Results 61 to 70 of about 3,159 (153)
Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2
Nature Communications, 2016 The spindle assembly checkpoint relies on the accumulation of Mad1-Mad2 at kinetochores, but the mechanism of regulation is not known. Here Zhou et al.
Haining Zhou +4 more
doaj +1 more source
A Nucleoporin at the Meiotic Kinetochore [PDF]
Developmental Cell, 2016 In this issue of Developmental Cell, Hattersley et al. (2016) use the unique biology of meiosis I, in which the cell can exit the division without reforming the nuclear envelope, to uncover an intriguing role of the nucleoporin MEL-28 in mediating chromosome segregation via its interaction with PP1 at the kinetochore.
Amanda M, Bonner, R Scott, Hawley
openaire +2 more sources
Dissecting mitosis by RNAi in Drosophila tissue culture cells
Biological Procedures Online, 2003 Here we describe a detailed methodology to study the function of genes whose products function during mitosis by dsRNA-mediated interference (RNAi) in cultured cells of Drosophila melanogaster.
Maiato Helder +2 more
doaj +1 more source
In Vitro Kinetochore Assembly [PDF]
, 2016 The kinetochore is the primary site of interaction between chromosomes and microtubules of the mitotic spindle during chromosome segregation. Kinetochores are composed of more than 100 proteins that transiently assemble during mitosis at a single epigenetically defined region on each chromosome, known as the centromere.
Matthew D D, Miell, Aaron F, Straight
openaire +2 more sources
MAD1: Kinetochore Receptors and Catalytic Mechanisms
Frontiers in Cell and Developmental Biology, 2018 The mitotic checkpoint monitors kinetochore-microtubule attachment, delays anaphase onset and prevents aneuploidy when unattached or tensionless kinetochores are present in cells.
Yibo Luo, Ejaz Ahmad, Song-Tao Liu
doaj +1 more source
Cell Division: Kinetochores SKAdaddle
, 2013 SummaryAccurate chromosome segregation during cell division requires that kinetochores couple microtubule dynamics to chromosome movement. New research reveals that the kinetochore-associated Ska1 complex hangs on to depolymerizing microtubules and ...
Ye, Anna A., Maresca, Thomas J.
core +1 more source
Life Science AllianceUnlike ensemble averaging methods, this study visualizes the single molecules of Ipl1 in live yeast cells to quantify its recruitment dynamics and assembly as a part of the CPC at the kinetochores. Aurora kinase B, Ipl1 in Saccharomyces cerevisiae , is a
Nitesh Kumar Podh +8 more
doaj +1 more source
Nature Communications, 2019 How the chromosome passenger complex (CPC) phosphorylates the kinetochores that can be a micron away to control mitotic events is unknown. Here the authors find that the CPC directly binds microtubules near inner centromeres, which controls its ability ...
Prasad Trivedi +5 more
doaj +1 more source
Dynamics and control of sister kinetochore behavior during the meiotic divisions in Drosophila spermatocytes. [PDF]
PLoS Genetics, 2018 Sister kinetochores are connected to the same spindle pole during meiosis I and to opposite poles during meiosis II. The molecular mechanisms controlling the distinct behavior of sister kinetochores during the two meiotic divisions are poorly understood.
Soumya Chaurasia, Christian F Lehner
doaj +1 more source
Poleward force at the kinetochore in metaphase depends on the number of kinetochore microtubules. [PDF]
The Journal of cell biology, 1990 To examine the dependence of poleward force at a kinetochore on the number of kinetochore microtubules (kMTs), we altered the normal balance in the number of microtubules at opposing homologous kinetochores in meiosis I grasshopper spermatocytes at metaphase with a focused laser microbeam.
T S, Hays, E D, Salmon
openaire +2 more sources