1 more source
Mechanisms to Avoid and Correct Erroneous Kinetochore-Microtubule Attachments
Biology, 2017 In dividing vertebrate cells multiple microtubules must connect to mitotic kinetochores in a highly stereotypical manner, with each sister kinetochore forming microtubule attachments to only one spindle pole.
Michael A. Lampson +1 more
doaj +1 more source