Results 31 to 40 of about 3,159 (153)

Visualizing kinetochore architecture [PDF]

Current Opinion in Structural Biology, 2011
Kinetochores are large macromolecular assemblies that link chromosomes to spindle microtubules (MTs) during mitosis. Here we review recent advances in the study of core MT-binding kinetochore complexes using electron microcopy methods in vitro and nanometer-accuracy fluorescence microscopy in vivo.
Gregory, Alushin, Eva, Nogales
openaire   +2 more sources

Phosphatase-regulated recruitment of the spindle- and kinetochore-associated (Ska) complex to kinetochores

Biology Open, 2017
Kinetochores move chromosomes on dynamic spindle microtubules and regulate signaling of the spindle checkpoint. The spindle- and kinetochore-associated (Ska) complex, a hexamer composed of two copies of Ska1, Ska2 and Ska3, has been implicated in both ...
Sushama Sivakumar, Gary J. Gorbsky
doaj   +1 more source

Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors

Cell Reports, 2020
Summary: Kinetochores are multi-protein machines that form dynamic attachments to microtubules and control chromosome segregation. High fidelity is ensured because kinetochores can monitor attachment status and tension, using this information to activate
Emanuele Roscioli, Tsvetelina E. Germanova, Christopher A. Smith, Peter A. Embacher, Muriel Erent, Amelia I. Thompson, Nigel J. Burroughs, Andrew D. McAinsh   +7 more
doaj   +1 more source

Integrating Functions at the Kinetochore [PDF]

Cell, 2002
Kinetochore components have catalytic as well as structural activities. New evidence illustrates how these proteins integrate spindle morphogenesis with regulation of the timing and accuracy of chromosome segregation.
Shimoda, Soni L., Solomon, Frank
openaire   +2 more sources

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis [PDF]

, 2007
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors.
Newton, Ian P., Clarke, Alan Richard, Jamieson, TJ, Sansom, Owen, Nathke, Inke S.; id_orcid, Alan Clarke, Newton, IP, Clarke, A, Ian P. Newton, Owen Sansom, Thomas J. Jamieson, Dikovskaya, D, Meniel, V, Kroboth, K, Sansom, O, Dikovskaya, Dina, Oakley, A, Oakley, Abigail, Abigail Oakley, Nathke, IS, Schiffmann, D, Valerie Meniel, Clarke, Alan, Schiffmann, David, Kroboth, Karin, David Schiffmann, Nathke, Inke S., Sansom, Owen J., Dina Dikovskaya, Inke S. Näthke, Karin Kroboth, Meniel, Valerie, Jamieson, Thomas J.   +32 more
core   +1 more source

An assay for de novo kinetochore assembly reveals a key role for the CENP-T pathway in budding yeast

eLife, 2018
Chromosome segregation depends on the kinetochore, the machine that establishes force-bearing attachments between DNA and spindle microtubules. Kinetochores are formed every cell cycle via a highly regulated process that requires coordinated assembly of ...
Jackie Lang, Adrienne Barber, Sue Biggins   +2 more
doaj   +1 more source

Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing

Cell Reports, 2019
Summary: Faithful chromosome segregation relies on the ability of the spindle assembly checkpoint (SAC) to delay anaphase onset until chromosomes are attached to the mitotic spindle via their kinetochores.
Spyridon T. Pachis, Yoshitaka Hiruma, Eelco C. Tromer, Anastassis Perrakis, Geert J.P.L. Kops   +4 more
doaj   +1 more source

Establishment of the vertebrate kinetochores [PDF]

Chromosome Research, 2012
The centromere is essential for accurate chromosome segregation during mitosis and meiosis to achieve transmission of genetic information to daughter cells. To facilitate accurate chromosome segregation, the centromere serves several specific functions, including microtubule binding, spindle-checkpoint control, and sister chromatid cohesion.
Tetsuya, Hori, Tatsuo, Fukagawa
openaire   +2 more sources

The Art of Chromosome Capture: Kinetochore Structures Across Evolution. [PDF]

Structural Dynamics
Kinetochores are essential macromolecular machines that anchor chromosomes to the mitotic spindle, ensuring accurate chromosome segregation during cell division.
Stanislau Yatskevich
doaj   +1 more source

A TOGgle for Tension at Kinetochores [PDF]

Cell, 2016
Differential stability of kinetochore-microtubule attachments at low versus high tension is critical for accurate chromosome segregation. Miller et al. find that a TOG domain microtubule-binding protein imparts intrinsic tension selectivity to kinetochore-microtubule attachments.
Dhanya K, Cheerambathur, Bram, Prevo, Arshad, Desai   +2 more
openaire   +2 more sources