The FASEB Journal, 2011 The Kir4.1 channel is expressed in the brainstem, retina and kidney. Its heteromerization with Kir5.1 leads to K + currents with distinct properties such as single‐channel conductance, rectification, pH sensitivity and phosphorylation modulations.
Xin Jin +4 more
openaire +1 more source
Unidirectional photoreceptor-to-Müller glia coupling and unique K+ channel expression in Caiman retina. [PDF]
PLoS ONE, 2014 Müller cells, the principal glial cells of the vertebrate retina, are fundamental for the maintenance and function of neuronal cells. In most vertebrates, including humans, Müller cells abundantly express Kir4.1 inwardly rectifying potassium channels ...
Astrid Zayas-Santiago +17 more
doaj +1 more source
Dialogue Between the Clock Gene Bmal1 and Retinopathy: What Is the Exact Relationship? [PDF]
CNS Neurosci TherCircadian rhythm is offering novel insights into the pathogenesis of retinopathy. Bmal1, a key transcriptional regulator of the circadian clock, serves as a critical pathologic cofactor in retinal degeneration. Deficiency in Bmal1 contributes to a broad spectrum of retinal pathological alterations, and modulating the clock gene Bmal1 could potentially ...
Cui Y +7 more
europepmc +2 more sources
Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage. [PDF]
GliaMain Points NBCe1 is upregulated in reactive astrocytes following ischemic stroke. Deletion of astrocytic Nboe1 reduces stroke volume, preserves AQP4 polarization, reduces BBB permeability, and improves neurological function after ischemic stroke. ABSTRACT The electrogenic sodium bicarbonate transporter 1 (NBCe1/Slc4a4), predominantly expressed in ...
Capuk O +16 more
europepmc +2 more sources
Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]
, 2012 Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
A Lux +68 more
core +2 more sources
KIR4.1: K+ channel Illusion or Reality in the autoimmune pathogenesis of multiple sclerosis
Frontiers in Molecular Neuroscience, 2016 Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Many believe autoimmune pathogenesis plays a key role in MS, but its target(s) remains elusive.
Chen Gu
doaj +1 more source
Inwardly rectifying potassium channel 5.1: Structure, function, and possible roles in diseases
Genes and Diseases, 2021 Inwardly rectifying potassium (Kir) channels make it easier for K+ to enter into a cell and subsequently regulate cellular biological functions. Kir5.1 (encoded by KCNJ16) alone can form a homotetramer and can form heterotetramers with Kir4.1 (encoded by
Junhui Zhang +10 more
doaj +1 more source
Kir4.1 Potassium Channel Subunit Is Crucial for Oligodendrocyte Development and In Vivo Myelination [PDF]
, 2001 To understand the cellular and in vivo functions of specific K^+ channels in glia, we have studied mice with a null mutation in the weakly inwardly rectifying K^+ channel subunit Kir4.1.
Jacobs, Russell E. +4 more
core +1 more source
Antiepileptic Drugs Elevate Astrocytic Kir4.1 Expression in the Rat Limbic Region
Frontiers in Pharmacology, 2018 Inwardly rectifying potassium (Kir) channel subunits Kir4.1 are specifically expressed in astrocytes and regulate neuronal excitability by mediating spatial potassium buffering.
Takahiro Mukai +12 more
doaj +1 more source
Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. [PDF]
, 2015 BACKGROUND: Voltage-sensitive dye (VSD) imaging and intrinsic optical signals (IOS) are widely used methods for monitoring spatiotemporal neural activity in extensive networks.
Dobolyi, Arpád +3 more
core +1 more source