Astrocyte Kir4.1 Channels Contribute to Central Respiratory Drive
The FASEB Journal, 2015 Virginia Hawkins, Daniel Mulkey
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Impaired CO2 sensitivity of astrocytes in a mouse model of Rett syndrome [PDF]
, 2015 Rett syndrome is a prototypical neurological disorder characterised by abnormal breathing pattern and reduced ventilatory CO2 sensitivity. Medullary astrocytes are a crucial component of central CO2 /pH chemosensitivity.
Abdala, AP +3 more
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Potassium channel Kir4.1 macromolecular complex in retinal glial cells
Glia, 2005 AbstractA major role for Müller cells in the retina is to buffer changes in the extracellular K+ concentration ([K+]o) resulting from light‐evoked neuronal activity. The primary K+ conductance in Müller cells is the inwardly rectifying K+ channel Kir4.1.
Nathan C, Connors, Paulo, Kofuji
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Frontiers in Genetics, 2019 Inwardly rectifying K+ channel 4.1 (Kir4.1), encoded by KCNJ10, is a member of the inwardly rectifying potassium channel family. In the brain, Kir4.1 is predominant in astrocytic glia and accounts for the spatial buffering of K+ released by neurons ...
Hongfeng Zhang +14 more
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Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow. [PDF]
, 2017 The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately ...
Igarashi, Hironaka +3 more
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EAST/SeSAME Syndrome and Beyond: The Spectrum of Kir4.1- and Kir5.1-Associated Channelopathies
Frontiers in Physiology, 2022 In 2009, two groups independently linked human mutations in the inwardly rectifying K+ channel Kir4.1 (gene name KCNJ10) to a syndrome affecting the central nervous system (CNS), hearing, and renal tubular salt reabsorption.
Jacky Lo +4 more
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Morphological plasticity of astroglia: Understanding synaptic microenvironment [PDF]
, 2015 Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate ...
Heller, JP, Rusakov, DA
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The FASEB Journal, 2012 Mutations in Kir4.1 cause renal salt and Mg wasting (EAST/ SeSAME syndrome, E/S) within the DCT. We have recently found that WT Kir4.1 co‐assembles and co‐localizes with Kir2.3 to produce heteromeric channels with properties similar to native channels in distal nephron. We previously reported that E/S Kir4.1 mutants disrupt Kir2.3 function, raising the
Bernardo Ortega +4 more
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Aquaporin-4 independent Kir4.1 K+ channel function in brain glial cells [PDF]
Molecular and Cellular Neuroscience, 2008 Functional interaction of glial water channel aquaporin-4 (AQP4) and inwardly rectifying K+ channel Kir4.1 has been suggested from their apparent colocalization and biochemical interaction, and from the slowed glial cell K+ uptake in AQP4-deficient brain.
Hua, Zhang, A S, Verkman
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Astroglial Kir4.1 and AQP4 Channels: Key Regulators of Potassium Homeostasis and Their Implications in Autism Spectrum Disorders. [PDF]
Cell Mol NeurobiolAstroglial Kir4.1 and AQP4 channels are pivotal regulators of potassium (K+) and water homeostasis in the brain, playing essential roles in maintaining neuronal stability, facilitating synaptic transmission, and supporting overall brain function.
Abbasian V +4 more
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