Results 41 to 50 of about 3,159 (153)
Regulation of chromosome congression : focus on the function of hSpindly and the kinetochore recruitment of the Ska complex [PDF]
, 2011 Mitosis is a process in which cells divide their genetic materials equally into two daughter cells. During mitosis, specialized structures called kinetochores (KTs), located at the centromeric regions of chromosomes, are captured by microtubules (MTs ...
Chan, Ying Wai
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Balancing the kinetochore ledger [PDF]
Journal of Cell Biology, 2012 Reduction of polo-like kinase-1 (Plk1) at kinetochores as cells progress from prometaphase to metaphase is surprising given that the kinase is thought to stabilize kinetochore–microtubule (kt–MT) attachments. In this issue, Liu et al. (2012. J. Cell Biol.
Cane, Stuart, Maresca, Thomas J.
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Characterization of mitotic checkpoint complexes [PDF]
, 2011 In eukaryotes, chromosome segregation critically depends on the establishment of productive contacts between kinetochores (KTs), specialized chromosomal structures, and the spindle microtubules (MTs).
Fava, Luca
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eLife, 2015 The congression of chromosomes to the spindle equator involves the directed motility of bi-orientated sister kinetochores. Sister kinetochores bind bundles of dynamic microtubules and are physically connected through centromeric chromatin.
Nigel J Burroughs +2 more
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Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation
Cell Reports, 2021 Summary: Stable transmission of genetic material during cell division requires accurate chromosome segregation. PLK1 dynamics at kinetochores control establishment of correct kinetochore-microtubule attachments and subsequent silencing of the spindle ...
Leilei Xu +21 more
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The path of DNA in the kinetochore [PDF]
Current Biology, 2006 The kinetochore is the protein-DNA complex at eukaryotic centromeres that functions as the attachment site for spindle microtubules. In budding yeast, the centromere spans 120 bp, there is a single microtubule per kinetochore, and the entire spindle is composed of 16 kinetochore microtubules plus four interpolar microtubules from each pole.
Bloom, Kerry +2 more
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A satellite explosion in the genome of holocentric nematodes. [PDF]
PLoS ONE, 2013 Centromere sequences in the genome are associated with the formation of kinetochores, where spindle microtubules grow in mitosis. Centromere sequences usually have long tandem repeats (satellites).
Juan A Subirana, Xavier Messeguer
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Tension Management in the Kinetochore [PDF]
Current Biology, 2010 The kinetochore is the protein machine built at the centromere that integrates mechanical force and chemical energy from dynamic microtubules into directed chromosome motion. The kinetochore also provides a powerful signaling function that is able to alter the properties of the spindle checkpoint and initiate a signal transduction cascade that leads to
Bloom, Kerry, Yeh, Elaine
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Kinetochore-microtubule error correction is driven by differentially regulated interaction modes
, 2015 For proper chromosome segregation, sister kinetochores must interact with microtubules from opposite spindle poles (bi-orientation). To establish bi-orientation, aberrant kinetochore-microtubule attachments are disrupted (error correction) by aurora B ...
Zhang, T +13 more
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De novo assembly and single-molecule study of kinetochore-microtubule interactions
Frontiers in Cell and Developmental BiologyKinetochores are essential molecular machines composed of dozens of protein subcomplexes that assemble onto specialized centromeric nucleosomes during every cell cycle prior to mitosis.
Joshua D. Larson +4 more
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