Results 101 to 110 of about 3,159 (153)

Oscillating mitotic newt lung cell kinetochores are, on average, under tension and rarely push

, 1996
Experimentally introduced tension on kinetochores and their centromeres has been shown to stabilize kinetochore attachment to microtubules, modify kinetochore directional instability, and regulate cell-cycle progression into anaphase.

core   +1 more source

Visualization of Mad2 Dynamics at Kinetochores, along Spindle Fibers, and at Spindle Poles in Living Cells

, 2000
The spindle checkpoint prevents errors in chromosome segregation by inhibiting anaphase onset until all chromosomes have aligned at the spindle equator through attachment of their sister kinetochores to microtubules from opposite spindle poles.
G. Fang, A.W. Murray, Howell, B. J., E.D. Salmon, Hoffman, D. B., Salmon, E. D., D.B. Hoffman, B.J. Howell, Fang, G., Murray, A. W.   +9 more
core   +1 more source

Visualization of kinetochores in mammalian meiotic preparations and observations of argentophilic differences between mitotic and meiotic kinetochores

, 1989
Brief staining with AgNO3 was found to differentially stain the kinetochores of chromosomes from diakinesis – metaphase I and metaphase II nuclei of mammals.
Ira F. Greenbaum, Philip D. Sudman
core   +1 more source

Kinetochores [PDF]

Current Biology, 2000
openaire   +2 more sources

Functional characterization of the Csm1-like protein TITAN 9 in Arabidopsis thaliana

iScience
Summary: Kinetochores are essential for chromosome segregation in eukaryotes. An important component of kinetochores in opisthokonta is Csm1. However, its function appears to be diversified and, while Csm1 in budding yeast is a component of the monopolin
Zhijian Zhang, Franziska Böwer, Shinichiro Komaki, Aladár Pettkó-Szandtner, Anastasiia O. Skuba, Eelco C. Tromer, Zoltán Magyar, Maren Heese, Arp Schnittger   +8 more
doaj   +1 more source

The closed form of Mad2 is bound to Mad1 and Cdc20 at unattached kinetochores

, 2018
The spindle assembly checkpoint (SAC) ensures accurate chromosome segregation by delaying anaphase onset in response to unattached kinetochores. Anaphase is delayed by the generation of the mitotic checkpoint complex (MCC) composed of the checkpoint ...
Gang Zhang, Jakob Nilsson
core   +1 more source

Deformations within moving kinetochores reveal different sites of active and passive force generation

, 2012
Kinetochores mediate chromosome segregation at mitosis. They are thought to contain both active, force-producing and passive, frictional interfaces with microtubules whose relative locations have been unclear.
Dumont, S., Salmon, ED, E. D. Salmon, Salmon, E. D., Sophie Dumont, Dumont, Sophie, Timothy J. Mitchison, Mitchison, Timothy J, Mitchison, T. J.   +8 more
core   +1 more source

Organisation of kinetochores in human oocytes [PDF]

A large proportion of human pregnancies have the wrong number of chromosomes, known as aneuploidy, with the chances of having an affected pregnancy increasing with maternal age.
Patel, Jessica
core  

Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast

Thesis (Ph.D.)--University of Washington, 2024In order to propagate, cells must be able to duplicate and faithfully segregate their genetic information.
Barrero, Daniel
core  

Spindle assembly checkpoint activation and silencing at kinetochores [PDF]

Seminars in Cell and Developmental Biology, 2021
The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of kinetochores, the proteinaceous structures that assemble onto chromosomes in mitosis
Pablo LARA-GONZÁLEZ, Jonathon Pines, Arshad Desai   +2 more
exaly   +2 more sources