Results 181 to 190 of about 5,030 (211)
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The E23K polymorphism in Kir6.2 gene and coronary heart disease
Clinica Chimica Acta, 2006The G to A mutation in the Kir 6.2, the ATP-sensitive potassium channel subunit, resulted a glutamate (E) to lysine (K) substitution at codon 23, and the A allele was shown to have a relationship with high risk to type 2 diabetes in previous study. Their role in coronary heart disease (CHD) has not been evaluated.
Chenling, Xiong +5 more
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Identification of Mutations in the Kir6.2 Subunit of the KATP Channel
2008The beta-cell ATP-sensitive potassium channel is a key component of stimulus -secretion coupling in the pancreatic beta-cell. The channel consists of four subunits of the inwardly rectifying potassium channel Kir6.2 and four subunits of the sulfonylurea receptor 1. Loss of function mutations in the KCNJ11 and ABCC8 genes that encode for Kir6.2 and SUR1
Sarah E, Flanagan, Sian, Ellard
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Identification of molecular regions responsible for the membrane trafficking of Kir6.2
Pflügers Archiv - European Journal of Physiology, 2000The subunits of the pancreatic ATP-sensitive potassium channel Kir6.2 and the sulphonylurea receptor (SUR1) contain endoplasmic reticulum (ER) retention signals (RKR), which prevent their plasma membrane expression when expressed individually. When co-expressed, however, these signals are masked and the complex traffics to the plasma membrane.
E, Hough, D J, Beech, A, Sivaprasadarao
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The Antiarrhythmic Agent Cibenzoline Inhibits KATPChannels by Binding to Kir6.2
Biochemical and Biophysical Research Communications, 1998We reported previously that cibenzoline, an antiarrhythmic agent, inhibits the ATP-sensitive K+ (KATP) channels of pancreatic beta-cells through a binding site distinct from that for glibenclamide. In the present study, we have determined the locus of the action of cibenzoline on KATP channels reconstituted with mutant Kir6.2 and SUR1. We expressed a C-
E, Mukai +5 more
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Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006Epoxyeicosatrienoic acids (EETs), the cytochrome P450 metabolites of arachidonic acid (AA), are potent and stereospecific activators of cardiac ATP-sensitive K(+)(K(ATP)) channels. EETs activate K(ATP) channels by reducing channel sensitivity to ATP. In this study, we determined the direct effects of EETs on the binding of ATP to K(ATP) channel protein.
Xiao-Li, Wang +4 more
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Enhanced MK-801-induced locomotion in Kir6.2 knockout mice
Neuroscience Research, 2012ATP-sensitive K(+) (K-ATP) channels provide a unique link between cellular energetics and electrical excitability, and also act as a unifying molecular coordinator of the body's response to stress. Although the body's response to stress is implicated in the worsening or relapse of psychotic symptoms in schizophrenia, the role of K-ATP channels remains ...
Yan, Zhou +5 more
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Study of Kir6.2/KCNJ11 gene in a sudden cardiac death pedigree
Molecular Biology Reports, 2007In clinic, the patients with acute myocardial infarction (AMI) are at high risk to develop ischemia-induced ventricular arrhythmias leading to sudden cardiac death (SCD). Some studies suggest that individual susceptibility to ischemia-induced arrhythmia may be related to the genes encoding ion channels.
Jun, Wan +5 more
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Localization of the ATP-sensitive K+ channel subunit Kir6.2 in mouse pancreas
Diabetes, 1997Kir6.2, a member of the inward rectifier K+ channel family, is a component of the ATP-sensitive K+ (KATP) channel considered to play a key role in glucose-induced insulin secretion. We studied the distribution of Kir6.2 in mouse pancreas at the cellular level.
M, Suzuki +4 more
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Kir6.1 improves cardiac dysfunction in diabetic cardiomyopathy via the AKT‐FoxO1 signalling pathway
Journal of Cellular and Molecular Medicine, 2021Jin Xin Wang
exaly